Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
December-2024 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures

  • Authors:
    • Xiangji Li
    • Chunlei Tian
    • Junlan Yao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Yichang Central People's Hospital, Yichang, Hubei 443003, P.R. China, Department of Pediatrics, Yichang Central People's Hospital, Yichang, Hubei 443003, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
    |
    Published online on: October 18, 2024
       https://doi.org/10.3892/mco.2024.2792
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pathologies of pediatric pituitary adenomas are uncommon and challenging to diagnose. Pituitary adenomas cause mass effects and neurological disruption in children. Postoperative evaluations of endocrine functions are challenging. The present study categorized adenomas by size and type, and evaluated outcomes based on the surgical procedures adopted. In addition, the present study analyzed the demographic parameters of children as well as the factors supposed to be influencing remission. Clinical characteristics, treatment parameters and postoperative outcomes of curative surgeries in 135 children [80 (59%) females and 55 (41%) males; age 12 (11‑13) years at the time of first diagnosis] with pituitary adenomas who underwent curative surgeries operated between 1998 and 2023 in the Yichang Central People's Hospital, (Yichang, China) were included in the present retrospective study. A total of 112 (83%) children had microadenomas (<10 mm adenomas), 6 (4%) had macroadenomas (≥10 mm adenomas) and 17 (13%) had invisible adenomas. Pathological examination revealed that 59 (44%) children had functional adenomas and 10 (7%) had non‑functional adenomas. Among functional adenomas, acromegaly (excess secretion of insulin‑like growth factor 1) was reported to be the most common [30 (22%)] pediatric adenomas, followed by prolactinomas [prolactin secretion ≥1,000 mIU/l; 20 (15%) and Cushing syndrome (9 (7%)]. A total of 23 (17%), 3 (2%), 4 (3%), 3 (2%) and 3 (2%) children were reported to have remission and underwent re‑surgery. These patients (remission) underwent microscopic trans‑sphenoidal resection, endoscopic endonasal trans‑sphenoidal resection, trans‑sphenoidal resection alone, bilateral adrenalectomy and gross total resection adopted curative surgeries initially, respectively. Postoperative diabetes insipidus, adrenal insufficiency and cerebrospinal fluid leaks have been reported in children who have undergone curative surgeries for macroadenomas or Cushing syndrome. Female pediatric patients with clinical manifestations were more likely to have pituitary adenomas. Pediatric patients generally have functional pituitary adenomas, particularly adreno‑corticotropin‑secreting adenomas. Microscopic trans‑sphenoidal resection is associated with a lower risk of under‑treatment. Postoperative outcomes and clinical benefits of curative surgeries are based on the complete type of surgical removal and size of the pituitary adenomas mass (Level of Evidence: 3; Technical Efficacy Stage: 4).
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kilci F, Jones JH, Çaklılı M, Ceylan S and Çizmecioğlu-Jones FM: Clinical and therapeutic outcomes of pediatric pituitary adenomas: A single pituitary center experience. Endocrine. 83:160–170. 2024.PubMed/NCBI View Article : Google Scholar

2 

Locatelli D, Veiceschi P, Castelnuovo P, Tanriover N, Evliyaoglu O, Canaz H, Ugurlar D and Gazioglu N: Transsphenoidal surgery for pituitary adenomas in pediatric patients: A multicentric retrospective study. Childs Nerv Syst. 35:2119–2126. 2019.PubMed/NCBI View Article : Google Scholar

3 

Beckers A, Aaltonen LA, Daly AF and Karhu A: Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. Endocr Rev. 34:239–277. 2013.PubMed/NCBI View Article : Google Scholar

4 

Guaraldi F, Storr HL, Ghizzoni L, Ghigo E and Savage MO: Paediatric pituitary adenomas: A decade of change. Horm Res Paediatr. 81:145–155. 2014.PubMed/NCBI View Article : Google Scholar

5 

Kelly AP, Greenfield JP, Dobri GA and Schwartz TH: Pediatric pituitary adenomas are more aggressive, more likely to be hormone producing and are more difficult to cure than adult pituitary adenomas: Case series and systematic literature review. Childs Nerv Syst. 38:729–738. 2022.PubMed/NCBI View Article : Google Scholar

6 

Li X, Deng K, Zhang Y, Feng M, Xing B, Lian W and Yao Y: Pediatric pituitary neuroendocrine tumors-a 13-year experience in a tertiary center. Front Oncol. 13(1270958)2023.PubMed/NCBI View Article : Google Scholar

