Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2024 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas

  • Authors:
    • Guangzhi Hao
    • Bingying Zhang
    • Yuanyuan Li
    • Yue Wu
    • Yuwei Han
    • Xiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China, Second Stationed Out‑Patient Department, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 83
    |
    Published online on: September 9, 2024
       https://doi.org/10.3892/mco.2024.2781
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hemangioblastoma is a rare benign vascular tumor that occurs mostly in the cerebellum. The aim of the present study was to analyze the clinical characteristics of sporadic cerebellar hemangioblastoma and its surgical strategy. A total of 76 cases of sporadic cerebellar hemangioblastoma (42 males and 34 females; age, 46.4±13.9 years; age range, 23‑72 years) admitted to the Department of Neurosurgery of the General Hospital of Northern Theater Command (Shenyang, China) from July 2012 to April 2021 were retrospectively analyzed. All patients had only one isolated tumor and underwent surgical resection. Their basic characteristics, serial radiographic examinations, surgical records and follow‑up were analyzed. A total of 57 patients with cystic hemangioblastoma and eight patients with cystic solid hemangioblastoma directly underwent resection treatment. Of 11 patients with solid hemangioblastoma, 8 underwent vascular embolization prior to surgical resection. Furthermore, 3 patients with solid hemangioblastoma who were not embolized prior to surgery had intraoperative hemorrhage and poor prognosis. In addition, 3 patients underwent partial resection of the tumor and all of them suffered recurrence after the surgery. A total of 71 patients achieved good neurologic improvement. However, 5 patients had a poor prognosis after the initial surgery. In conclusion, total microsurgical resection is essential to improve the health status of patients with sporadic cerebellar cystic hemangioblastoma. In addition, preoperative embolization of arteries supplying solid hemangioblastomas can reduce intraoperative bleeding and improve prognosis.
View Figures

Figure 1

Figure 2

View References

1 

Ma D, Wang Y, Du G and Zhou L: Neurosurgical management of brainstem hemangioblastomas: A single-institution experience with 116 patients. World Neurosurg. 84:1030–1038. 2015.PubMed/NCBI View Article : Google Scholar

2 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016.PubMed/NCBI View Article : Google Scholar

3 

Lonser RR, Butman JA, Huntoon K, Asthagiri AR, Wu T, Bakhtian KD, Chew EY, Zhuang Z, Linehan WM and Oldfield EH: Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease. J Neurosurg. 120:1055–1062. 2014.PubMed/NCBI View Article : Google Scholar

4 

Sun Z, Yuan D, Sun Y, Yan P and Zuo H: Surgical resection of cerebellar hemangioblastoma with enhanced wall thickness: A report of two cases. Oncol Lett. 9:1597–1599. 2015.PubMed/NCBI View Article : Google Scholar

5 

Fukuda M, Takao T, Hiraishi T, Yoshimura J, Yajima N, Saito A and Fujii Y: Clinical factors predicting outcomes after surgical resection for sporadic cerebellar hemangioblastomas. World Neurosurg. 82:815–821. 2014.PubMed/NCBI View Article : Google Scholar

6 

Cheng J, Liu W, Hui X, Zhang S and Ju Y: Pediatric central nervous system hemangioblastomas: Different from adult forms? A retrospective series of 25 cases. Acta Neurochir (Wien). 159:1603–1611. 2017.PubMed/NCBI View Article : Google Scholar

7 

Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM and Oldfield EH: von Hippel-Lindau disease. Lancet. 361:2059–2067. 2003.PubMed/NCBI View Article : Google Scholar

8 

Ammerman JM, Lonser RR, Dambrosia J, Butman JA and Oldfield EH: Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: Implications for treatment. J Neurosurg. 105:248–255. 2006.PubMed/NCBI View Article : Google Scholar

9 

Husain Q, Ghosh D, Vasdev A, Eloy JA and Liu JK: Hemangioblastomas of the central nervous system in von Hippel-Lindau disease: Review of the literature and a single institution experience. Neurosurg Focus. 35(E8)2013.

10 

Pichierri A, Di Bonaventura R, Spagnuolo C, Ruggeri AG, Del Maestro M, Sturiale CL and Albanese A: Surgical management of cerebellar hemangioblastomas: Report of 8 cases. J Neurosurg Sci. 60:72–81. 2016.

11 

Vortmeyer AO, Gläsker S, Lonser RR and Lubensky IA: New insights into the pathogenesis of hemangioblastomas: Cytogenetic and molecular genetic aspects. Neurosurg Rev. 26:243–248. 2003.

