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Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer

  • Authors:
    • Keisuke Usui
    • Anneyuko I. Saito
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Faculty of Medicine, Juntendo University, Tokyo 113‑8421, Japan
    Copyright: © Usui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 68
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    Published online on: July 24, 2024
       https://doi.org/10.3892/mco.2024.2766
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Abstract

The treatment outcomes of patients with unresectable rectal cancer are complex, and concurrent chemoradiation therapy is the main treatment option. Radiosensitizers can enhance the effect of localized intratumoral hypoxia, contributing to local control and symptomatic relief. The present study evaluated the feasibility and safety of radiosensitization using hydrogen peroxide combined with radiation therapy (RT) in patients with unresectable rectal cancer. A total of 13 patients with rectal cancer were recruited in the present study. Radiosensitization was performed twice weekly in combination with RT. Gauze soaked in 3% hydrogen peroxide solution was inserted into the anus, ensuring firm contact with the lesion. In total, 45‑65 Gy was delivered in 25‑33 fractions to the whole pelvis from four directions using 10 MV X‑rays 5 days per week. Acute and late adverse events were evaluated 1 and 6 months after the completion of RT. Treatment was well tolerated, with no acute grade 3 or worse events noted, and no patient developed rectal fistula, necrosis, obstruction, perforation, stenosis, ulcer or retroperitoneal hemorrhage. No notable late adverse events, beyond 6 months, were observed at the end of the analysis. All patients experienced pain relief, hemostatic effects and tumor shrinkage. Therefore, the use of a hydrogen peroxide solution‑soaked gauze in the rectum may be a promising option for patients with inoperable rectal tumors. The limitations of the present study are that the patient population was small and the observation time was relatively short. This study was retrospectively registered with the University Hospital Medical Information Network Center (trial registration no. R000061902) on April 21, 2024.
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Copy and paste a formatted citation
Spandidos Publications style
Usui K and Saito AI: Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer. Mol Clin Oncol 21: 68, 2024.
APA
Usui, K., & Saito, A.I. (2024). Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer. Molecular and Clinical Oncology, 21, 68. https://doi.org/10.3892/mco.2024.2766
MLA
Usui, K., Saito, A. I."Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer". Molecular and Clinical Oncology 21.4 (2024): 68.
Chicago
Usui, K., Saito, A. I."Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer". Molecular and Clinical Oncology 21, no. 4 (2024): 68. https://doi.org/10.3892/mco.2024.2766
Copy and paste a formatted citation
x
Spandidos Publications style
Usui K and Saito AI: Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer. Mol Clin Oncol 21: 68, 2024.
APA
Usui, K., & Saito, A.I. (2024). Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer. Molecular and Clinical Oncology, 21, 68. https://doi.org/10.3892/mco.2024.2766
MLA
Usui, K., Saito, A. I."Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer". Molecular and Clinical Oncology 21.4 (2024): 68.
Chicago
Usui, K., Saito, A. I."Radiosensitization treatment using hydrogen peroxide for inoperable rectal cancer". Molecular and Clinical Oncology 21, no. 4 (2024): 68. https://doi.org/10.3892/mco.2024.2766
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