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Molecular and Clinical Oncology
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Case Report Open Access

Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report

  • Authors:
    • Koji Kameyama
    • Kosuke Mizutani
    • Tetsuya Yamada
    • Seiji Sugiyama
    • Shingo Kamei
    • Shigeaki Yokoi
    • Kengo Matsunaga
    • Koseki Hirade
    • Yasutaka Kato
    • Hiroshi Nishihara
    • Satoshi Ishihara
    • Takashi Deguchi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Central Japan International Medical Center, Minokamo, Gifu 505‑8510, Japan, Department of Pathology, Central Japan International Medical Center, Minokamo, Gifu 505‑8510, Japan, Cancer Genomic Testing and Treatment Center, Central Japan International Medical Center, Minokamo, Gifu 505‑8510, Japan, Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo 165‑8582, Japan
    Copyright: © Kameyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 55
    |
    Published online on: June 20, 2024
       https://doi.org/10.3892/mco.2024.2753
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Abstract

Urothelial carcinoma of the bladder with osteoclast‑like giant cells (UCOGCs) is rare among the subtypes of poorly differentiated urothelial carcinoma. Its clinical significance and optimal treatment are unknown, and few reports on genomic analysis of UCOGCs have been reported. Detailed analysis including genetic analysis for rare type variants of cancer could be a foothold for further research. The present case describes the case of a 75‑year‑old man who presented with a non‑papillary bladder tumor 56 mm in diameter showing gross hematuria and pain on voiding. Following transurethral resection of the bladder tumor, the pathological diagnosis was invasive UCOGCs. Neoadjuvant chemotherapy and radical cystectomy were performed with the resected tumor pathologically diagnosed as invasive UCOGCs, high grade, pT3b, pN1. The present study also analyzed the genomic features using a cancer panel test. The panel test noted six gene alterations (PIK3CA p.E542K, HRAS p.G13R, ARAF copy number amplification, CDKN2A copy number loss, TP53 p.E285V, ARID1A p.S90Pfs*11) and telomerase reverse transcriptase (TERT) promoter variant. Accumulation of knowledge from molecular‑based testing is anticipated to determine precise treatment for rare cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kameyama K, Mizutani K, Yamada T, Sugiyama S, Kamei S, Yokoi S, Matsunaga K, Hirade K, Kato Y, Nishihara H, Nishihara H, et al: Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report. Mol Clin Oncol 21: 55, 2024.
APA
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S. ... Deguchi, T. (2024). Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report. Molecular and Clinical Oncology, 21, 55. https://doi.org/10.3892/mco.2024.2753
MLA
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S., Matsunaga, K., Hirade, K., Kato, Y., Nishihara, H., Ishihara, S., Deguchi, T."Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 21.2 (2024): 55.
Chicago
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S., Matsunaga, K., Hirade, K., Kato, Y., Nishihara, H., Ishihara, S., Deguchi, T."Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 21, no. 2 (2024): 55. https://doi.org/10.3892/mco.2024.2753
Copy and paste a formatted citation
x
Spandidos Publications style
Kameyama K, Mizutani K, Yamada T, Sugiyama S, Kamei S, Yokoi S, Matsunaga K, Hirade K, Kato Y, Nishihara H, Nishihara H, et al: Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report. Mol Clin Oncol 21: 55, 2024.
APA
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S. ... Deguchi, T. (2024). Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report. Molecular and Clinical Oncology, 21, 55. https://doi.org/10.3892/mco.2024.2753
MLA
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S., Matsunaga, K., Hirade, K., Kato, Y., Nishihara, H., Ishihara, S., Deguchi, T."Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 21.2 (2024): 55.
Chicago
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S., Matsunaga, K., Hirade, K., Kato, Y., Nishihara, H., Ishihara, S., Deguchi, T."Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 21, no. 2 (2024): 55. https://doi.org/10.3892/mco.2024.2753
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