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Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method

  • Authors:
    • Shota Higami
    • Yusuke Tanaka
    • Tomomi Deguchi
    • Mariko Shiraishi
    • Yasuhiko Shiki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka Rosai Hospital, Sakai, Osaka 591‑8025, Japan
    Copyright: © Higami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 84
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    Published online on: September 9, 2024
       https://doi.org/10.3892/mco.2024.2782
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Abstract

The present study aimed to investigate the surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi (S‑T) conization method. A total of 858 cases of high‑grade intraepithelial lesions treated with S‑T conization were retrospectively reviewed, and the surgical, oncological and obstetric outcomes were analyzed. The χ2 test was used to compare the clinical characteristics between patients with and without cervical stenosis. The factors associated with recurrent/persistent disease were analyzed using univariate and multivariate analyses with a Cox hazards regression model. The obstetric outcomes after conization were also evaluated. Cervical stenosis and recurrent/persistent disease occurred in 2.2 and 4.9% of the patients, respectively. Older age [≥45 years; hazard ratio (HR), 3.22; 95% CI, 1.73‑6.02] and surgical margin involvement (HR, 6.39; 95% CI, 3.44‑11.8) were independently associated with recurrent/persistent disease. In particular, older patients with endocervical margin involvement showed a higher rate of recurrence (3‑year recurrence rate, 28.1%). The proportion of patients who experienced cervical stenosis was significantly higher in older patients (0.95 vs. 5.7%; P<0.001). Among the 66 deliveries after conization, term delivery was observed in 62 cases (93.9%). The proportion of patients who experienced preterm delivery after conization was significantly higher in patients with a short interval from conization to conception (P=0.045). In conclusion, the S‑T conization method was effective in terms of surgical, oncological and obstetric outcomes. A careful follow‑up is required for older patients with positive surgical margins, particularly those with positive endocervical margins. In addition, a short interval of ≤3 months from conization to conception should be avoided to expect term pregnancy.
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1 

Ostör AG: Natural history of cervical intraepithelial neoplasia: A critical review. Int J Gynecol Pathol. 12:186–192. 1993.PubMed/NCBI

2 

Santesso N, Mustafa RA, Wiercioch W, Kehar R, Gandhi S, Chen Y, Cheung A, Hopkins J, Khatib R, Ma B, et al: Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia. Int J Gynaecol Obstet. 132:266–271. 2016.PubMed/NCBI View Article : Google Scholar

3 

Tanaka Y, Ueda Y, Kakuda M, Kubota S, Matsuzaki S, Iwamiya T, Okazawa A, Matsuzaki S, Hashimoto K, Kobayashi E, et al: Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: A retrospective analysis of 522 cases. Int J Clin Oncol. 22:921–926. 2017.PubMed/NCBI View Article : Google Scholar

4 

Ikeda M, Mikami M, Yasaka M, Enomoto T, Kobayashi Y, Nagase S, Yokoyama M and Katabuchi H: Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: A retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology. J Gynecol Oncol. 32(e68)2021.PubMed/NCBI View Article : Google Scholar

5 

Matsumura M, Ota T, Takeshima N and Takizawa K: Shimodaira-Taniguchi conization method: Its utility and reliability. Int J Gynecol Cancer. 20:1025–1030. 2010.PubMed/NCBI View Article : Google Scholar

6 

Miyoshi Y, Miyatake T, Ueda Y, Morimoto A, Yokoyama T, Matsuzaki S, Kimura T, Yoshino K, Fujita M, Ohashi H, et al: Prediction, based on resection margins, of long-term outcome of cervical intraepithelial neoplasia 3 treated by Shimodaira-Taniguchi conization. Arch Gynecol Obstet. 285:1427–1432. 2012.PubMed/NCBI View Article : Google Scholar

7 

Kigure K, Nakamura K, Kitahara Y, Nakao K, Hirakawa T, Rokukawa S, Ito M, Nishimura T, Ito I, Kagami I and Itoga S: An electrical scalpel conization versus Shimodaira-Taniguchi conization procedure for cervical intraepithelial neoplasia. Medicine (Baltimore). 97(e12640)2018.PubMed/NCBI View Article : Google Scholar

8 

Kirkwood BR and Sterne JAC: Essential medical statistics. 2nd edition. Blackwell, Oxford, pp168-169, 2003.

9 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013.PubMed/NCBI View Article : Google Scholar

10 

Kobayashi Y: Conization. Comprehensive Gynecology and Obstetrics. In: Surgery for Gynecologic Cancer. Mikami M (ed). Springer, pp43-54, 2019.

