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Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma

  • Authors:
    • Teijiro Hirashita
    • Kazuhiro Tada
    • Yuiko Nagasawa
    • Hiroki Orimoto
    • Masahiro Kawamura
    • Atsuro Fujinaga
    • Hiroomi Takayama
    • Yoko Kawano
    • Takashi Masuda
    • Yuichi Endo
    • Masafumi Inomata
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan
    Copyright: © Hirashita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
    |
    Published online on: December 12, 2024
       https://doi.org/10.3892/mco.2024.2813
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Abstract

Currently, neoadjuvant chemotherapy (NAC) is usually performed even for resectable pancreatic ductal adenocarcinoma (rPDAC). The present study investigated the benefits of NAC with gemcitabine plus S-1 for rPDAC. The medical records of 170 patients diagnosed as having rPDAC based on preoperative imaging were reviewed retrospectively. Clinicopathological factors in the NAC group were compared with those in the upfront surgery (UpS) group. NAC was administered to 30 of the 170 patients. The period from first visit to treatment in the NAC group was shorter than that in the UpS group (P<0.001). Staging laparoscopy detected occult distant metastases in 12 of the 170 patients (7%), of whom all 12 were in the UpS group. All patients in the NAC group underwent surgical resection (P=0.028). Among the 158 patients who underwent pancreatectomy, the NAC group showed rapid induction of the treatment, non-inferior operative outcomes and a higher R0 rate compared with the UpS group. Rates of early recurrence (within 6 months) after surgery were 10% (3/30) in the NAC group and 29% (37/128) in the UpS group (P=0.021). NAC for rPDAC is beneficial in terms of rapid induction of the treatment, fewer occult metastases, and lower rate of early recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Hirashita T, Tada K, Nagasawa Y, Orimoto H, Kawamura M, Fujinaga A, Takayama H, Kawano Y, Masuda T, Endo Y, Endo Y, et al: Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma. Mol Clin Oncol 22: 18, 2025.
APA
Hirashita, T., Tada, K., Nagasawa, Y., Orimoto, H., Kawamura, M., Fujinaga, A. ... Inomata, M. (2025). Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma. Molecular and Clinical Oncology, 22, 18. https://doi.org/10.3892/mco.2024.2813
MLA
Hirashita, T., Tada, K., Nagasawa, Y., Orimoto, H., Kawamura, M., Fujinaga, A., Takayama, H., Kawano, Y., Masuda, T., Endo, Y., Inomata, M."Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 22.2 (2025): 18.
Chicago
Hirashita, T., Tada, K., Nagasawa, Y., Orimoto, H., Kawamura, M., Fujinaga, A., Takayama, H., Kawano, Y., Masuda, T., Endo, Y., Inomata, M."Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 22, no. 2 (2025): 18. https://doi.org/10.3892/mco.2024.2813
Copy and paste a formatted citation
x
Spandidos Publications style
Hirashita T, Tada K, Nagasawa Y, Orimoto H, Kawamura M, Fujinaga A, Takayama H, Kawano Y, Masuda T, Endo Y, Endo Y, et al: Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma. Mol Clin Oncol 22: 18, 2025.
APA
Hirashita, T., Tada, K., Nagasawa, Y., Orimoto, H., Kawamura, M., Fujinaga, A. ... Inomata, M. (2025). Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma. Molecular and Clinical Oncology, 22, 18. https://doi.org/10.3892/mco.2024.2813
MLA
Hirashita, T., Tada, K., Nagasawa, Y., Orimoto, H., Kawamura, M., Fujinaga, A., Takayama, H., Kawano, Y., Masuda, T., Endo, Y., Inomata, M."Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 22.2 (2025): 18.
Chicago
Hirashita, T., Tada, K., Nagasawa, Y., Orimoto, H., Kawamura, M., Fujinaga, A., Takayama, H., Kawano, Y., Masuda, T., Endo, Y., Inomata, M."Benefits of neoadjuvant chemotherapy with gemcitabine plus S-1 for resectable pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 22, no. 2 (2025): 18. https://doi.org/10.3892/mco.2024.2813
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