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Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature

  • Authors:
    • Yongmei Wang
    • Xueqing Zou
    • Yan Mao
    • Meng Lv
    • Wenfeng Li
  • View Affiliations / Copyright

    Affiliations: Breast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 92
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    Published online on: October 10, 2024
       https://doi.org/10.3892/mco.2024.2790
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Abstract

Combined chemotherapy is typically the preferred treatment for patients with hormone receptor‑positive (HR+)/human epidermal growth factor receptor 2‑negative (HER2‑) metastatic breast cancer (MBC) experiencing a visceral crisis. However, the emergence of cyclin‑dependent kinase 4/6 inhibitors (CDK4/6i) has introduced a potential alternative: The combination of CDK4/6i with endocrine therapy (ET). The present study reported a case of HR+/HER2‑MBC with extensive liver and bone metastases who responded well to abemaciclib and letrozole. The patient achieved a rapid partial response and continuous clinical stabilization and the progression‑free survival of this patient reaches 30 months and counting. Furthermore, the side effects were manageable and no dose reductions were necessary during treatment. These findings suggest that the combination of CDK4/6i and ET in the treatment of HR+/HER2‑advanced breast cancer cannot be underestimated.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zou X, Mao Y, Lv M and Li W: Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature. Mol Clin Oncol 21: 92, 2024.
APA
Wang, Y., Zou, X., Mao, Y., Lv, M., & Li, W. (2024). Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature. Molecular and Clinical Oncology, 21, 92. https://doi.org/10.3892/mco.2024.2790
MLA
Wang, Y., Zou, X., Mao, Y., Lv, M., Li, W."Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature". Molecular and Clinical Oncology 21.6 (2024): 92.
Chicago
Wang, Y., Zou, X., Mao, Y., Lv, M., Li, W."Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature". Molecular and Clinical Oncology 21, no. 6 (2024): 92. https://doi.org/10.3892/mco.2024.2790
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zou X, Mao Y, Lv M and Li W: Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature. Mol Clin Oncol 21: 92, 2024.
APA
Wang, Y., Zou, X., Mao, Y., Lv, M., & Li, W. (2024). Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature. Molecular and Clinical Oncology, 21, 92. https://doi.org/10.3892/mco.2024.2790
MLA
Wang, Y., Zou, X., Mao, Y., Lv, M., Li, W."Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature". Molecular and Clinical Oncology 21.6 (2024): 92.
Chicago
Wang, Y., Zou, X., Mao, Y., Lv, M., Li, W."Patient with hormone receptor‑positive Her2‑negative metastatic breast cancer with visceral crisis with good response to abemaciclib and letrozole: A case report and review of the literature". Molecular and Clinical Oncology 21, no. 6 (2024): 92. https://doi.org/10.3892/mco.2024.2790
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