Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2024 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2024 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

IL1RL2 is related to the expression and prognosis of bladder cancer

  • Authors:
    • Xuemei Ha
    • Yue Li
    • Zihui Gao
    • Jiazhao Cui
    • Yuzhu Nie
    • Lihua Sun
    • Wenzhi Gao
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Peking University First Hospital‑Miyun Hospital, Beijing 100034, P.R. China, Department of Urology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Ha et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 75
    |
    Published online on: August 13, 2024
       https://doi.org/10.3892/mco.2024.2773
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

IL1RL2 has been reported to be highly expressed in a variety of tumor types whereas its role in bladder cancer (BLCA) remains unclear. The aim of the present study was to explore the prognostic value of Il1RL2 in BLCA and its relationship with clinical pathological features. The Cancer Genome Atlas (TCGA) database was used to assess the levels of IL1RL2 expression in BLCA tissues and cells, which were validated by reverse transcription‑quantitative polymerase chain reaction and western blotting. Immunohistochemistry was employed to analyze expression of the IL1RL2 gene in 17 pairs of tumor and normal specimens, as well as 112 samples with different stages and grades of tumors. To investigate the biological functions of Il1RL2 in BLCA, co‑expression networks and functional enrichment analyses were conducted. A protein‑protein interaction network was constructed using interaction gene search tools. IL1RL2 was revealed to be clearly expressed in BLCA cells and tissues. The area under the curve for amplification of IL1RL2 distinguishing between tumor and normal tissues was 0.700 (95% CI: 0.579‑0.821) in the TCGA database and 0.647 (95% CI: 0.497‑0.797) in Miyun chart database, respectively. Furthermore, in our database, both univariate and multivariate analyses indicated that IL1RL2 expression was an independent risk factor for overall survival (OS). Kaplan‑Meier survival analysis revealed an association between high IL1RL2 expression and low OS. Pathway enrichment analysis suggested that IL1RL2 is involved in the regulation of tumor progression through the MAPK signaling pathway. The expression level of IL1RL2 was associated with the stage, grade, lymph node album and prognosis of BLCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

2 

Li K and Lin T: Chinese Bladder Cancer Consortium. Xue W, Mu X, Xu E, Yang X, Chen F, Li G, Ma L, et al: Current status of diagnosis and treatment of bladder cancer in China-analyses of Chinese bladder cancer consortium database. Asian J Urol. 2:63–69. 2015.PubMed/NCBI View Article : Google Scholar

3 

Lobo N, Afferi L, Moschini M, Mostafid H, Porten S, Psutka SP, Gupta S, Smith AB, Williams SB and Lotan Y: Epidemiology, screening, and prevention of bladder cancer. Eur Urol Oncol. 5:628–639. 2022.PubMed/NCBI View Article : Google Scholar

4 

Chen H, Yang W, Xue X, Li Y, Jin Z and Ji Z: Integrated analysis revealed an inflammatory cancer-associated fibroblast-based subtypes with promising implications in predicting the prognosis and immunotherapeutic response of bladder cancer patients. Int J Mol Sci. 23(15970)2022.PubMed/NCBI View Article : Google Scholar

5 

Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH, et al: European association of urology guidelines on non-muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ). Eur Urol. 81:75–94. 2022.PubMed/NCBI View Article : Google Scholar

6 

Stein JP and Skinner DG: Radical cystectomy for invasive bladder cancer: Long-term results of a standard procedure. World J Urol. 24:296–304. 2006.PubMed/NCBI View Article : Google Scholar

7 

Witjes JA, Bruins HM, Cathomas R, Compérat EM, Cowan NC, Gakis G, Hernández V, Linares Espinós E, Lorch A, Neuzillet Y, et al: European association of urology guidelines on muscle-invasive and metastatic bladder cancer: Summary of the 2020 guidelines. Eur Urol. 79:82–104. 2021.PubMed/NCBI View Article : Google Scholar

8 

Dale M and Nicklin MJ: Interleukin-1 receptor cluster: Gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics. 57:177–179. 1999.PubMed/NCBI View Article : Google Scholar

9 

Ngo VL, Kuczma M, Maxim E and Denning TL: Il-36 cytokines and gut immunity. Immunology. 163:145–154. 2021.PubMed/NCBI View Article : Google Scholar

10 

Tomuschat C, O'Donnell AM, Coyle D and Puri P: Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease. Pediatr Surg Int. 33:181–186. 2017.PubMed/NCBI View Article : Google Scholar

11 

Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, et al: Inhibiting interleukin 36 receptor signaling reduces fibrosis in mice with chronic intestinal inflammation. Gastroenterology. 156:1082–1097.e11. 2019.PubMed/NCBI View Article : Google Scholar

12 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011.PubMed/NCBI View Article : Google Scholar

13 

Baker KJ, Brint E and Houston A: Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/IL-23 axis. Br J Cancer. 128:735–747. 2023.PubMed/NCBI View Article : Google Scholar

14 

Poudel M, Bhattarai PY, Shrestha P and Choi HS: Regulation of interleukin-36γ/IL-36R signaling axis by PIN1 in epithelial cell transformation and breast tumorigenesis. Cancers (Basel). 14(3654)2022.PubMed/NCBI View Article : Google Scholar

15 

Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, et al: IL-36γ and IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death. Adv Sci (Weinh). 8(e2101501)2021.PubMed/NCBI View Article : Google Scholar

