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Article Open Access

Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis

  • Authors:
    • Jingwen Deng
    • Manman Shi
    • Min Wang
    • Ni Liao
    • Yan Jia
    • Wenliang Lu
    • Feng Yao
    • Shengrong Sun
    • Yimin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Thyroid and Breast Surgery, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei 430070, P.R. China, Department of Medical Ultrasonography, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 60
    |
    Published online on: July 3, 2024
       https://doi.org/10.3892/mco.2024.2758
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Abstract

Early diagnosis is an effective strategy for decreasing breast cancer mortality. Ultrasonography is one of the most predominant imaging modalities for breast cancer owing to its convenience and non‑invasiveness. The present study aimed to develop a model that integrates age with Breast Imaging Reporting and Data System (BI‑RADS) lexicon to improve diagnostic accuracy of ultrasonography in breast cancer. This retrospective study comprised two cohorts: A training cohort with 975 female patients from Renmin Hospital of Wuhan University (Wuhan, China) and a validation cohort with 500 female patients from Maternal and Child Health Hospital of Hubei Province (Wuhan, China). Logistic regression was used to construct a model combining BI‑RADS score with age and to determine the age‑based prevalence of breast cancer to predict a cut‑off age. The model that integrated age with BI‑RADS scores demonstrated the best performance compared with models based solely on age or BI‑RADS scores, with an area under the curve (AUC) of 0.872 (95% CI: 0.850‑0.894, P<0.001). Furthermore, among participants aged <30 years, the prevalence of breast cancer was lower than the lower limit of the reference range (2%) for BI‑RADS subcategory 4A lesions but within the reference range for BI‑RADS category 3 lesions, as indicated by linear regression analysis. Therefore, it is recommended that management for this subset of participants are categorized as BI‑RADS category 3, meaning that biopsies typically indicated could be replaced with short‑term follow‑up. In conclusion, the integrated assessment model based on age and BI‑RADS may enhance accuracy of ultrasonography in diagnosing breast lesions and young patients with BI‑RADS subcategory 4A lesions may be exempted from biopsy.
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1 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023.PubMed/NCBI View Article : Google Scholar

2 

Tagliafico AS, Piana M, Schenone D, Lai R, Massone AM and Houssami N: Overview of radiomics in breast cancer diagnosis and prognostication. Breast. 49:74–80. 2020.PubMed/NCBI View Article : Google Scholar

3 

Bevers TB, Helvie M, Bonaccio E, Calhoun KE, DalyMB FarrarWB, Garber JE, Gray R, Greenberg CC, Greenup R, et al: Breast cancer screening and diagnosis, version 3.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 16:1362–1389. 2018.PubMed/NCBI View Article : Google Scholar

4 

Salmanoglu E, Klinger K, Bhimani C, Sevrukov A and Thakur ML: Advanced approaches to imaging primary breast cancer: An update. Clin Transl Imaging. 7:381–404. 2019.

5 

Chong A, Weinstein SP, McDonald ES and Conant EF: Digital breast tomosynthesis: Concepts and clinical practice. Radiology. 292:1–14. 2019.PubMed/NCBI View Article : Google Scholar

6 

Hou XY, Niu HY, Huang XL and Gao Y: Correlation of breast ultrasound classifications with breast cancer in Chinese women. Ultrasound Med Biol. 42:2616–2621. 2016.PubMed/NCBI View Article : Google Scholar

7 

Devolli-Disha E, Manxhuka-Kërliu S, Ymeri H and Kutllovci A: Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density. Bosn J Basic Med Sci. 9:131–136. 2009.PubMed/NCBI View Article : Google Scholar

8 

Kuhl CK: Abbreviated magnetic resonance imaging (MRI) for breast cancer screening: Rationale, concept, and transfer to clinical practice. Annu Rev Med. 70:501–519. 2019.PubMed/NCBI View Article : Google Scholar

9 

Magny SJ, Shikhman R and Keppke AL: Breast imaging reporting and data system. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL, 2023.

