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Review Open Access

New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)

  • Authors:
    • Krupa R. Bhaliya
    • Muneera Anwer
    • Alan Munn
    • Ming Q. Wei
  • View Affiliations / Copyright

    Affiliations: Menzies Health Institute, School of Medical Science, Griffith University, Southport, Queensland 4215, Australia
    Copyright: © Bhaliya et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 4
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    Published online on: October 31, 2024
       https://doi.org/10.3892/mco.2024.2799
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Abstract

Therapeutic approaches that increase the efficacy and safety of cancer treatments and improve disease outcomes have been developed worldwide. Immunotherapy uses the body's immune system to inhibit cancerous growth in tissues and organs. Various approaches have been developed to effectively control and inhibit cancerous growth, including checkpoint inhibitors, T‑cell transfer therapy, monoclonal antibodies, vaccines and immunomodulators. Toll‑like receptors (TLRs) target malignant cells by equipping the immune response. In addition, TLR agonists serve a key role in promoting the innate immune system and initiating antigen‑specific T‑cell responses. Notably, TLRs and TLR agonists have been utilized as monotherapies or in combination for the treatment of cancer. The present study aimed to review the use of R848 and R837 as TLR agonists, and outline their use as key immunomodulators in cancer therapy.
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1 

Zhang Y and Zhang Z: The history and advances in cancer immunotherapy: Understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol. 17:807–821. 2020.PubMed/NCBI View Article : Google Scholar

2 

Pahlavanneshan S, Sayadmanesh A, Ebrahimiyan H and Basiri M: Toll-like receptor-based strategies for cancer immunotherapy. J Immunol Res. 2021(9912188)2021.PubMed/NCBI View Article : Google Scholar

3 

Chen X, Zhang Y and Fu Y: The critical role of Toll-like receptor-mediated signaling in cancer immunotherapy. Med Drug Disc. 14(100122)2022.

4 

Spyvee M, Hawkins LD and Ishizaka ST: Chapter 12 - Modulators of Toll-Like Receptor (TLR) Signaling. In: Annual Reports in Medicinal Chemistry. Vol 45. Academic Press, pp191-207, 2010.

5 

Ryu KA, Stutts L, Tom JK, Mancini RJ and Esser-Kahn AP: Stimulation of innate immune cells by light-activated TLR7/8 agonists. J Am Chem Soc. 136:10823–10825. 2014.PubMed/NCBI View Article : Google Scholar

6 

Bhagchandani S, Johnson JA and Irvine DJ: Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants. Adv Drug Deliv Rev. 175(113803)2021.PubMed/NCBI View Article : Google Scholar

7 

Tie Y, Tang F, Wei YQ and Wei XW: Immunosuppressive cells in cancer: Mechanisms and potential therapeutic targets. J Hematol Oncol. 15(61)2022.PubMed/NCBI View Article : Google Scholar

8 

Ye J, Mills BN, Qin SS, Garrett-Larsen J, Murphy JD, Uccello TP, Han BJ, Vrooman TG, Johnston CJ, Lord EM, Belt BA, et al: Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. J Immunother Cancer. 10(e004784)2022.PubMed/NCBI View Article : Google Scholar

9 

Mottas I, Bekdemir A, Cereghetti A, Spagnuolo L, Yang YS, Müller M, Irvine DJ, Stellacci F and Bourquin C: Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation. Biomaterials. 190:111–120. 2019.PubMed/NCBI View Article : Google Scholar

10 

Wang DR, Wu XL and Sun YL: Therapeutic targets and biomarkers of tumor immunotherapy: Response versus non-response. Sig Transduct Target Ther. 7(331)2022.PubMed/NCBI View Article : Google Scholar

11 

Leśniak M, Lipniarska J, Majka P, Kopyt W, Lejman M and Zawitkowska J: The Role of TRL7/8 agonists in cancer therapy, with special emphasis on hematologic malignancies. Vaccines (Basel). 11(277)2023.PubMed/NCBI View Article : Google Scholar

12 

Sun H, Li Y, Zhang P, Xing H, Zhao S, Song Y, Wan D and Yu J: Targeting toll-like receptor 7/8 for immunotherapy: Recent advances and prospectives. Biomark Res. 10(89)2022.PubMed/NCBI View Article : Google Scholar