12 

Patel J, Rao VY and Lall RR: Innovations in imaging techniques and neurosurgical navigation for brain tumor surgery: Implications for the management of hemangioblastomas. World Neurosurg. 123:292–303. 2019.

13 

Wild-Bode C, Weller M and Wick W: Molecular determinants of glioma cell migration and invasion. J Neurosurg Sci. 45:73–80. 2001.PubMed/NCBI View Article : Google Scholar

14 

Ito E, Ichikawa T and Takahashi T: Advances in the surgical treatment of hemangioblastomas: Current perspectives and future directions. Neurosurg Rev. 34:211–219. 2011.

15 

Vortmeyer AO and Lubensky IA: Molecular biology of von Hippel-Lindau disease. Neurosurg Focus. 19(E2)2005.

16 

Maher ER, Iselius L, Yates JR, Littler M, Benjamin C, Harris R, Sampson J, Williams A, Ferguson-Smith MA and Morton N: Von Hippel-Lindau disease: A genetic study. J Med Genet. 28:443–447. 1991.PubMed/NCBI View Article : Google Scholar

17 

Kaelin WG Jr: Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer. 2:673–682. 2002.PubMed/NCBI View Article : Google Scholar

18 

Huntoon K, Willard S and Boulis N: Advances in the understanding of the molecular pathogenesis of von Hippel-Lindau disease: A review. J Neurosurg. 106:848–859. 2007.

19 

Richard S, Campello C and Taillandier L: Hemangioblastoma of the central nervous system. Neurochirurgie. 47:455–465. 2001.

20 

Conway JE, Chou D, Clatterbuck RE, Brem H, Long DM and Rigamonti D: Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery. 48:55–62. 2001.PubMed/NCBI View Article : Google Scholar

21 

Liao CC and Huang YH: Clinical features and surgical outcomes of sporadic cerebellar hemangioblastomas. Clin Neurol Neurosurg. 125:160–165. 2014.PubMed/NCBI View Article : Google Scholar

22 

Nimbvikar AA, Panchawagh S, Chavan AP, Ingole JR, Pargaonkar Y and Pai R: Modified rankin scale is a reliable tool for the rapid assessment of stroke severity and predicting disability outcomes. J Family Med Prim Care. 13:1085–1090. 2024.PubMed/NCBI View Article : Google Scholar

23 

Kasapas K, Malli A, Sfikas S and Georgakoulias N: Sporadic pituitary stalk hemangioblastoma: A rare case report and review of the literature. Cureus. 12(e9107)2020.PubMed/NCBI View Article : Google Scholar

24 

Kosty J, Staarman B, Zimmer LA and Zuccarello M: Infundibular hemangioblastoma in a patient with neurofibromatosis type 1: Case report and review of the literature. World Neurosurg. 88:693.e697–e693.e612. 2016.PubMed/NCBI View Article : Google Scholar

25 

Fu H, Hao S, Wu Z, Zhang J and Zhang L: Sporadic pituitary stalk hemangioblastoma. Neurol India. 59:937–938. 2011.PubMed/NCBI View Article : Google Scholar

26 

Moscovici S, Candanedo C, Spektor S, Cohen JE and Kaye AH: Solid vs. cystic predominance in posterior fossa hemangioblastomas: Implications for cerebrovascular risks and patient outcome. Acta Neurochir (Wien). 164:1357–1364. 2022.PubMed/NCBI View Article : Google Scholar

27 

Xia H, Li J, Xia Y, Zhong D, Wu X, He D, Shi D, Li J and Sun X: Sporadic solid/cystic hemangioblastomas in the cerebellum: Retrospective study of more than ten years of experience in a single center. World Neurosurg. 144:e908–e915. 2020.PubMed/NCBI View Article : Google Scholar

28 

Jang HJ, Moon BJ, Kim KH, Park JY, Chin DK, Cho YE and Kim KS: Prognostic factors of spinal intramedullary hemangioblastoma: Analysis of surgical outcomes and tumor characteristics. J Korean Neurosurg Soc. 23(10.3340/jkns.2023.0221)2024.PubMed/NCBI View Article : Google Scholar

29 

Kuharic M, Jankovic D, Splavski B, Boop FA and Arnautovic KI: Hemangioblastomas of the posterior cranial fossa in adults: Demographics, clinical, morphologic, pathologic, surgical features, and outcomes. A systematic review. World Neurosurg. 110:e1049–e1062. 2018.PubMed/NCBI View Article : Google Scholar

