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Targeting signaling pathways with andrographolide in cancer therapy (Review)

  • Authors:
    • Nur Shahirah Shaharudin
    • Gurmeet Kaur Surindar Singh
    • Teh Lay Kek
    • Sadia Sultan
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia, Department of Pharmacology and Life Sciences, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia
    Copyright: © Shaharudin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 81
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    Published online on: September 5, 2024
       https://doi.org/10.3892/mco.2024.2779
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Abstract

Terpenoids are a large group of naturally occurring organic compounds with a wide range of components. A phytoconstituent in this group, andrographolide, which is derived from a plant called Andrographis paniculate, offers a number of advantages, including anti‑inflammatory, anticancer, anti‑angiogenesis and antioxidant effects. The present review elucidates the capacity of andrographolide to inhibit signaling pathways, namely the nuclear factor‑κB (NF‑κB), hypoxia‑inducible factor 1 (HIF‑1), the Janus kinase (JAK)/signal transducer and activator of transcription (STAT), phosphatidylinositol‑3‑kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR), Wnt/β‑catenin and mitogen‑activated protein kinase (MAPK) pathways, which are involved in cellular processes and responses such as the inflammatory response, apoptosis and angiogenesis. Inhibiting pathways enables andrographolide to exhibit its anticancer effects against breast, colorectal and lung cancer. The present review focuses on the anticancer effects of andrographolide, specifically in breast, colorectal and lung cancer through the NF‑κB, HIF‑1 and JAK/STAT signaling pathways. Therefore, the Google Scholar, PubMed and ScienceDirect databases were used to search for references to these prevalent types of cancer and the anticancer mechanisms of andrographolide associated with them. The following key words were used: Andrographolide, anticancer, JAK/STAT, HIF‑1, NF‑κB, PI3K/AKT/mTOR, Wnt/β‑catenin and MAPK pathways, and the literature was limited to studies published between 2010 to 2023. The present review article provides details about the different involvements of signaling pathways in the anticancer mechanisms of andrographolide.
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Spandidos Publications style
Shaharudin N, Surindar Singh G, Kek TL and Sultan S: Targeting signaling pathways with andrographolide in cancer therapy (Review). Mol Clin Oncol 21: 81, 2024.
APA
Shaharudin, N., Surindar Singh, G., Kek, T.L., & Sultan, S. (2024). Targeting signaling pathways with andrographolide in cancer therapy (Review). Molecular and Clinical Oncology, 21, 81. https://doi.org/10.3892/mco.2024.2779
MLA
Shaharudin, N., Surindar Singh, G., Kek, T. L., Sultan, S."Targeting signaling pathways with andrographolide in cancer therapy (Review)". Molecular and Clinical Oncology 21.5 (2024): 81.
Chicago
Shaharudin, N., Surindar Singh, G., Kek, T. L., Sultan, S."Targeting signaling pathways with andrographolide in cancer therapy (Review)". Molecular and Clinical Oncology 21, no. 5 (2024): 81. https://doi.org/10.3892/mco.2024.2779
Copy and paste a formatted citation
x
Spandidos Publications style
Shaharudin N, Surindar Singh G, Kek TL and Sultan S: Targeting signaling pathways with andrographolide in cancer therapy (Review). Mol Clin Oncol 21: 81, 2024.
APA
Shaharudin, N., Surindar Singh, G., Kek, T.L., & Sultan, S. (2024). Targeting signaling pathways with andrographolide in cancer therapy (Review). Molecular and Clinical Oncology, 21, 81. https://doi.org/10.3892/mco.2024.2779
MLA
Shaharudin, N., Surindar Singh, G., Kek, T. L., Sultan, S."Targeting signaling pathways with andrographolide in cancer therapy (Review)". Molecular and Clinical Oncology 21.5 (2024): 81.
Chicago
Shaharudin, N., Surindar Singh, G., Kek, T. L., Sultan, S."Targeting signaling pathways with andrographolide in cancer therapy (Review)". Molecular and Clinical Oncology 21, no. 5 (2024): 81. https://doi.org/10.3892/mco.2024.2779
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