10 

Lazarus E, Mainiero MB, Schepps B, Koelliker SL and Livingston LS: BI-RADS lexicon for US and mammography: Interobserver variability and positive predictive value. Radiology. 239:385–391. 2006.PubMed/NCBI View Article : Google Scholar

11 

He P, Cui LG, Chen W and Yang RL: Subcategorization of ultrasonographic BI-RADS category 4: Assessment of diagnostic accuracy in diagnosing breast lesions and influence of clinical factors on positive predictive value. Ultrasound Med Biol. 45:1253–1258. 2019.PubMed/NCBI View Article : Google Scholar

12 

Hsu W, Zhou X, Petruse A, Chau N, Lee-Felker S, Hoyt A, Wenger N, Elashoff D and Naeim A: Role of clinical and imaging risk factors in predicting breast cancer diagnosis among BI-RADS 4 cases. Clin Breast Cancer. 19:e142–e151. 2019.PubMed/NCBI View Article : Google Scholar

13 

Kang YJ, Ahn SK, Kim SJ, Oh H, Han J and Ko E: Relationship between mammographic density and age in the United Arab Emirates population. J Oncol. 2019(7351350)2019.PubMed/NCBI View Article : Google Scholar

14 

McGuire A, Brown JAL, Malone C, McLaughlin R and Kerin MJ: Effects of age on the detection and management of breast cancer. Cancers (Basel). 7:908–929. 2015.PubMed/NCBI View Article : Google Scholar

15 

Clendenen TV, Ge W, Koenig KL, Afanasyeva Y, Agnoli C, Brinton LA, Darvishian F, Dorgan JF, Eliassen AH, Falk RT, et al: Breast cancer risk prediction in women aged 35-50 years: Impact of including sex hormone concentrations in the gail model. Breast Cancer Research. 21(42)2019.PubMed/NCBI View Article : Google Scholar

16 

DeSantis C, Ma J, Bryan L and Jemal A: Breast cancer statistics, 2013. CA Cancer J Clin. 64:52–62. 2014.PubMed/NCBI View Article : Google Scholar

17 

Leong SP, Shen ZZ, Liu TJ, Agarwal G, Tajima T, Paik NS, Sandelin K, Derossis A, Cody H, Foulkes WD, et al: Is breast cancer the same disease in Asian and Western countries? World J Surg. 34:2308–2324. 2010.PubMed/NCBI View Article : Google Scholar

18 

Spinelli Varella MA, Teixeira da Cruz J, Rauber A, Varella IS, Fleck JF and Moreira LF: Role of BI-RADS ultrasound subcategories 4A to 4C in predicting breast cancer. Clin Breast Cancer. 18:e507–e511. 2018.PubMed/NCBI View Article : Google Scholar

19 

Raza S, Chikarmane SA, Neilsen SS, Zorn LM and Birdwell RL: BI-RADS 3, 4, and 5 lesions: Value of US in managementfollow-up and outcome. Radiology. 248:773–781. 2008.PubMed/NCBI View Article : Google Scholar

20 

Cheung A (ed): WHO classification of tumours 5th edition. World Health Organization, Geneva, 2018.

21 

Lei S, Zheng R, Zhang S, Chen R, Wang S, Sun K, Zeng H, Wei W and He J: Breast cancer incidence and mortality in women in China: Temporal trends and projections to 2030. Cancer Biol Med. 18:900–909. 2021.PubMed/NCBI View Article : Google Scholar

22 

Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM and Goss PE: Breast cancer in China. Lancet Oncol. 15:e279–e289. 2014.PubMed/NCBI View Article : Google Scholar

23 

Li JW, Zhang K, Shi ZT, Zhang X, Xie J, Liu JY and Chang C: Triple-negative invasive breast carcinoma: The association between the sonographic appearances with clinicopathological feature. Sci Rep. 8(9040)2018.PubMed/NCBI View Article : Google Scholar

24 

Tian L, Wang L, Qin Y and Cai J: Systematic review and meta-analysis of the malignant ultrasound features of triple-negative breast cancer. J Ultrasound Med. 39:2013–2025. 2020.PubMed/NCBI View Article : Google Scholar

25 

Wojcinski S, Soliman AA, Schmidt J, Makowski L, Degenhardt F and Hillemanns P: Sonographic features of triple-negative and non-triple-negative breast cancer. J Ultrasound Med. 31:1531–1541. 2012.PubMed/NCBI View Article : Google Scholar

26 

Wang K, Zou Z, Shen H, Huang G and Yang S: Calcification, posterior acoustic, and blood flow: Ultrasonic characteristics of triple-negative breast cancer. J Healthc Eng. 2022(9336185)2022.PubMed/NCBI View Article : Google Scholar

27 

Fu CY, Hsu HH, Yu JC, Hsu GC, Hsu KF, Chan DC, Ku CH, Lu TC and Chu CH: Influence of age on PPV of sonographic BI-RADS categories 3, 4, and 5. Ultraschall Med. 32 (Suppl 1):S8–S13. 2011.PubMed/NCBI View Article : Google Scholar