30 

Lee GJ, Jung TY, Kim IY, Jung S, Jang WY, Moon KS and Kim SK: The clinical experience of recurrent central nervous system hemangioblastomas. Clin Neurol Neurosurg. 123:90–95. 2014.PubMed/NCBI View Article : Google Scholar

31 

Reecher HM, Hussain O, Treffy R and Nerva JD: Preoperative embolization and microsurgical resection of a cerebellar hemangioblastoma: Embolization goals and technical nuances of the approaches. Illustrative case. J Neurosurg Case Lessons. 7(CASE24100)2024.PubMed/NCBI View Article : Google Scholar

32 

Vargas-Urbina J, Crisanto-Silva JA, Vasquez-Perez C, Davila-Adrianzen A, Alcas-Seminario D, Lines-Aguilar W, Mamani-Choquepata R and Panta-Rojas G: Multimodal management of giant solid hemangioblastomas in two patients with preoperative embolization. Surg Neurol Int. 15(144)2024.PubMed/NCBI View Article : Google Scholar

33 

Wang Q, Zhang S, Cheng J, Liu W and Hui X: Radiologic features and surgical strategy of hemangioblastomas with enhanced cyst wall. World Neurosurg. 108:143–150. 2017.PubMed/NCBI View Article : Google Scholar

34 

Vergauwen E, Steiert C, Kruger MT, Jilg C, Zschiedrich S, Klingler JH, Van Velthoven V and Gläsker S: Cumulative surgical morbidity in patients with multiple cerebellar and medullary hemangioblastomas. Clin Neurol Neurosurg. 197(106111)2020.PubMed/NCBI View Article : Google Scholar

35 

Niu L, Zhang Y, Li Q, Dai J, Yin H, Duan L, Yang H, Liang W, Qin Z, Zhang J and Pan Y: The analysis of correlative factors affecting long-term outcomes in patients with solid cerebellar Hemangioblastomas. Clin Neurol Neurosurg. 150:59–66. 2016.PubMed/NCBI View Article : Google Scholar

36 

Wan JQ, Cui H and Wang Y: Surgical management of large solid hemangioblastomas of the posterior fossa. J Clin Neurosci. 18:39–42. 2011.PubMed/NCBI View Article : Google Scholar

37 

Saliou G, Giammattei L, Ozanne A and Messerer M: Role of preoperative embolization of intramedullary hemangioblastoma. Neurochirurgie. 63:372–375. 2017.PubMed/NCBI View Article : Google Scholar

38 

Sakamoto N, Ishikawa E, Nakai Y, Akutsu H, Yamamoto T, Nakai K, Shiigai M, Tsurushima H, Isobe T, Takano S, et al: Preoperative endovascular embolization for hemangioblastoma in the posterior fossa. Neurol Med Chir (Tokyo). 52:878–884. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hao G, Zhang B, Li Y, Wu Y, Han Y and Chen X: Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas. Mol Clin Oncol 21: 83, 2024.
APA
Hao, G., Zhang, B., Li, Y., Wu, Y., Han, Y., & Chen, X. (2024). Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas. Molecular and Clinical Oncology, 21, 83. https://doi.org/10.3892/mco.2024.2781
MLA
Hao, G., Zhang, B., Li, Y., Wu, Y., Han, Y., Chen, X."Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas". Molecular and Clinical Oncology 21.5 (2024): 83.
Chicago
Hao, G., Zhang, B., Li, Y., Wu, Y., Han, Y., Chen, X."Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas". Molecular and Clinical Oncology 21, no. 5 (2024): 83. https://doi.org/10.3892/mco.2024.2781
Copy and paste a formatted citation
x
Spandidos Publications style
Hao G, Zhang B, Li Y, Wu Y, Han Y and Chen X: Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas. Mol Clin Oncol 21: 83, 2024.
APA
Hao, G., Zhang, B., Li, Y., Wu, Y., Han, Y., & Chen, X. (2024). Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas. Molecular and Clinical Oncology, 21, 83. https://doi.org/10.3892/mco.2024.2781
MLA
Hao, G., Zhang, B., Li, Y., Wu, Y., Han, Y., Chen, X."Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas". Molecular and Clinical Oncology 21.5 (2024): 83.
Chicago
Hao, G., Zhang, B., Li, Y., Wu, Y., Han, Y., Chen, X."Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas". Molecular and Clinical Oncology 21, no. 5 (2024): 83. https://doi.org/10.3892/mco.2024.2781
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team