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Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort

  • Authors:
    • Yonghong Li
    • Wei Li
    • Yirui Liu
    • Yi Peng
    • Jing Tang
    • Xiaobing Li
  • View Affiliations / Copyright

    Affiliations: The Department of Oncology, The First People's Hospital of Tianmen, Tianmen, Hubei 431700, P.R. China, The Department of Oncology, The First People's Hospital of Tianmen, Tianmen, Hubei 431700, P.R. China, Department of Nursing, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China, Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China, Department of Lymphoma, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China, Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 21
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    Published online on: December 19, 2024
       https://doi.org/10.3892/mco.2024.2816
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Abstract

The aim of the present study was to investigate the efficacy and safety of anlotinib combined with vinorelbine (NVB) as a second‑line treatment for elderly patients with advanced squamous cell lung carcinoma (SqCLC). The present retrospective analysis included 48 elderly patients (aged ≥65 years) diagnosed with advanced SqCLC who received anlotinib in combination with NVB as a second‑line therapy between January 2021 and December 2023. The primary endpoints assessed were overall survival (OS), progression‑free survival (PFS), objective response rate (ORR), disease control rate (DCR) and safety profile. The median PFS and OS for the cohort was found to be 5.0 and 9.5 months, respectively. By contrast, the ORR and DCR were found to be 29.17 and 70.83%. Further subgroup analysis indicated that patients who experienced specific adverse events (AEs), such as hypertension, proteinuria and hand‑foot syndrome during treatment, generally had superior efficacy compared with those who did not experience these AEs (mPFS, 6.0 vs. 4.0 months; mOS, 11.0 vs. 8.5 months). In addition, apart from promising efficacy, patients who experienced common AEs also experienced decreased appetite (35.42%), fatigue (29.17%), hypertension (25%) and hand‑foot syndrome (27.08%). Grade 3 or higher AEs occurred in <30% of patients, the majority of which was alleviated through corresponding support care. These results suggest that the combination of anlotinib and NVB as second‑line therapy for elderly patients with advanced SqCLC demonstrated promising efficacy and a manageable safety profile. Such regimen may be a viable treatment option for this patient population. However, further prospective studies are required to validate these findings and optimize the dosing schedule for improved therapeutic outcomes.
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1 

Hsu EC, Wu KL, Tsai YM, Lee MH, Tsai MJ, Kuo CY, Liu YC, Liang FW, Yang CJ and Hung JY: Real-world treatment pattern and prognostic factors of stage IV lung squamous cell carcinoma patients. Kaohsiung J Med Sci. 38:1001–1011. 2022.PubMed/NCBI View Article : Google Scholar

2 

Ganti AK, Klein AB, Cotarla I, Seal B and Chou E: Update of incidence, prevalence, survival, and initial treatment in patients with non-small cell lung cancer in the US. JAMA Oncol. 7:1824–1832. 2021.PubMed/NCBI View Article : Google Scholar

3 

Santos ES and Rodriguez E: Treatment considerations for patients with advanced squamous cell carcinoma of the lung. Clin Lung Cancer. 23:457–466. 2022.PubMed/NCBI View Article : Google Scholar

4 

Basnet A, Alahmadi A and Gajra A: Older patients with lung cancer: A summary of seminal contributions to optimal patient care. Curr Oncol Rep. 24:1607–1618. 2022.PubMed/NCBI View Article : Google Scholar

5 

Novello S, Kowalski DM, Luft A, Gümüş M, Vicente D, Mazières J, Rodríguez-Cid J, Tafreshi A, Cheng Y, Lee KH, et al: Pembrolizumab plus chemotherapy in squamous non-small-cell lung cancer: 5-year update of the phase III KEYNOTE-407 Study. J Clin Oncol. 41:1999–2006. 2023.PubMed/NCBI View Article : Google Scholar

6 

Uprety D, Remon J and Peters S: First-line dual immunotherapy, a treatment option in first-line metastatic non-small-cell lung cancer: Are we ready to use it? J Clin Oncol. 42:378–382. 2024.PubMed/NCBI View Article : Google Scholar

7 

Lau SCM, Pan Y, Velcheti V and Wong KK: Squamous cell lung cancer: Current landscape and future therapeutic options. Cancer Cell. 40:1279–1293. 2022.PubMed/NCBI View Article : Google Scholar

8 

Filipits M: New developments in the treatment of squamous cell lung cancer. Curr Opin Oncol. 26:152–158. 2014.PubMed/NCBI View Article : Google Scholar