13 

Karnik I, Her Z, Neo SH, Liu WN and Chen Q: Emerging preclinical applications of humanized mouse models in the discovery and validation of novel immunotherapeutics and their mechanisms of action for improved cancer treatment. Pharmaceutics. 15(1600)2023.PubMed/NCBI View Article : Google Scholar

14 

Deza G, Martin-Ezquerra G, Curto-Barredo L, García JV and Pujol RM: Successful treatment of hypertrophic herpes simplex genitalis in an HIV-infected patient with topical Imiquimod. J Dermatol. 42:1176–1178. 2015.PubMed/NCBI View Article : Google Scholar

15 

Miller RL, Imbertson LM, Reiter MJ and Gerster JF: Treatment of primary herpes simplex virus infection in guinea pigs by imiquimod. Antiviral Res. 44:31–42. 1999.PubMed/NCBI View Article : Google Scholar

16 

Schacker TW, Conant M, Thoming C, Stanczak T, Wang Z and Smith M: Imiquimod 5-Percent cream does not alter the natural history of recurrent herpes genitalis: A phase II, Randomized, double-blind, placebo-controlled study. Antimicrob Agents Chemother. 46:3243–3248. 2002.PubMed/NCBI View Article : Google Scholar

17 

Winters U, Daayana S, Lear JT, Tomlinson AE, Elkord E, Stern PL and Kitchener HC: Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia. Clin Cancer Res. 14:5292–5299. 2008.PubMed/NCBI View Article : Google Scholar

18 

Wouters T, Hendriks N, Koeneman M, Kruse AJ, van de Sande A, van Beekhuizen HJ, Gerestein KG, Bekkers RLM and Piek JMJ: Systemic adverse events in Imiquimod use for cervical intraepithelial neoplasia-A case series. Case Rep Womens Health. 21(e00105)2019.PubMed/NCBI View Article : Google Scholar

19 

Lebwohl M, Dinehart S, Whiting D, Lee PK, Tawfik N, Jorizzo J, Lee JH and Fox TL: Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol. 50:714–721. 2004.PubMed/NCBI View Article : Google Scholar

20 

Geisse J, Caro I, Lindholm J, Golitz L, Stampone P and Owens M: Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from two phase III, randomized, vehicle-controlled studies. J Am Acad Dermatol. 50:722–733. 2004.PubMed/NCBI View Article : Google Scholar

21 

Ackerman SE, Gonzalez JC, Gregorio JD, Paik JC, Hartmann FJ, Kenkel JA, Lee A, Luo A, Pearson CI, Nguyen ML, et al: Abstract 1559: TLR7/8 immune-stimulating antibody conjugates elicit robust myeloid activation leading to enhanced effector function and anti-tumorimmunity in pre-clinical models. Cancer Res. 79 (13 Suppl)(S1559)2019.

22 

Ackerman SE, Pearson CI, Gregorio JD, Gonzalez JC, Kenkel JA, Hartmann FJ, Luo A, Ho PY, LeBlanc H, Blum LK, et al: Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity. Nat Cancer. 2:18–33. 2021.PubMed/NCBI View Article : Google Scholar

23 

Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS and Miller JS: First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin Cancer Res. 13:7119–7125. 2007.PubMed/NCBI View Article : Google Scholar

24 

Hänel G, Angerer C, Petry K, Lichtenegger FS and Subklewe M: Blood DCs activated with R848 and poly (I: C) induce antigen-specific immune responses against viral and tumor-associated antigens. Cancer Immunol Immunother. 71:1705–1718. 2022.PubMed/NCBI View Article : Google Scholar

25 

Anfray C, Mainini F, Digifico E, Maeda A, Sironi M, Erreni M, Anselmo A, Ummarino A, Gandoy S, Expósito F, et al: Intratumoral combination therapy with poly(I:C) and Resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity. J Immunother Cancer. 9(e002408)2021.PubMed/NCBI View Article : Google Scholar

26 

Pearson FE, Chang K, Minoda Y, Rojas IML, Haigh OL, Daraj G, Tullett KM and Radford KJ: Activation of human CD141(+) and CD1c(+) dendritic cells in vivo with combined TLR3 and TLR7/8 ligation. Immunol Cell Biol. 96:390–400. 2018.PubMed/NCBI View Article : Google Scholar

