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Case Report Open Access

Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report

  • Authors:
    • Nao Hoshiba
    • Kayo Kayahashi
    • Sakura Hayashi
    • Satoshi Nomura
    • Midori Nakayama
    • Takashi Iizuka
    • Hiroshi Fujiwara
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan
    Copyright: © Hoshiba et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
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    Published online on: May 28, 2024
       https://doi.org/10.3892/mco.2024.2748
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Abstract

Although adenomyosis is a benign uterine disease, it can turn malignant in rare instances. Cystic adenomyosis is a rare variation of adenomyosis, arising from which 8 cases of clear cell carcinoma have been reported. However, to the best of our knowledge, there have been no previous reports describing the mechanism by which clear cell carcinoma develops from cystic adenomyosis. The present report documents a case of a 73‑year‑old woman who was referred to Kanazawa University Hospital (Kanazawa, Japan) because of cystic adenomyosis, with a solid part inside the cyst. The patient was diagnosed with cystic adenomyosis at Shonan Obstetrics and Gynecology Hospital (Hakusan, Japan) 17 years prior; however, the size of the cyst increased after menopause. Therefore, malignant transformation was suspected, which warranted simple abdominal hysterectomy and bilateral salpingo‑oophorectomy. The final diagnosis of the present case was uterine corpus cancer, clear cell carcinoma, stage IA. Immunohistochemical staining revealed that the normal and transitional atypical epithelial cells lining the cyst wall, in addition to the clear cell carcinoma cells (which were inside mural nodules located on the cyst wall), were positive for 8‑hydroxy‑20‑deoxyguanosine. This observation suggested the presence of chronic oxidative stress around the cystic adenomyosis. Therefore, the present case suggests the possible involvement of chronic oxidative stress in the malignant transformation of cystic adenomyosis to clear cell carcinoma. This mechanism of malignant transformation of cystic adenomyosis appears to be similar to that of the malignant transformation of endometriotic cysts. Therefore, if the size of the cystic adenomyosis increases after menopause or if the solid part appears in the cyst in future cases, then the possibility of malignant transformation should be considered.
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Copy and paste a formatted citation
Spandidos Publications style
Hoshiba N, Kayahashi K, Hayashi S, Nomura S, Nakayama M, Iizuka T and Fujiwara H: Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report. Mol Clin Oncol 21: 50, 2024.
APA
Hoshiba, N., Kayahashi, K., Hayashi, S., Nomura, S., Nakayama, M., Iizuka, T., & Fujiwara, H. (2024). Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report. Molecular and Clinical Oncology, 21, 50. https://doi.org/10.3892/mco.2024.2748
MLA
Hoshiba, N., Kayahashi, K., Hayashi, S., Nomura, S., Nakayama, M., Iizuka, T., Fujiwara, H."Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report". Molecular and Clinical Oncology 21.1 (2024): 50.
Chicago
Hoshiba, N., Kayahashi, K., Hayashi, S., Nomura, S., Nakayama, M., Iizuka, T., Fujiwara, H."Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report". Molecular and Clinical Oncology 21, no. 1 (2024): 50. https://doi.org/10.3892/mco.2024.2748
Copy and paste a formatted citation
x
Spandidos Publications style
Hoshiba N, Kayahashi K, Hayashi S, Nomura S, Nakayama M, Iizuka T and Fujiwara H: Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report. Mol Clin Oncol 21: 50, 2024.
APA
Hoshiba, N., Kayahashi, K., Hayashi, S., Nomura, S., Nakayama, M., Iizuka, T., & Fujiwara, H. (2024). Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report. Molecular and Clinical Oncology, 21, 50. https://doi.org/10.3892/mco.2024.2748
MLA
Hoshiba, N., Kayahashi, K., Hayashi, S., Nomura, S., Nakayama, M., Iizuka, T., Fujiwara, H."Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report". Molecular and Clinical Oncology 21.1 (2024): 50.
Chicago
Hoshiba, N., Kayahashi, K., Hayashi, S., Nomura, S., Nakayama, M., Iizuka, T., Fujiwara, H."Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report". Molecular and Clinical Oncology 21, no. 1 (2024): 50. https://doi.org/10.3892/mco.2024.2748
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