9 

Han B, Li K, Wang Q, Zhang L, Shi J, Wang Z, Cheng Y, He J, Shi Y, Zhao Y, et al: Effect of anlotinib as a third-line or further treatment on overall survival of patients with advanced non-small cell lung cancer: The ALTER 0303 phase 3 randomized clinical trial. JAMA Oncol. 4:1569–1575. 2018.PubMed/NCBI View Article : Google Scholar

10 

Zhang C, Kong FW, Wu WB, Zhang M, Yu GM, Wang X and Liu YY: First-line pemetrexed and carboplatin plus anlotinib for epidermal growth factor receptor wild-type and anaplastic lymphoma kinase-negative lung adenocarcinoma with brain metastasis: A case report and review of the literature. Medicine (Baltimore). 99(e22128)2020.PubMed/NCBI View Article : Google Scholar

11 

Jiang S, Liang H, Liu Z, Zhao S, Liu J, Xie Z, Wang W, Zhang Y, Han B, He J and Liang W: The impact of anlotinib on brain metastases of non-small cell lung cancer: Post Hoc Analysis of a Phase III Randomized Control Trial (ALTER0303). Oncologist. 25:e870–e874. 2020.PubMed/NCBI View Article : Google Scholar

12 

Capasso A: Vinorelbine in cancer therapy. Curr Drug Targets. 13:1065–1071. 2012.PubMed/NCBI View Article : Google Scholar

13 

Bilir C, Durak S, Kızılkaya B, Hacıbekiroglu I, Nayır E and Engin H: Efficacy of metronomic vinorelbine in elderly patients with advanced non-small-cell lung cancer and poor performance status. Curr Oncol. 24:e199–e204. 2017.PubMed/NCBI View Article : Google Scholar

14 

Platania M, Pasini F, Porcu L, Boeri M, Verderame F, Modena Y, Del Conte A, Nichetti F, Garassino MC, Martinetti A, et al: Oral maintenance metronomic vinorelbine versus best supportive care in advanced non-small-cell lung cancer after platinum-based chemotherapy: The MA.NI.LA. multicenter, randomized, controlled, phase II trial. Lung Cancer. 132:17–23. 2019.PubMed/NCBI View Article : Google Scholar

15 

Grossi F, Jaśkiewicz P, Ferreira M, Czyżewicz G, Kowalski D, Ciuffreda L, Garcia-Gomez R, Caruso S, Bosch-Barrera J, Gautier S, et al: Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: A prospective randomized international phase II study (NAVoTrial 03). Ther Adv Med Oncol. 13(17588359211022905)2021.PubMed/NCBI View Article : Google Scholar

16 

Rossi D, Lippe P, Rocchi MBL, Sarti D, Catalano V, Graziano F, Giordani P, Baldelli A, Fedeli SL, Imperatori L, et al: Metronomic oral vinorelbine: an alternative schedule in elderly and patients PS2 with local/advanced and metastatic NSCLC Not Oncogene-addicted. In Vivo. 34:2687–2691. 2020.PubMed/NCBI View Article : Google Scholar

17 

D'Ascanio M, Pezzuto A, Fiorentino C, Sposato B, Bruno P, Grieco A, Mancini R and Ricci A: Metronomic chemotherapy with vinorelbine produces clinical benefit and low toxicity in frail elderly patients affected by advanced non-small cell lung cancer. Biomed Res Int. 2018(6278403)2018.PubMed/NCBI View Article : Google Scholar

18 

Xiang M, Yang X, Ren S, Du H, Geng L, Yuan L, Wen Y, Lin B, Li J, Zhang Y, et al: Anlotinib combined with S-1 in third- or later-line stage IV non-small cell lung cancer treatment: A phase II clinical trial. Oncologist. 26:e2130–e2135. 2021.PubMed/NCBI View Article : Google Scholar

19 

Li DD, Tao ZH, Wang BY, Wang LP, Cao J, Hu XC and Zhang J: Apatinib plus vinorelbine versus vinorelbine for metastatic triple-negative breast cancer who failed first/second-line treatment: the NAN trial. NPJ Breast Cancer. 8(110)2022.PubMed/NCBI View Article : Google Scholar

20 

Huang JY, Chen XL, Xie XF, Song L, Chen LP, Lan XF, Bai X, Chen X and Du CW: The efficiency and safety of low-dose apatinib combined with oral vinorelbine in pretreated HER2-negative metastatic breast cancer. Cancer Med. 13(e7181)2024.PubMed/NCBI View Article : Google Scholar