27 

Sajadian A, Tabarraei A, Soleimanjahi H, Fotouhi F, Gorji A and Ghaemi A: Comparing the effect of Toll-like receptor agonist adjuvants on the efficiency of a DNA vaccine. Arch Virol. 159:1951–1960. 2014.PubMed/NCBI View Article : Google Scholar

28 

Gierlich P, Lex V, Technau A, Keupp A, Morper L, Glunz A, Sennholz H, Rachor J, Sauer S, Marcu A, et al: Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8(+) T-cells. Cancer Immunol Immunother. 69:1029–1042. 2020.PubMed/NCBI View Article : Google Scholar

29 

Caisova V, Uher O, Nedbalova P, Jochmanova I, Kvardova K, Masakova K, Krejcova G, Padoukova L, Chmelar J, Kopecky J and Ženka J: Effective cancer immunotherapy based on the combination of TLR agonists with stimulation of phagocytosis. Int Immunopharmacol. 59:86–96. 2018.PubMed/NCBI View Article : Google Scholar

30 

Liu Z, Xie Y, Xiong Y, Liu S, Qiu C, Zhu Z, Mao H, Yu M and Wang X: TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages. Cancer Lett. 469:173–185. 2020.PubMed/NCBI View Article : Google Scholar

31 

Liu C, Han C and Liu J: The role of toll-like receptors in oncotherapy. Oncol Res. 27:965–978. 2019.PubMed/NCBI View Article : Google Scholar

32 

Cho JH, Lee HJ, Ko HJ, Yoon BI, Choe J, Kim KC, Hahn TW, Han JA, Choi SS, Jung YM, et al: The TLR7 agonist Imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma. Oncotarget. 8:24932–24948. 2017.PubMed/NCBI View Article : Google Scholar

33 

Chen Q, Xu L, Liang C, Wang C, Peng R and Liu Z: Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat Commun. 7(13193)2016.PubMed/NCBI View Article : Google Scholar

34 

Lin W, Li C, Xu N, Watanabe M, Xue R, Xu A, Araki M, Sun R, Liu C, Nasu Y and Huang P: Dual-Functional PLGA nanoparticles co-loaded with indocyanine green and resiquimod for prostate cancer treatment. Int J Nanomed. 16:2775–2787. 2021.PubMed/NCBI View Article : Google Scholar

35 

Zhang H, Tang WL, Kheirolomoom A, Fite BZ, Wu B, Lau K, Baikoghli M, Raie MN, Tumbale SK, Foiret J, et al: Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy. J Control Release. 330:1080–1094. 2021.PubMed/NCBI View Article : Google Scholar

36 

Li J, Yu X, Jiang Y, He S, Zhang Y, Luo Y and Pu K: Second near-infrared photothermal semiconducting polymer nanoadjuvant for enhanced cancer immunotherapy. Adv Mater. 33(e2003458)2021.PubMed/NCBI View Article : Google Scholar

37 

Noman MZ, Parpal S, Van Moer K, Xiao ML, Yu Y, Viklund J, De Milito A, Hasmim M, Andersson M, Amaravadi RK, et al: Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy. Sci Adv. 6(eaax7881)2020.PubMed/NCBI View Article : Google Scholar

38 

Shakhnovich V, Meibohm B, Rosenberg A, Kierzek AM, Hasenkamp R, Funk RS, Thalhauser CJ, van der Graaf PH, Wang YC and Hamuro L: Immunogenicity in clinical practice and drug development: When is it significant? Clin Transl Sci. 13:219–223. 2020.PubMed/NCBI View Article : Google Scholar

39 

Zhang R, Jia M, Lv H, Li M, Ding G, Cheng G and Li J: Assembling Au8 clusters on surfaces of bifunctional nanoimmunomodulators for synergistically enhanced low dose radiotherapy of metastatic tumor. J Nanobiotechnology. 22(20)2024.PubMed/NCBI View Article : Google Scholar

40 

Zahm CD, Colluru VT, McIlwain SJ, Ong IM and McNeel DG: TLR stimulation during T-cell activation lowers PD-1 expression on CD8(+) T-cells. Cancer Immunol Res. 6:1364–1374. 2018.PubMed/NCBI View Article : Google Scholar

