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Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy

  • Authors:
    • Fengming Luan
    • Shenbin Xu
    • Ke Chen
    • Kaibo Chen
    • Muxing Kang
    • Guofeng Chen
    • Jian Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Luan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
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    Published online on: December 12, 2024
       https://doi.org/10.3892/mco.2024.2812
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Abstract

The present study aimed to determine the potential of carcinoembryonic antigen (CEA), alpha‑fetoprotein (AFP), carbohydrate antigen (CA)19‑9 and CA242 in predicting recurrence/metastasis of gastric cancer in patients following radical gastrectomy. The clinical data of 368 patients with stage I‑III gastric cancer who underwent radical gastrectomy were analyzed, and CEA, AFP, CA19‑9 and CA242 levels were detected prior to surgery and 6‑12 months following surgery. Univariate and multivariate analyses were used to evaluate the potential risk factors for post‑operative recurrence/metastasis of gastric cancer, and the predictive value of CEA, AFP, CA19‑9 and CA242 levels was evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC). Cumulative survival rates were calculated using Kaplan‑Meier analysis, and statistical significance was evaluated using a log‑rank test. Results of the univariate analysis demonstrated that open surgery, age ≥70, total gastrectomy, disease stage III, and pre‑operative CA19‑9 and CA242 positivity were risk factors for recurrence/metastasis. ROC curve analysis revealed that the AUC values of postoperative CA19‑9 were higher than other values. According to the Kaplan‑Meier survival analysis, patients with negative CEA, AFP, CA19‑9 and CA242 levels prior to surgery exhibited a higher five‑year survival rate than those who exhibited positive levels of these tumor markers. In addition, patients with positive CEA, AFP, CA19‑9 and CA242 levels prior to surgery exhibited a significantly worse prognosis. Collectively, the results of the present study indicated that CEA, AFP, CA19‑9 and CA242 exhibited potential as predictive biomarkers for recurrence/metastasis following radical gastrectomy in patients with gastric cancer. Notably, CA19‑9 and CA242 may exhibit the highest potential in predicting recurrence/metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Luan F, Xu S, Chen K, Chen K, Kang M, Chen G and Chen J: Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy. Mol Clin Oncol 22: 17, 2025.
APA
Luan, F., Xu, S., Chen, K., Chen, K., Kang, M., Chen, G., & Chen, J. (2025). Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy. Molecular and Clinical Oncology, 22, 17. https://doi.org/10.3892/mco.2024.2812
MLA
Luan, F., Xu, S., Chen, K., Chen, K., Kang, M., Chen, G., Chen, J."Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy". Molecular and Clinical Oncology 22.2 (2025): 17.
Chicago
Luan, F., Xu, S., Chen, K., Chen, K., Kang, M., Chen, G., Chen, J."Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy". Molecular and Clinical Oncology 22, no. 2 (2025): 17. https://doi.org/10.3892/mco.2024.2812
Copy and paste a formatted citation
x
Spandidos Publications style
Luan F, Xu S, Chen K, Chen K, Kang M, Chen G and Chen J: Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy. Mol Clin Oncol 22: 17, 2025.
APA
Luan, F., Xu, S., Chen, K., Chen, K., Kang, M., Chen, G., & Chen, J. (2025). Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy. Molecular and Clinical Oncology, 22, 17. https://doi.org/10.3892/mco.2024.2812
MLA
Luan, F., Xu, S., Chen, K., Chen, K., Kang, M., Chen, G., Chen, J."Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy". Molecular and Clinical Oncology 22.2 (2025): 17.
Chicago
Luan, F., Xu, S., Chen, K., Chen, K., Kang, M., Chen, G., Chen, J."Prognostic effect of CEA, AFP, CA19‑9 and CA242 for recurrence/metastasis of gastric cancer following radical gastrectomy". Molecular and Clinical Oncology 22, no. 2 (2025): 17. https://doi.org/10.3892/mco.2024.2812
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