11 

Hasegawa K, Torii Y, Kato R, Udagawa Y and Fukasawa I: The problems of cervical conization for postmenopausal patients. Eur J Gynaecol Oncol. 37:327–331. 2016.PubMed/NCBI

12 

Bae HS, Chung YW, Kim T, Lee KW and Song JY: The appropriate cone depth to avoid endocervical margin involvement is dependent on age and disease severity. Acta Obstet Gynecol Scand. 92:185–192. 2013.PubMed/NCBI View Article : Google Scholar

13 

Bogani G, DI Donato V, Sopracordevole F, Ciavattini A, Ghelardi A, Lopez S, Simoncini T, Plotti F, Casarin J, Serati M, et al: Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study. Gynecol Oncol. 159:636–641. 2020.PubMed/NCBI View Article : Google Scholar

14 

Reich O, Pickel H, Lahousen M, Tamussino K and Winter R: Cervical intraepithelial neoplasia III: Long-term outcome after cold-knife conization with clear margins. Obstet Gynecol. 97:428–430. 2001.PubMed/NCBI View Article : Google Scholar

15 

Reich O, Lahousen M, Pickel H, Tamussino K and Winter R: Cervical intraepithelial neoplasia III: Long-term follow-up after cold-knife conization with involved margins. Obstet Gynecol. 99:193–196. 2002.PubMed/NCBI View Article : Google Scholar

16 

Ministry of Health, Labor and Welfare of Japan: Vital Statistics of Japan, 2019. https://www.mhlw.go.jp/english/database/db-hw/dl/81-1a2en.pdf. Accessed January 22, 2023.

17 

Sasieni P, Castanon A, Landy R, Kyrgiou M, Kitchener H, Quigley M, Poon L, Shennan A, Hollingworth A, Soutter WP, et al: Risk of preterm birth following surgical treatment for cervical disease: Executive summary of a recent symposium. BJOG. 123:1426–1429. 2016.PubMed/NCBI View Article : Google Scholar

18 

Himes KP and Simhan HN: Time from cervical conization to pregnancy and preterm birth. Obstet Gynecol. 109 (2 Pt 1):314–319. 2007.PubMed/NCBI View Article : Google Scholar

19 

Heinonen A, Gissler M, Riska A, Paavonen J, Tapper AM and Jakobsson M: Loop electrosurgical excision procedure and the risk for preterm delivery. Obstet Gynecol. 121:1063–1068. 2013.PubMed/NCBI View Article : Google Scholar

20 

Conner SN, Cahill AG, Tuuli MG, Stamilio DM, Odibo AO, Roehl KA and Macones GA: Interval from loop electrosurgical excision procedure to pregnancy and pregnancy outcomes. Obstet Gynecol. 122:1154–1159. 2013.PubMed/NCBI View Article : Google Scholar

21 

Noehr B, Jensen A, Frederiksen K, Tabor A and Kjaer SK: Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery. Obstet Gynecol. 114:1232–1238. 2009.PubMed/NCBI View Article : Google Scholar

22 

Bevis KS and Biggio JR: Cervical conization and the risk of preterm delivery. Am J Obstet Gynecol. 205:19–27. 2011.PubMed/NCBI View Article : Google Scholar

23 

Kyrgiou M, Valasoulis G, Stasinou SM, Founta C, Athanasiou A, Bennett P and Paraskevadis E: Proportion of cervical excision for cervical intraepithelial neoplasia as a predictor of pregnancy outcomes. Int J Gynaecol Obstet. 128:141–147. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Higami S, Tanaka Y, Deguchi T, Shiraishi M and Shiki Y: Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method. Mol Clin Oncol 21: 84, 2024.
APA
Higami, S., Tanaka, Y., Deguchi, T., Shiraishi, M., & Shiki, Y. (2024). Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method. Molecular and Clinical Oncology, 21, 84. https://doi.org/10.3892/mco.2024.2782
MLA
Higami, S., Tanaka, Y., Deguchi, T., Shiraishi, M., Shiki, Y."Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method". Molecular and Clinical Oncology 21.5 (2024): 84.
Chicago
Higami, S., Tanaka, Y., Deguchi, T., Shiraishi, M., Shiki, Y."Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method". Molecular and Clinical Oncology 21, no. 5 (2024): 84. https://doi.org/10.3892/mco.2024.2782
Copy and paste a formatted citation
x
Spandidos Publications style
Higami S, Tanaka Y, Deguchi T, Shiraishi M and Shiki Y: Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method. Mol Clin Oncol 21: 84, 2024.
APA
Higami, S., Tanaka, Y., Deguchi, T., Shiraishi, M., & Shiki, Y. (2024). Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method. Molecular and Clinical Oncology, 21, 84. https://doi.org/10.3892/mco.2024.2782
MLA
Higami, S., Tanaka, Y., Deguchi, T., Shiraishi, M., Shiki, Y."Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method". Molecular and Clinical Oncology 21.5 (2024): 84.
Chicago
Higami, S., Tanaka, Y., Deguchi, T., Shiraishi, M., Shiki, Y."Surgical, oncological and obstetric outcomes of the Shimodaira-Taniguchi conization method". Molecular and Clinical Oncology 21, no. 5 (2024): 84. https://doi.org/10.3892/mco.2024.2782
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