Epidermal inclusion cyst in an axillary lymph node with breast cancer: A case report

Abdullah,Ari M.; Omar,Sami Saleem; Qadir,Abdullah A.; Salih,Abdulwahid M.; Pshtiwan,Lana R.A.; Ahmed,Ronak Saeed; Ali,Rawa M.; Baba,Hiwa O.; Mohammed,Rebaz O.; Ali,Halkawt Omar; Kakamad,Fahmi Hussein

doi:10.3892/mco.2024.2769

October-2024 Volume 21 Issue 4

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October-2024 Volume 21 Issue 4

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Case Report Open Access

Epidermal inclusion cyst in an axillary lymph node with breast cancer: A case report

Authors:
- Ari M. Abdullah
- Sami Saleem Omar
- Abdullah A. Qadir
- Abdulwahid M. Salih
- Lana R.A. Pshtiwan
- Ronak Saeed Ahmed
- Rawa M. Ali
- Hiwa O. Baba
- Rebaz O. Mohammed
- Halkawt Omar Ali
- Fahmi Hussein Kakamad
View Affiliations / Copyright

Affiliations: Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah, Kurdistan 46001, Iraq, Kscien Organization for Scientific Research, Sulaymaniyah, Kurdistan 46001, Iraq

Copyright: © Abdullah et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 72
|
Published online on: August 2, 2024

https://doi.org/10.3892/mco.2024.2769
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Abstract

Epidermal inclusion cyst (EIC) is a benign lesion rarely discovered within lymph nodes. The present case report introduces an EIC incidentally discovered during an axillary lymph node biopsy in a patient with invasive ductal carcinoma of the breast. A 55‑year‑old woman presented with a breast mass. Ultrasound revealed a suspicious mass, and a core needle biopsy confirmed the diagnosis of invasive ductal carcinoma. Lumpectomy and sentinel lymph node biopsies were performed. Histopathological examination revealed tumor‑free lymph nodes, with one of them harboring a keratinous EIC. EICs typically arise from entrapped epidermal cells. Their presence in lymph nodes is exceptionally rare. While the origin of such inclusions remains unclear, various theories exist, including anomalous embryonic development, implantation, and metaplasia. This report highlights the unique presentation of an EIC within an axillary lymph node. Recognizing this entity is crucial to avoid misdiagnosis of malignancy and unnecessary interventions.

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1	Zito P and Schar FC: Epidermoid (Sebaceous Cyst). StatPearls StatPearls Publishing, Treasure Island, FL, 2019.
2	Hoang VT, Trinh CT, Nguyen CH, Chansomphou V, Chansomphou V and Tran TTT: Overview of Epidermal cyst. Eur J Radiol Open. 6:291–301. 2019.PubMed/NCBI View Article : Google Scholar
3	Abu-Mandeel E, Saadeh A, Rababaa H and Al-Share MS: Epidermal inclusion cyst of the axilla with calcifications. Radiol Case Rep. 18:784–787. 2022.PubMed/NCBI View Article : Google Scholar
4	Sigei AC, Bartow BB and Wheeler Y: Sentinel lymph node involvement by epithelial inclusions mimicking metastatic carcinoma: A diagnostic pitfall. Am J Case Rep. 21(e926094)2020.PubMed/NCBI View Article : Google Scholar
5	Lee JY: Giant epidermal inclusion cyst of the axilla: A case report with diagnostic ultrasound imaging features. Radiol Case Rep. 17:64–67. 2021.PubMed/NCBI View Article : Google Scholar
6	Abdullah AS, Ahmed AG, Mohammed SN, Qadir AA, Bapir NM and Fatah GM: Benign Tumor Publication in One Year (2022): A Cross-Sectional Study. Barw Med J. 1:20–25. 2023.
7	Weir CB and St Hilaire NJ: Epidermal Inclusion Cyst. In: StatPearls. StatPearls Publishing, Treasure Island, FL, 2023.
8	Kini YK, Kharkar VR, Rudagi BM and Kalburge JV: An unusual occurrence of epidermoid cyst in the buccal mucosa: A case report with review of literature. J Maxillofac Oral Surg. 12:90–93. 2013.PubMed/NCBI View Article : Google Scholar
9	Spinardi JR, Goncalves IRD, La Falce TS, Fregnani JHTG, Barros MD and Macea JR: Benign inclusions in lymph nodes. Int J Morphol. 25:625–629. 2007.
10	Fellegara G, Carcangiu ML and Rosai J: Benign epithelial inclusions in axillary lymph nodes: Report of 18 cases and review of the literature. Am J Surg Pathol. 35:1123–1133. 2011.PubMed/NCBI View Article : Google Scholar
11	Bahadur S, Pujani M and Jetley S: Epithelial inclusion cyst in a cervical lymph node: Report of a rare entity at an uncommon location. Ann Med Health Sci Res. 6:137–138. 2016.PubMed/NCBI View Article : Google Scholar
12	Abdullah HO, Abdalla BA, Kakamad FH, Ahmed JO, Baba HO, Hassan MN, Bapir R, Rahim HM, Omar DA, Kakamad SH, et al: Predatory Publishing Lists: A Review on the Ongoing Battle Against Fraudulent Actions. Barw Med J. 2:26–30. 2024.
13	Sreeramulu PN, Khan NA, Sreenivasan D and Gopinath K: Epidermal Cyst in the Breast: A Diagnostic Dilemma. Indian J Surg Oncol. 8:417–419. 2017.PubMed/NCBI View Article : Google Scholar
14	Mingomataj E, Krasniqi M, Dedushi K, Sergeevich KA, Kust D and Qadir AA: Cancer Publications in One Year (2023): A Cross-Sectional Study. Barw Med J. 2:3–11. 2024.
15	Fisher CJ, Hill S and Millis RR: Benign lymph node inclusions mimicking metastatic carcinoma. J Clin Pathol. 47:245–247. 1994.PubMed/NCBI View Article : Google Scholar
16	Hunter NB, Rousseau M, Nelson EE and Rashid RM: The First Report of Multiple, Bilateral Axillary Epidermal Inclusion Cysts. Cureus. 16(e55640)2024.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Epidermal inclusion cyst in an axillary lymph node with breast cancer: A case report

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