41 

Costa Svedman F, Jalsenius M, Höiom V, Grozman V, Bergqvist M, Söderdahl F, Eriksson H, Rotstein S, Ny L, Ascierto PA, et al: Plasma thymidine kinase activity as a novel biomarker in metastatic melanoma patients treated with immune checkpoint inhibitors. Cancers (Basel). 14(702)2022.PubMed/NCBI View Article : Google Scholar

42 

Rizzo A, Ricci AD and Brandi G: Pd-L1, TMB, MSI, and other predictors of response to immune checkpoint inhibitors in biliary tract cancer. Cancers (Basel). 13(553)2021.PubMed/NCBI View Article : Google Scholar

43 

Shen X and Zhao B: Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: Meta-analysis. BMJ. 362(k3529)2018.PubMed/NCBI View Article : Google Scholar

44 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021.PubMed/NCBI View Article : Google Scholar

45 

Wang X, Piantadosi S, Le-Rademacher J and Mandrekar SJ: Statistical considerations for subgroup analyses. J Thorac Oncol. 16:375–380. 2021.PubMed/NCBI View Article : Google Scholar

46 

Riley RS, June CH, Langer R and Mitchell MJ: Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 18:175–196. 2019.PubMed/NCBI View Article : Google Scholar

47 

Jin SM, Lee SN, Kim JE, Yoo YJ, Song C, Shin HS, Phuengkham H, Lee CH, Um SH and Lim YT: Overcoming chemoimmunotherapy-induced immunosuppression by assemblable and depot forming immune modulating nanosuspension. Adv Sci (Weinh). 8(2102043)2021.PubMed/NCBI View Article : Google Scholar

48 

Fang X, Lan H, Jin K, Gong D and Qian J: Nanovaccines for cancer prevention and immunotherapy: An update review. Cancers (Basel). 14(3842)2022.PubMed/NCBI View Article : Google Scholar

49 

Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, et al: Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 369:122–133. 2013.PubMed/NCBI View Article : Google Scholar

50 

Muraoka D, Seo N, Hayashi T, Tahara Y, Fujii K, Tawara I, Miyahara Y, Okamori K, Yagita H, Imoto S, et al: Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance. J Clin Invest. 129:1278–1294. 2019.PubMed/NCBI View Article : Google Scholar

51 

Garrido-Martin EM, Mellows TWP, Clarke J, Ganesan AP, Wood O, Cazaly A, Seumois G, Chee SJ, Alzetani A, King EV, et al: M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer. J Immunother Cancer. 8(e000778)2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bhaliya KR, Anwer M, Munn A and Wei MQ: New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review). Mol Clin Oncol 22: 4, 2025.
APA
Bhaliya, K.R., Anwer, M., Munn, A., & Wei, M.Q. (2025). New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review). Molecular and Clinical Oncology, 22, 4. https://doi.org/10.3892/mco.2024.2799
MLA
Bhaliya, K. R., Anwer, M., Munn, A., Wei, M. Q."New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)". Molecular and Clinical Oncology 22.1 (2025): 4.
Chicago
Bhaliya, K. R., Anwer, M., Munn, A., Wei, M. Q."New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)". Molecular and Clinical Oncology 22, no. 1 (2025): 4. https://doi.org/10.3892/mco.2024.2799
Copy and paste a formatted citation
x
Spandidos Publications style
Bhaliya KR, Anwer M, Munn A and Wei MQ: New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review). Mol Clin Oncol 22: 4, 2025.
APA
Bhaliya, K.R., Anwer, M., Munn, A., & Wei, M.Q. (2025). New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review). Molecular and Clinical Oncology, 22, 4. https://doi.org/10.3892/mco.2024.2799
MLA
Bhaliya, K. R., Anwer, M., Munn, A., Wei, M. Q."New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)". Molecular and Clinical Oncology 22.1 (2025): 4.
Chicago
Bhaliya, K. R., Anwer, M., Munn, A., Wei, M. Q."New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)". Molecular and Clinical Oncology 22, no. 1 (2025): 4. https://doi.org/10.3892/mco.2024.2799
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