28 

Hu Y, Yang Y, Gu R, Jin L, Shen S, Liu F, Wang H, Mei J, Jiang X, Liu Q and Su F: Does patient age affect the PPV3 of ACR BI-RADS ultrasound categories 4 and 5 in the diagnostic setting? Eur Radiol. 28:2492–2498. 2018.PubMed/NCBI View Article : Google Scholar

29 

Noonpradej S, Wangkulangkul P, Woodtichartpreecha P and Laohawiriyakamol S: Prediction for breast cancer in BI-RADS category 4 lesion categorized by age and breast composition of women in Songklanagarind hospital. Asian Pac J Cancer Prev. 22:531–536. 2021.PubMed/NCBI View Article : Google Scholar

30 

Xie Y, Zhu Y, Chai W, Zong S, Xu S, Zhan W and Zhang X: Downgrade BI-RADS 4A patients using nomogram based on breast magnetic resonance imaging, ultrasound, and mammography. Front Oncol. 12(807402)2022.PubMed/NCBI View Article : Google Scholar

31 

Engmann NJ, Golmakani MK, Miglioretti DL, Sprague BL and Kerlikowske K: Breast Cancer Surveillance Consortium. Population-attributable risk proportion of clinical risk factors for breast cancer. JAMA Oncol. 3:1228–1236. 2017.PubMed/NCBI View Article : Google Scholar

32 

Corsetti V, Houssami N, Ferrari A, Ghirardi M, Bellarosa S, Angelini O, Bani C, Sardo P, Remida G, Galligioni E and Ciatto S: Breast screening with ultrasound in women with mammography-negative dense breasts: Evidence on incremental cancer detection and false positives, and associated cost. Eur J Cancer. 44:539–544. 2008.PubMed/NCBI View Article : Google Scholar

33 

Le EPV, Wang Y, Huang Y, Hickman S and Gilbert FJ: Artificial intelligence in breast imaging. Clin Radiol. 74:357–366. 2019.PubMed/NCBI View Article : Google Scholar

34 

Lei YM, Yin M, Yu MH, Yu J, Zeng SE, Lv WZ, Li J, Ye HR, Cui XW and Dietrich CF: Artificial intelligence in medical imaging of the breast. Front Oncol. 11(600557)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Deng J, Shi M, Wang M, Liao N, Jia Y, Lu W, Yao F, Sun S and Zhang Y: Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis. Mol Clin Oncol 21: 60, 2024.
APA
Deng, J., Shi, M., Wang, M., Liao, N., Jia, Y., Lu, W. ... Zhang, Y. (2024). Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis. Molecular and Clinical Oncology, 21, 60. https://doi.org/10.3892/mco.2024.2758
MLA
Deng, J., Shi, M., Wang, M., Liao, N., Jia, Y., Lu, W., Yao, F., Sun, S., Zhang, Y."Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis". Molecular and Clinical Oncology 21.3 (2024): 60.
Chicago
Deng, J., Shi, M., Wang, M., Liao, N., Jia, Y., Lu, W., Yao, F., Sun, S., Zhang, Y."Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis". Molecular and Clinical Oncology 21, no. 3 (2024): 60. https://doi.org/10.3892/mco.2024.2758
Copy and paste a formatted citation
x
Spandidos Publications style
Deng J, Shi M, Wang M, Liao N, Jia Y, Lu W, Yao F, Sun S and Zhang Y: Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis. Mol Clin Oncol 21: 60, 2024.
APA
Deng, J., Shi, M., Wang, M., Liao, N., Jia, Y., Lu, W. ... Zhang, Y. (2024). Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis. Molecular and Clinical Oncology, 21, 60. https://doi.org/10.3892/mco.2024.2758
MLA
Deng, J., Shi, M., Wang, M., Liao, N., Jia, Y., Lu, W., Yao, F., Sun, S., Zhang, Y."Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis". Molecular and Clinical Oncology 21.3 (2024): 60.
Chicago
Deng, J., Shi, M., Wang, M., Liao, N., Jia, Y., Lu, W., Yao, F., Sun, S., Zhang, Y."Age‑integrated breast imaging reporting and data system assessment model to improve the accuracy of breast cancer diagnosis". Molecular and Clinical Oncology 21, no. 3 (2024): 60. https://doi.org/10.3892/mco.2024.2758
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