16 

Kovach MA, Che K, Brundin B, Andersson A, Asgeirsdottir H, Padra M, Lindén SK, Qvarfordt I, Newstead MW, Standiford TJ and Lindén A: IL-36 cytokines promote inflammation in the lungs of long-term smokers. Am J Respir Cell Mol Biol. 64:173–182. 2021.PubMed/NCBI View Article : Google Scholar

17 

Goldman MJ, Craft B, Hastie M, Repečka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, et al: Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 38:675–678. 2020.PubMed/NCBI View Article : Google Scholar

18 

Guo Q, Zhao L, Yan N, Li Y, Guo C, Dang S, Shen X, Han J and Luo Y: Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer. Front Immunol. 14(1148056)2023.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Dyrskjøt L, Hansel DE, Efstathiou JA, Knowles MA, Galsky MD, Teoh J and Theodorescu D: Bladder cancer. Nat Rev Dis Primers. 9(58)2023.PubMed/NCBI View Article : Google Scholar

21 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021.PubMed/NCBI View Article : Google Scholar

22 

Lokeshwar VB and Soloway MS: Current bladder tumor tests: Does their projected utility fulfill clinical necessity? J Urol. 165:1067–1077. 2001.PubMed/NCBI

23 

Grossman HB, Messing E, Soloway M, Tomera K, Katz G, Berger Y and Shen Y: Detection of bladder cancer using a point-of-care proteomic assay. JAMA. 293:810–816. 2005.PubMed/NCBI View Article : Google Scholar

24 

Wen S, He L, Zhong Z, Mi H and Liu F: Prognostic model of colorectal cancer constructed by eight immune-related genes. Front Mol Biosci. 7(604252)2020.PubMed/NCBI View Article : Google Scholar

25 

Chen YC, Gonzalez ME, Burman B, Zhao X, Anwar T, Tran M, Medhora N, Hiziroglu AB, Lee W, Cheng YH, et al: Mesenchymal stem/stromal cell engulfment reveals metastatic advantage in breast cancer. Cell Rep. 27:3916–3926.e5. 2019.PubMed/NCBI View Article : Google Scholar

26 

Hao M, Li H, Yi M, Zhu Y, Wang K, Liu Y, Liang X and Ding L: Development of an immune-related gene prognostic risk model and identification of an immune infiltration signature in the tumor microenvironment of colon cancer. BMC Gastroenterol. 23(58)2023.PubMed/NCBI View Article : Google Scholar

27 

Baker KJ, Buskiewicz E, Finucane M, Chelliah A, Burke L, Houston A and Brint E: IL-36 expression is increased in NSCLC with IL-36 stimulation of lung cancer cells promoting a pro-tumorigenic phenotype. Cytokine. 165(156170)2023.PubMed/NCBI View Article : Google Scholar

28 

Drosten M and Barbacid M: Targeting the MAPK pathway in KRAS-driven tumors. Cancer Cell. 37:543–550. 2020.PubMed/NCBI View Article : Google Scholar

29 

Ullah R, Yin Q, Snell AH and Wan L: RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol. 85:123–154. 2022.PubMed/NCBI View Article : Google Scholar

30 

Lee S, Rauch J and Kolch W: Targeting MAPK signaling in cancer: Mechanisms of drug resistance and sensitivity. Int J Mol Sci. 21(1102)2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ha X, Li Y, Gao Z, Cui J, Nie Y, Sun L and Gao W: IL1RL2 is related to the expression and prognosis of bladder cancer. Mol Clin Oncol 21: 75, 2024.
APA
Ha, X., Li, Y., Gao, Z., Cui, J., Nie, Y., Sun, L., & Gao, W. (2024). IL1RL2 is related to the expression and prognosis of bladder cancer. Molecular and Clinical Oncology, 21, 75. https://doi.org/10.3892/mco.2024.2773
MLA
Ha, X., Li, Y., Gao, Z., Cui, J., Nie, Y., Sun, L., Gao, W."IL1RL2 is related to the expression and prognosis of bladder cancer". Molecular and Clinical Oncology 21.4 (2024): 75.
Chicago
Ha, X., Li, Y., Gao, Z., Cui, J., Nie, Y., Sun, L., Gao, W."IL1RL2 is related to the expression and prognosis of bladder cancer". Molecular and Clinical Oncology 21, no. 4 (2024): 75. https://doi.org/10.3892/mco.2024.2773
Copy and paste a formatted citation
x
Spandidos Publications style
Ha X, Li Y, Gao Z, Cui J, Nie Y, Sun L and Gao W: IL1RL2 is related to the expression and prognosis of bladder cancer. Mol Clin Oncol 21: 75, 2024.
APA
Ha, X., Li, Y., Gao, Z., Cui, J., Nie, Y., Sun, L., & Gao, W. (2024). IL1RL2 is related to the expression and prognosis of bladder cancer. Molecular and Clinical Oncology, 21, 75. https://doi.org/10.3892/mco.2024.2773
MLA
Ha, X., Li, Y., Gao, Z., Cui, J., Nie, Y., Sun, L., Gao, W."IL1RL2 is related to the expression and prognosis of bladder cancer". Molecular and Clinical Oncology 21.4 (2024): 75.
Chicago
Ha, X., Li, Y., Gao, Z., Cui, J., Nie, Y., Sun, L., Gao, W."IL1RL2 is related to the expression and prognosis of bladder cancer". Molecular and Clinical Oncology 21, no. 4 (2024): 75. https://doi.org/10.3892/mco.2024.2773
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team