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Incidence of myelosuppression in AML is higher compared with that in ALL

  • Authors:
    • Wanling Chen
    • Hongtao Wang
    • Jiasheng Hu
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    Affiliations: Department of Clinical Medicine, Xiamen Medical College, Xiamen, Fujian 361023, P.R. China, Department of Hematology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian 361004, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 95
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    Published online on: October 18, 2024
       https://doi.org/10.3892/mco.2024.2793
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Abstract

Acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) are two subtypes of acute leukemia. However, studies investigating the ability of complete blood count (CBC) parameters to distinguish between patients with AML and ALL remain scarce in the literature. The objective of the present study was to compare the parameters of CBC analysis between Chinese patients with AML and ALL and between patients with M3 AML and non‑M3 AML. Prognostic factors for overall survival were also estimated, including sex, age, white blood cell count and hemoglobin. The present study included 147 patients, including children and adults, with newly diagnosed acute leukemia. Information on the age, sex, leukemia subtype, initial CBC results and clinical follow‑up findings was recorded and compared between the indicated groups using statistical tests of Mann‑Whitney U test and χ2 test. Leukopenia (white blood cell count <3.5x109/l), both leukopenia and anemia, both leukopenia and thrombocytopenia and pancytopenia were found to be significantly more frequent among patients with AML compared with that in patients with ALL (P=0.015, 0.016, 0.015 and 0.019, respectively). For patients with ALL, anemia was recognized as a predictor of a favorable outcome (Hazard ratio, 0.185; 95% CI, 0.046‑0.747; P=0.018). These findings suggest that normal hematopoiesis is more frequently inhibited in patients with AML compared with that in patients with ALL. Patients with AL with peripheral blood findings indicative of leukopenia, pancytopenia, or both leukopenia and anemia or both leukopenia and thrombocytopenia are more likely to have AML.
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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Wang H and Hu J: Incidence of myelosuppression in AML is higher compared with that in ALL. Mol Clin Oncol 21: 95, 2024.
APA
Chen, W., Wang, H., & Hu, J. (2024). Incidence of myelosuppression in AML is higher compared with that in ALL. Molecular and Clinical Oncology, 21, 95. https://doi.org/10.3892/mco.2024.2793
MLA
Chen, W., Wang, H., Hu, J."Incidence of myelosuppression in AML is higher compared with that in ALL". Molecular and Clinical Oncology 21.6 (2024): 95.
Chicago
Chen, W., Wang, H., Hu, J."Incidence of myelosuppression in AML is higher compared with that in ALL". Molecular and Clinical Oncology 21, no. 6 (2024): 95. https://doi.org/10.3892/mco.2024.2793
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Wang H and Hu J: Incidence of myelosuppression in AML is higher compared with that in ALL. Mol Clin Oncol 21: 95, 2024.
APA
Chen, W., Wang, H., & Hu, J. (2024). Incidence of myelosuppression in AML is higher compared with that in ALL. Molecular and Clinical Oncology, 21, 95. https://doi.org/10.3892/mco.2024.2793
MLA
Chen, W., Wang, H., Hu, J."Incidence of myelosuppression in AML is higher compared with that in ALL". Molecular and Clinical Oncology 21.6 (2024): 95.
Chicago
Chen, W., Wang, H., Hu, J."Incidence of myelosuppression in AML is higher compared with that in ALL". Molecular and Clinical Oncology 21, no. 6 (2024): 95. https://doi.org/10.3892/mco.2024.2793
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