7 

Perry A, Graffeo CS, Marcellino C, Pollock BE, Wetjen NM and Meyer FB: Pediatric pituitary adenoma: Case series, review of the literature, and a skull base treatment paradigm. J Neurol Surg B Skull Base. 79:91–114. 2018.PubMed/NCBI View Article : Google Scholar

8 

Jahangiri A, Wagner JR, Han SW, Tran MT, Miller LM, Chen R, Tom MW, Ostling LR, Kunwar S, Blevins L and Aghi MK: Improved versus worsened endocrine function after transsphenoidal surgery for nonfunctional pituitary adenomas: Rate, time course, and radiological analysis. J Neurosurg. 124:589–595. 2016.PubMed/NCBI View Article : Google Scholar

9 

Zhang Y, Yu D, Yang Q and Li W: Diagnostic efficacy of physical examination, preoperative ultrasound, and/or computed tomography in detecting lymph node metastasis: A single-center retrospective analysis of patients with squamous cell carcinoma of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol. 134:386–396. 2022.PubMed/NCBI View Article : Google Scholar

10 

Chen L, Cheng Y, Zhou L, Zhang L and Deng X: Quantitative shear wave elastography compared to standard ultrasound (qualitative B-mode grayscale sonography and quantitative power Doppler) for evaluation of achillotendinopathy in treatment-naïve individuals: A cross-sectional study. Adv Clin Exp Med. 31:847–854. 2022.PubMed/NCBI View Article : Google Scholar

11 

Hwang YC, Chung JH, Min YK, Lee MS, Lee MK and Kim KW: Comparisons between macroadenomas and microadenomas in Cushing's disease: Characteristics of hormone secretion and clinical outcomes. J Korean Med Sci. 24:46–51. 2009.PubMed/NCBI View Article : Google Scholar

12 

Ershadinia N and Tritos NA: Diagnosis and treatment of acromegaly: An update. Mayo Clin Proc. 97:333–346. 2022.PubMed/NCBI View Article : Google Scholar

13 

Inder WJ and Jang C: Treatment of prolactinoma. Medicina (Kaunas). 58(1095)2022.PubMed/NCBI View Article : Google Scholar

14 

Chen J, Schmidt RE and Dahiya S: Pituitary adenoma in pediatric and adolescent populations. J Neuropathol Exp Neurol. 78:626–632. 2019.PubMed/NCBI View Article : Google Scholar

15 

Castellanos LE, Misra M, Smith TR, Laws ER and Iorgulescu JB: The epidemiology and management patterns of pediatric pituitary tumors in the United States. Pituitary. 24:412–419. 2021.PubMed/NCBI View Article : Google Scholar

16 

Shlomo M, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA and Wass JA: Endocrine Society. Diagnosis and treatment of hyperprolactinemia: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 96:273–288. 2011.PubMed/NCBI View Article : Google Scholar

17 

Jackman S and Diamond F: Pituitary adenomas in childhood and adolescence. Pediatr Endocrinol Rev. 10:450–459. 2013.PubMed/NCBI

18 

Ho KKY, Kaiser UB, Chanson P, Gadelha M, Wass J, Nieman L, Little A, Aghi MK, Raetzman L, Post K, et al: Pituitary adenoma or neuroendocrine tumour: The need for an integrated prognostic classification. Nat Rev Endocrinol. 19:671–678. 2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Tian C and Yao J: Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures. Mol Clin Oncol 21: 94, 2024.
APA
Li, X., Tian, C., & Yao, J. (2024). Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures. Molecular and Clinical Oncology, 21, 94. https://doi.org/10.3892/mco.2024.2792
MLA
Li, X., Tian, C., Yao, J."Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures". Molecular and Clinical Oncology 21.6 (2024): 94.
Chicago
Li, X., Tian, C., Yao, J."Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures". Molecular and Clinical Oncology 21, no. 6 (2024): 94. https://doi.org/10.3892/mco.2024.2792
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Tian C and Yao J: Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures. Mol Clin Oncol 21: 94, 2024.
APA
Li, X., Tian, C., & Yao, J. (2024). Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures. Molecular and Clinical Oncology, 21, 94. https://doi.org/10.3892/mco.2024.2792
MLA
Li, X., Tian, C., Yao, J."Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures". Molecular and Clinical Oncology 21.6 (2024): 94.
Chicago
Li, X., Tian, C., Yao, J."Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures". Molecular and Clinical Oncology 21, no. 6 (2024): 94. https://doi.org/10.3892/mco.2024.2792
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team