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Article Open Access

Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy

  • Authors:
    • Yi-Chia Hsieh
    • Ian Seng Cheong
    • Lin-Nei Hsu
    • Hsin-Tzu Tsai
    • Tzong-Shin Tzai
    • Yeong-Chin Jou
    • Yuh-Shyan Tsai
  • View Affiliations / Copyright

    Affiliations: Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan, R.O.C., Department of Urology, Ditmanson Medical Foundation Chia‑Yi Christian Hospital, Chiayi 600566, Taiwan, R.O.C., Department of Urology, An Nan Hospital, China Medical University, Tainan 709204, Taiwan, R.O.C., Division of Urology, Department of Surgery, St Martin De Porres Hospital, Chiayi 600044, Taiwan, R.O.C.
    Copyright: © Hsieh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 86
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    Published online on: September 16, 2024
       https://doi.org/10.3892/mco.2024.2784
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Abstract

Urinary 8‑hydroxydeoxyguanosine (8‑OHdG) level is an oxidative stress marker in patients with cancer; however, little is currently known about the clinical relevance of urinary 8‑OHdG levels in patients with prostate cancer at diagnosis. Voided urine samples were collected from patients at the time of prostate biopsy and stored at ‑80˚C after centrifugation. All of the patients were classified according to histology of the biopsy. Once the patients were diagnosed with prostate cancer, the standard of care and treatments were administered according to the standard guidelines. The association between clinicopathological parameters and urinary 8‑OHdG and N‑terminal telopeptide (NTx) levels were explored. A total of 409 patients received prostate biopsy, of which 190 were benign, 41 were diagnosed with prostatitis and 178 were diagnosed with prostate cancer. The urinary 8‑OHdG/creatinine ratio was marginally associated with prostate size (P=0.052) but not with serum prostate‑specific antigen levels (P=0.707). With correction for prostate size, the ratio of urinary 8‑OHdG/creatinine was significantly higher in patients with prostate cancer than those without malignancy (P=0.004). Moreover, urinary 8‑OHdG levels were weakly associated with urinary NTx levels (r2=0.04, P=0.009). In conclusion, urinary 8‑OHdG levels normalized for prostate volume may reflect prostate cancer risk and could be used to predict prostate cancer aggressiveness.
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Copy and paste a formatted citation
Spandidos Publications style
Hsieh Y, Cheong IS, Hsu L, Tsai H, Tzai T, Jou Y and Tsai Y: Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy. Mol Clin Oncol 21: 86, 2024.
APA
Hsieh, Y., Cheong, I.S., Hsu, L., Tsai, H., Tzai, T., Jou, Y., & Tsai, Y. (2024). Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy. Molecular and Clinical Oncology, 21, 86. https://doi.org/10.3892/mco.2024.2784
MLA
Hsieh, Y., Cheong, I. S., Hsu, L., Tsai, H., Tzai, T., Jou, Y., Tsai, Y."Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy". Molecular and Clinical Oncology 21.5 (2024): 86.
Chicago
Hsieh, Y., Cheong, I. S., Hsu, L., Tsai, H., Tzai, T., Jou, Y., Tsai, Y."Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy". Molecular and Clinical Oncology 21, no. 5 (2024): 86. https://doi.org/10.3892/mco.2024.2784
Copy and paste a formatted citation
x
Spandidos Publications style
Hsieh Y, Cheong IS, Hsu L, Tsai H, Tzai T, Jou Y and Tsai Y: Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy. Mol Clin Oncol 21: 86, 2024.
APA
Hsieh, Y., Cheong, I.S., Hsu, L., Tsai, H., Tzai, T., Jou, Y., & Tsai, Y. (2024). Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy. Molecular and Clinical Oncology, 21, 86. https://doi.org/10.3892/mco.2024.2784
MLA
Hsieh, Y., Cheong, I. S., Hsu, L., Tsai, H., Tzai, T., Jou, Y., Tsai, Y."Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy". Molecular and Clinical Oncology 21.5 (2024): 86.
Chicago
Hsieh, Y., Cheong, I. S., Hsu, L., Tsai, H., Tzai, T., Jou, Y., Tsai, Y."Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy". Molecular and Clinical Oncology 21, no. 5 (2024): 86. https://doi.org/10.3892/mco.2024.2784
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