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Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive 125I particles

  • Authors:
    • Tingting Ding
    • Shanhu Hao
    • Zhiguo Wang
    • Wenwen Zhang
    • Guoxu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
    |
    Published online on: October 25, 2024
       https://doi.org/10.3892/mco.2024.2797
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Abstract

The most common and potentially fatal side effect of postoperative radiotherapy using radioactive 125I particles in the chest is radiation‑induced pneumonia (RP). The present study aimed to develop a nomogram to accurately predict RP in patients with lung cancer following this type of radiotherapy. A retrospective analysis was conducted on data from 436 patients with advanced lung cancer who underwent close‑range radiotherapy using radioactive 125I particles at the General Hospital of Northern Theater Command from January 2016 to December 2023 (Shenyang, China). Risk factors for RP were identified through least absolute shrinkage and selection operator logistic regression and multivariable logistic regression analysis. These factors were then used to construct a dynamic nomogram. The predictive performance of the nomogram was validated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis. Additionally, the grading of RP and Kaplan‑Meier analysis were performed. Preoperative N and M staging, the maximum dose and whether chemotherapy was administered were identified as significant predictors of RP. A dynamic nomogram for predicting RP was developed based on these risk factors. The area under the ROC curve was 0.878 (95% CI, 0.814‑0.942) for the training cohort and 0.828 (95% CI, 0.787‑0.870) for the validation cohort, indicating favorable discriminatory ability. The nomogram demonstrated excellent calibration. In both cohorts, the maximum dose parameter provided the most significant clinical benefits, supporting its promising clinical utility. Patients staged as T1 and T3 preoperatively were more likely to develop RP compared with those staged as T2 (P<0.001). Likewise, patients staged as M1 preoperatively, those receiving a maximum dose above the mean, and those who had undergone chemotherapy exhibited a higher probability of developing RP (P<0.001). The developed nomogram offers a precise and user‑friendly tool for clinical application in predicting the risk of RP in patients with lung cancer undergoing close‑range radiotherapy with radioactive 125I particles.
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Copy and paste a formatted citation
Spandidos Publications style
Ding T, Hao S, Wang Z, Zhang W and Zhang G: Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles. Mol Clin Oncol 22: 2, 2025.
APA
Ding, T., Hao, S., Wang, Z., Zhang, W., & Zhang, G. (2025). Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles. Molecular and Clinical Oncology, 22, 2. https://doi.org/10.3892/mco.2024.2797
MLA
Ding, T., Hao, S., Wang, Z., Zhang, W., Zhang, G."Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles". Molecular and Clinical Oncology 22.1 (2025): 2.
Chicago
Ding, T., Hao, S., Wang, Z., Zhang, W., Zhang, G."Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles". Molecular and Clinical Oncology 22, no. 1 (2025): 2. https://doi.org/10.3892/mco.2024.2797
Copy and paste a formatted citation
x
Spandidos Publications style
Ding T, Hao S, Wang Z, Zhang W and Zhang G: Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles. Mol Clin Oncol 22: 2, 2025.
APA
Ding, T., Hao, S., Wang, Z., Zhang, W., & Zhang, G. (2025). Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles. Molecular and Clinical Oncology, 22, 2. https://doi.org/10.3892/mco.2024.2797
MLA
Ding, T., Hao, S., Wang, Z., Zhang, W., Zhang, G."Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles". Molecular and Clinical Oncology 22.1 (2025): 2.
Chicago
Ding, T., Hao, S., Wang, Z., Zhang, W., Zhang, G."Development of a nomogram for predicting radiation‑induced pneumonia in patients with lung cancer undergoing close‑range radiotherapy with radioactive <sup>125</sup>I particles". Molecular and Clinical Oncology 22, no. 1 (2025): 2. https://doi.org/10.3892/mco.2024.2797
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