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Article

Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma

  • Authors:
    • Laura Gleason
    • Ladan Afifi
    • Lauren Banner
    • Sahithi Talasila
    • Daniel Joffe
    • Safiyyah Bhatti
    • Onder Alpdogan
    • Pierluigi Porcu
    • Neda Nikbakht
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA, Department of Dermatology, University of California Los Angeles, Los Angeles, CA 90067, USA, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
  • Article Number: 35
    |
    Published online on: March 19, 2024
       https://doi.org/10.3892/mco.2024.2733
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Abstract

Anaplastic large cell lymphoma (ALCL) is a CD30+ peripheral T‑cell lymphoma with a clinical spectrum including cutaneous and systemic presentations. While primary cutaneous ALCL (pcALCL) has a favorable prognosis, systemic ALCL (sALCL) has poorer survival outcomes. Expression of anaplastic lymphoma kinase (ALK) by malignant cells has been suggested to distinguish sALCL from pcALCL. However, there have been documented cases of ALK‑positive ALCL confined to the skin. The present study reviewed characteristics of published cutaneous ALK‑positive ALCL cases to distinguish between these two entities. In 23 identified adults with ALK‑positive pcALCL, 26% developed systemic involvement and 74% had skin‑limited disease. In 14 pediatric patients, 36% had both cutaneous and systemic involvement and 64% had cutaneous disease only. This analysis revealed that pcALCL and sALCL could not reliably be distinguished by ALK expression or nuclear vs. cytoplasmic localization. Localized treatment with frequent monitoring may be sufficient in ALK‑positive pcALCL until there is evidence of progression. Physicians should be aware of the overall spectrum of ALCL, including cutaneous limited disease, systemic disease, disease with NPM‑ALK translocation, disease with ALK positivity and disease with skin recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Gleason L, Afifi L, Banner L, Talasila S, Joffe D, Bhatti S, Alpdogan O, Porcu P and Nikbakht N: Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma. Mol Clin Oncol 20: 35, 2024.
APA
Gleason, L., Afifi, L., Banner, L., Talasila, S., Joffe, D., Bhatti, S. ... Nikbakht, N. (2024). Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma. Molecular and Clinical Oncology, 20, 35. https://doi.org/10.3892/mco.2024.2733
MLA
Gleason, L., Afifi, L., Banner, L., Talasila, S., Joffe, D., Bhatti, S., Alpdogan, O., Porcu, P., Nikbakht, N."Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma". Molecular and Clinical Oncology 20.5 (2024): 35.
Chicago
Gleason, L., Afifi, L., Banner, L., Talasila, S., Joffe, D., Bhatti, S., Alpdogan, O., Porcu, P., Nikbakht, N."Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma". Molecular and Clinical Oncology 20, no. 5 (2024): 35. https://doi.org/10.3892/mco.2024.2733
Copy and paste a formatted citation
x
Spandidos Publications style
Gleason L, Afifi L, Banner L, Talasila S, Joffe D, Bhatti S, Alpdogan O, Porcu P and Nikbakht N: Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma. Mol Clin Oncol 20: 35, 2024.
APA
Gleason, L., Afifi, L., Banner, L., Talasila, S., Joffe, D., Bhatti, S. ... Nikbakht, N. (2024). Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma. Molecular and Clinical Oncology, 20, 35. https://doi.org/10.3892/mco.2024.2733
MLA
Gleason, L., Afifi, L., Banner, L., Talasila, S., Joffe, D., Bhatti, S., Alpdogan, O., Porcu, P., Nikbakht, N."Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma". Molecular and Clinical Oncology 20.5 (2024): 35.
Chicago
Gleason, L., Afifi, L., Banner, L., Talasila, S., Joffe, D., Bhatti, S., Alpdogan, O., Porcu, P., Nikbakht, N."Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma". Molecular and Clinical Oncology 20, no. 5 (2024): 35. https://doi.org/10.3892/mco.2024.2733
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