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Article Open Access

Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer

  • Authors:
    • Yijiang Liu
    • Huijing Tao
    • Shengjun Jia
    • Haozheng Wang
    • Long Guo
    • Zhuozheng Hu
    • Wenxiong Zhang
    • Fei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Urology Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 19
    |
    Published online on: December 13, 2024
       https://doi.org/10.3892/mco.2024.2814
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Abstract

Disulfidptosis, which was recently identified, has shown promise as a potential cancer treatment. Nonetheless, the precise role of long non‑coding RNAs (lncRNAs) in this phenomenon is currently unclear. To elucidate their significance in bladder cancer (BLCA), a signature of disulfidptosis‑related lncRNAs (DRlncRNAs) was developed and their potential prognostic significance was explored. BLCA sample data were sourced from The Cancer Genome Atlas. A predictive signature comprising DRlncRNAs was formulated and subsequently validated. The combination of this signature with clinical characteristics facilitated the development of a nomogram with practical clinical utility. Additionally, enrichment analysis was conducted, the tumor microenvironment (TME) was assessed, the tumor mutational burden (TMB) was analyzed, and drug sensitivity was explored. Reverse transcription‑quantitative PCR (RT‑qPCR) was utilized to quantify lncRNA expression. The results revealed an eight‑gene signature based on DRlncRNAs was established, and the predictive accuracy of the nomogram that incorporated the risk score [area under the curve (AUC)=0.733] outperformed the nomogram without it (AUC=0.703). High‑risk groups were associated with pathways such as WNT signaling, focal adhesion and cell cycle pathways. The TME study revealed that high‑risk patients had increased immune infiltration, whereas the TMB and tumor immune dysfunction and exclusion scores in low‑risk patients indicated a potentially robust immune response. Drug sensitivity analysis identified appropriate antitumor drugs for each group. RT‑qPCR experiments validated significant differences in DRlncRNAs expression between normal and BLCA cell lines. In conclusion, the prognostic risk signature, which includes the eight identified DRlncRNAs, demonstrates promise for predicting prognosis of patients with BLCA and guiding the selection of suitable immunotherapy and chemotherapy strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Tao H, Jia S, Wang H, Guo L, Hu Z, Zhang W and Liu F: Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer. Mol Clin Oncol 22: 19, 2025.
APA
Liu, Y., Tao, H., Jia, S., Wang, H., Guo, L., Hu, Z. ... Liu, F. (2025). Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer. Molecular and Clinical Oncology, 22, 19. https://doi.org/10.3892/mco.2024.2814
MLA
Liu, Y., Tao, H., Jia, S., Wang, H., Guo, L., Hu, Z., Zhang, W., Liu, F."Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer". Molecular and Clinical Oncology 22.2 (2025): 19.
Chicago
Liu, Y., Tao, H., Jia, S., Wang, H., Guo, L., Hu, Z., Zhang, W., Liu, F."Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer". Molecular and Clinical Oncology 22, no. 2 (2025): 19. https://doi.org/10.3892/mco.2024.2814
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Tao H, Jia S, Wang H, Guo L, Hu Z, Zhang W and Liu F: Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer. Mol Clin Oncol 22: 19, 2025.
APA
Liu, Y., Tao, H., Jia, S., Wang, H., Guo, L., Hu, Z. ... Liu, F. (2025). Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer. Molecular and Clinical Oncology, 22, 19. https://doi.org/10.3892/mco.2024.2814
MLA
Liu, Y., Tao, H., Jia, S., Wang, H., Guo, L., Hu, Z., Zhang, W., Liu, F."Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer". Molecular and Clinical Oncology 22.2 (2025): 19.
Chicago
Liu, Y., Tao, H., Jia, S., Wang, H., Guo, L., Hu, Z., Zhang, W., Liu, F."Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer". Molecular and Clinical Oncology 22, no. 2 (2025): 19. https://doi.org/10.3892/mco.2024.2814
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