21 

Xu H, Lv D, Meng Y, Wang M, Wang W, Zhou C, Zhou S, Chen X and Yang H: Endostar improved efficacy of concurrent chemoradiotherapy with vinorelbine plus carboplatin in locally advanced lung squamous cell carcinoma patients with high serum Lp(a) concentration. Ann Palliat Med. 9:298–307. 2020.PubMed/NCBI View Article : Google Scholar

22 

Ito K, Hamamichi S, Abe T, Akagi T, Shirota H, Kawano S, Asano M, Asano O, Yokoi A, Matsui J, et al: Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models. Cancer Sci. 108:2273–2280. 2017.PubMed/NCBI View Article : Google Scholar

23 

Liao BC, Shao YY, Chen HM, Shau WY, Lin ZZ, Kuo RN, Lai CL, Chen KH, Cheng AL, Yang JC and Lai MS: Comparative effectiveness of first-line platinum-based chemotherapy regimens for advanced lung squamous cell carcinoma. Clin Lung Cancer. 16:137–143. 2015.PubMed/NCBI View Article : Google Scholar

24 

Li X, Wu D, Tang J and Wu Y: The efficiency and safety of triple-drug combination of albumin-bound paclitaxel, anlotinib and PD-1/L1 Inhibitors in the 2(nd) or above line of advanced NSCLC: A retrospective cohort study. Cancer Manag Res. 16:1003–1012. 2024.PubMed/NCBI View Article : Google Scholar

25 

Tang J, Jiang H, Xiang Z, Zhu X, Xie R, Wu D, Peng L and Li X: Apatinib plus docetaxel or pemetrexed shows promising activities against non-small cell lung cancer with brain metastasis: A retrospective analysis. J Thorac Dis. 16:615–622. 2024.PubMed/NCBI View Article : Google Scholar

26 

Yin C, Zou GR, He Y, Li J, Yan HW, Su Z, Cao XL and Li XB: Efficiency and toxicity of nab-paclitaxel and camrelizumab in the second or above line treatment of advanced non-small cell lung cancer: A retrospective cohort study. J Thorac Dis. 15:1838–1847. 2023.PubMed/NCBI View Article : Google Scholar

27 

Wang L, He Z, Yang S, Tang H, Wu Y, Li S, Han B, Li K, Zhang L, Shi J, et al: The impact of previous therapy strategy on the efficiency of anlotinib hydrochloride as a third-line treatment on patients with advanced non-small cell lung cancer (NSCLC): A subgroup analysis of ALTER0303 trial. Transl Lung Cancer Res. 8:575–583. 2019.PubMed/NCBI View Article : Google Scholar

28 

Zhang X, Xiong Y, Xia Q, Wu F, Liu L, Zhou Y, Zeng L, Zhou C, Xia C, Jiang W, et al: Efficacy and safety of apatinib plus vinorelbine in patients with wild-type advanced non-small cell lung cancer after second-line treatment failure: A nonrandomized clinical trial. JAMA Netw Open. 3(e201226)2020.PubMed/NCBI View Article : Google Scholar

29 

Howard FM and Pearson AT: Prognosis and treatment of non-small cell lung cancer in the age of deep learning. JAMA Netw Open. 3(e206368)2020.PubMed/NCBI View Article : Google Scholar

30 

Kukulj S, Aukst Margetic B, Jakovljevic M and Samarzija M: Temperament and character and quality of life in lung cancer patients. Tumori. 99:708–714. 2013.PubMed/NCBI View Article : Google Scholar

31 

Okamoto J, Kubokura H and Usuda J: Factors determining the choice of surgical procedure in elderly patients with non-small cell lung cancer. Ann Thorac Cardiovasc Surg. 22:131–138. 2016.PubMed/NCBI View Article : Google Scholar

32 

Chen K, Yang D, Li F, Gao L, Tian Y, Xu B, Xu X, Xu Q and Cao J: Changes in the symptom clusters of elderly patients with lung cancer over the course of postoperative rehabilitation and their correlation with frailty and quality of life: A longitudinal study. Eur J Oncol Nurs. 67(102388)2023.PubMed/NCBI View Article : Google Scholar

33 

She J, Yang P, Hong Q and Bai C: Lung cancer in China: Challenges and interventions. Chest. 143:1117–1126. 2023.PubMed/NCBI View Article : Google Scholar

