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Gastric cancer and brain metastasis: A systematic review and meta‑analysis

  • Authors:
    • George Fotakopoulos
    • Grigorios Christodoulidis
    • Vasiliki Epameinondas Georgakopoulou
    • Nikolaos Trakas
    • Pagona Skapani
    • Konstantinos Panagiotopoulos
    • Demetrios A. Spandidos
    • Nicolas Foroglou
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece, Department of General Surgery, General University Hospital of Larisa, 41221 Larisa, Greece, Department of Pathophysiology, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Biochemistry Laboratory, General Hospital of Athens ‘Georgios Gennimatas’, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, First Department of Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
    Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 77
    |
    Published online on: August 19, 2024
       https://doi.org/10.3892/mco.2024.2775
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Abstract

Gastric cancer (GC) constitutes one of the most wide‑ranging cancers, with brain metastasis (BM) being a markedly uncommon and unfavorable outcome. The present meta‑analysis evaluated the relationship between no‑surgical treatment vs. additional surgical BM resection on the patient's quality of life and potential survival using electronic databases, including PubMed (1980‑April 2024), Medline (1980‑April 2024), Cochrane Library, and EMBASE (1980‑April 2024). After a literature search, six articles were included in the final study pool. The number of patients with BM and conservative treatment was 289 (80.05%) compared with those that underwent an additional surgical resection 72 (19.95%). The mean age was 59.2 years, and the males were 195 (73.8%) of 264 available from five studies. The findings of the present meta‑analysis revealed that the curative effect of BM tumor resection on patients with GC undergoing additional treatment with stereotactic radiosurgery, whole‑brain radiotherapy or chemotherapy was favorable for their survival.
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Copy and paste a formatted citation
Spandidos Publications style
Fotakopoulos G, Christodoulidis G, Georgakopoulou VE, Trakas N, Skapani P, Panagiotopoulos K, Spandidos DA and Foroglou N: Gastric cancer and brain metastasis: A systematic review and meta‑analysis. Mol Clin Oncol 21: 77, 2024.
APA
Fotakopoulos, G., Christodoulidis, G., Georgakopoulou, V.E., Trakas, N., Skapani, P., Panagiotopoulos, K. ... Foroglou, N. (2024). Gastric cancer and brain metastasis: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 21, 77. https://doi.org/10.3892/mco.2024.2775
MLA
Fotakopoulos, G., Christodoulidis, G., Georgakopoulou, V. E., Trakas, N., Skapani, P., Panagiotopoulos, K., Spandidos, D. A., Foroglou, N."Gastric cancer and brain metastasis: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21.5 (2024): 77.
Chicago
Fotakopoulos, G., Christodoulidis, G., Georgakopoulou, V. E., Trakas, N., Skapani, P., Panagiotopoulos, K., Spandidos, D. A., Foroglou, N."Gastric cancer and brain metastasis: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21, no. 5 (2024): 77. https://doi.org/10.3892/mco.2024.2775
Copy and paste a formatted citation
x
Spandidos Publications style
Fotakopoulos G, Christodoulidis G, Georgakopoulou VE, Trakas N, Skapani P, Panagiotopoulos K, Spandidos DA and Foroglou N: Gastric cancer and brain metastasis: A systematic review and meta‑analysis. Mol Clin Oncol 21: 77, 2024.
APA
Fotakopoulos, G., Christodoulidis, G., Georgakopoulou, V.E., Trakas, N., Skapani, P., Panagiotopoulos, K. ... Foroglou, N. (2024). Gastric cancer and brain metastasis: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 21, 77. https://doi.org/10.3892/mco.2024.2775
MLA
Fotakopoulos, G., Christodoulidis, G., Georgakopoulou, V. E., Trakas, N., Skapani, P., Panagiotopoulos, K., Spandidos, D. A., Foroglou, N."Gastric cancer and brain metastasis: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21.5 (2024): 77.
Chicago
Fotakopoulos, G., Christodoulidis, G., Georgakopoulou, V. E., Trakas, N., Skapani, P., Panagiotopoulos, K., Spandidos, D. A., Foroglou, N."Gastric cancer and brain metastasis: A systematic review and meta‑analysis". Molecular and Clinical Oncology 21, no. 5 (2024): 77. https://doi.org/10.3892/mco.2024.2775
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