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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2024 Volume 21 Issue 6

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Case Report Open Access

Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report

  • Authors:
    • Marlies Maly
    • Lieve Vanwalleghem
    • Anja Van Den Eeckhaut
    • Vincent De Wilde
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Ghent University Hospital, 9000 Ghent, Belgium, Department of Pathology, AZ Sint‑Jan, 8000 Bruges, Belgium, Department of Nuclear Medicine, AZ Sint‑Jan, 8000 Bruges, Belgium, Department of Gastroenterology and Hepatology, AZ Sint‑Jan, 8000 Bruges, Belgium
    Copyright: © Maly et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 88
    |
    Published online on: September 30, 2024
       https://doi.org/10.3892/mco.2024.2786
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Abstract

The diagnostic work‑up of cancer of unknown primary (CUP) is a challenging task; in addition, only a little data on BRAF targeting in CUP are currently available. Traditionally, the identification of favourable and unfavourable CUP subsets directs the choice of treatment. The present article reports the case of a 50‑year‑old male patient presenting with a BRAF‑mutated CUP, a rare and generally unfavourable subset. Based on imaging, immunohistochemistry and a high value of carbohydrate antigen 19‑9, an upper gastrointestinal profile was initially presumed. After disease progression on treatment with a first‑line platinum‑based doublet chemotherapy, a significant response was documented after treatment with the BEACON combination. The present case report highlighted the paradigm shift in diagnosis and treatment of CUP from a histology‑based approach to molecular profiling with the introduction of precision medicine.
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Copy and paste a formatted citation
Spandidos Publications style
Maly M, Vanwalleghem L, Van Den Eeckhaut A and De Wilde V: Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report. Mol Clin Oncol 21: 88, 2024.
APA
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., & De Wilde, V. (2024). Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report. Molecular and Clinical Oncology, 21, 88. https://doi.org/10.3892/mco.2024.2786
MLA
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., De Wilde, V."Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report". Molecular and Clinical Oncology 21.6 (2024): 88.
Chicago
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., De Wilde, V."Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report". Molecular and Clinical Oncology 21, no. 6 (2024): 88. https://doi.org/10.3892/mco.2024.2786
Copy and paste a formatted citation
x
Spandidos Publications style
Maly M, Vanwalleghem L, Van Den Eeckhaut A and De Wilde V: Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report. Mol Clin Oncol 21: 88, 2024.
APA
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., & De Wilde, V. (2024). Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report. Molecular and Clinical Oncology, 21, 88. https://doi.org/10.3892/mco.2024.2786
MLA
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., De Wilde, V."Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report". Molecular and Clinical Oncology 21.6 (2024): 88.
Chicago
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., De Wilde, V."Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report". Molecular and Clinical Oncology 21, no. 6 (2024): 88. https://doi.org/10.3892/mco.2024.2786
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