34 

Kwan SW, Mortell KE, Talenfeld AD and Brunner MC: Thermal ablation matches sublobar resection outcomes in older patients with early-stage non-small cell lung cancer. J Vasc Interv Radiol. 25:1–9.e1. 2014.PubMed/NCBI View Article : Google Scholar

35 

Fang Z, He J, Fang W, Ruan L and Fang F: Long-term outcomes of thoracoscopic anatomic resections and systematic lymphadenectomy for elderly high-risk patients with stage IB non-small-cell lung cancer. Heart Lung Circ. 25:392–397. 2016.PubMed/NCBI View Article : Google Scholar

36 

Ye X, Liu Y, Yang J, Wang Y, Cui X, Xie H, Song L, Ding Z, Zhai R, Han Y, et al: Do older patients with stage IB non-small-cell lung cancer obtain survival benefits from surgery? A propensity score matching study using SEER data. Eur J Surg Oncol. 48:1954–1963. 2022.PubMed/NCBI View Article : Google Scholar

37 

Lee SM, Schulz C, Prabhash K, Kowalski D, Szczesna A, Han B, Rittmeyer A, Talbot T, Vicente D, Califano R, et al: First-line atezolizumab monotherapy versus single-agent chemotherapy in patients with non-small-cell lung cancer ineligible for treatment with a platinum-containing regimen (IPSOS): A phase 3, global, multicentre, open-label, randomised controlled study. Lancet. 402:451–463. 2023.PubMed/NCBI View Article : Google Scholar

38 

Sun L, Zhao Q, Wang Y, Wang Y, Zheng M, Ding X and Miao L: Efficacy and safety of anlotinib-containing regimens in advanced non-small cell lung cancer: A real-world study. Int J Gen Med. 16:4165–4179. 2023.PubMed/NCBI View Article : Google Scholar

39 

Kokkotou E, Anagnostakis M, Evangelou G, Syrigos NK and Gkiozos I: Real-world data and evidence in lung cancer: A review of recent developments. Cancers (Basel). 16(1414)2024.PubMed/NCBI View Article : Google Scholar

40 

Nobili S, Lavacchi D, Perrone G, Vicini G, Tassi R, Landini I, Grosso A, Roviello G, Mazzanti R, Santomaggio C and Mini E: Vinorelbine in non-small cell lung cancer: Real-World data from a single-institution experience. Oncol Res. 28:237–248. 2020.PubMed/NCBI View Article : Google Scholar

41 

Wang M, Mao M, Yang Y, Cai Z, Li Y, Chen Y, Cai J and Ye Q: Safety and efficacy of anlotinib hydrochloride capsules in advanced non-small-cell lung cancer: A multicenter, real-world study. Future Oncol. 19:1729–1739. 2023.PubMed/NCBI View Article : Google Scholar

42 

Wei W, Ban X, Yang F, Li J, Cheng X, Zhang R, Huang X, Huang Y, Li Q, Qiu Y, et al: Phase II trial of efficacy, safety and biomarker analysis of sintilimab plus anlotinib for patients with recurrent or advanced endometrial cancer. J Immunother Cancer. 10(e004338)2022.PubMed/NCBI View Article : Google Scholar

43 

Jiang M, Zhang C, Hu Y, Li T, Yang G, Wang G, Zhu J, Shao C, Hou H, Zhou N, et al: Anlotinib combined with toripalimab as second-line therapy for advanced, relapsed gastric or gastroesophageal junction carcinoma. Oncologist. 27:e856–e869. 2022.PubMed/NCBI View Article : Google Scholar

44 

Alshangiti A, Chandhoke G and Ellis PM: Antiangiogenic therapies in non-small-cell lung cancer. Curr Oncol. 25 (Suppl 1):S45–S58. 2018.PubMed/NCBI View Article : Google Scholar

45 

Si X, Zhang L, Wang H, Zhang X, Wang M, Han B, Li K, Wang Q, Shi J, Wang Z, et al: Management of anlotinib-related adverse events in patients with advanced non-small cell lung cancer: Experiences in ALTER-0303. Thorac Cancer. 10:551–556. 2019.PubMed/NCBI View Article : Google Scholar

46 

Carlson K and Ocean AJ: Peripheral neuropathy with microtubule-targeting agents: Occurrence and management approach. Clin Breast Cancer. 11:73–81. 2011.PubMed/NCBI View Article : Google Scholar

47 

Noguchi E and Maeda Y: Chemotherapy-induced peripheral neuropathy. Gan To Kagaku Ryoho. 38:1773–1776. 2011.PubMed/NCBI(In Japanese).

48 

Xu B, Sun T, Wang S and Lin Y: Metronomic therapy in advanced breast cancer and NSCLC: Vinorelbine as a paradigm of recent progress. Expert Rev Anticancer Ther. 21:71–79. 2021.PubMed/NCBI View Article : Google Scholar

49 

Li X, Peng Y, Wu D, Tang J and Wu Y: Efficacy and safety of anlotinib as maintenance therapy in patients with advanced non-small cell lung cancer achieving SD post first-line chemotherapy combined with immunotherapy. J Chemother: Sep 1, 2024 (Epub ahead of print).

50 

Glorieux C, Xia X, You X, Wang Z, Han Y, Yang J, Noppe G, Meester C, Ling J, Robert A, et al: Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer. J Adv Res. 40:109–124. 2022.PubMed/NCBI View Article : Google Scholar

51 

Blumberg N: Tumor angiogenesis factor. Speculations on an approach to cancer chemotherapy. Yale J Biol Med. 47:71–81. 1974.PubMed/NCBI

52 

Cabebe E and Wakelee H: Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options Oncol. 8:15–27. 2007.PubMed/NCBI View Article : Google Scholar

53 

Zhang Y, Yang SH and Guo XL: New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer. Biomed Pharmacother. 96:659–666. 2017.PubMed/NCBI View Article : Google Scholar

54 

Laquente B, Viñals F and Germà JR: Metronomic chemotherapy: An antiangiogenic scheduling. Clin Transl Oncol. 9:93–98. 2007.PubMed/NCBI View Article : Google Scholar

55 

Wang J, Li X, Zhou J, Qiu D, Zhang M, Sun L and Li SC: Long-term survival with anlotinib as a front-line treatment in an elderly NSCLC patient: A case report. Front Oncol. 13(1043244)2023.PubMed/NCBI View Article : Google Scholar

56 

Qiang H, Chang Q, Xu J, Qian J, Zhang Y, Lei Y, Han B and Chu T: New advances in antiangiogenic combination therapeutic strategies for advanced non-small cell lung cancer. J Cancer Res Clin Oncol. 146:631–645. 2020.PubMed/NCBI View Article : Google Scholar

57 

Li X, Wu D, Tang J and Wu Y: The efficiency and safety of temozolomide and PD-1/L1 inhibitors in pretreated NSCLC with brain metastasis: A retrospective cohort. J Cancer Res Clin Oncol. 150(271)2024.PubMed/NCBI View Article : Google Scholar

58 

Niu Z, Jin R, Zhang Y and Li H: Signaling pathways and targeted therapies in lung squamous cell carcinoma: Mechanisms and clinical trials. Signal Transduct Target Ther. 7(353)2022.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Li Y, Li W, Liu Y, Peng Y, Tang J and Li X: Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort. Mol Clin Oncol 22: 21, 2025.
APA
Li, Y., Li, W., Liu, Y., Peng, Y., Tang, J., & Li, X. (2025). Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort. Molecular and Clinical Oncology, 22, 21. https://doi.org/10.3892/mco.2024.2816
MLA
Li, Y., Li, W., Liu, Y., Peng, Y., Tang, J., Li, X."Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort". Molecular and Clinical Oncology 22.2 (2025): 21.
Chicago
Li, Y., Li, W., Liu, Y., Peng, Y., Tang, J., Li, X."Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort". Molecular and Clinical Oncology 22, no. 2 (2025): 21. https://doi.org/10.3892/mco.2024.2816
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li W, Liu Y, Peng Y, Tang J and Li X: Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort. Mol Clin Oncol 22: 21, 2025.
APA
Li, Y., Li, W., Liu, Y., Peng, Y., Tang, J., & Li, X. (2025). Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort. Molecular and Clinical Oncology, 22, 21. https://doi.org/10.3892/mco.2024.2816
MLA
Li, Y., Li, W., Liu, Y., Peng, Y., Tang, J., Li, X."Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort". Molecular and Clinical Oncology 22.2 (2025): 21.
Chicago
Li, Y., Li, W., Liu, Y., Peng, Y., Tang, J., Li, X."Efficacy and safety of anlotinib combined with vinorelbine as second‑line treatment for elderly patients with advanced squamous cell lung carcinoma: A retrospective cohort". Molecular and Clinical Oncology 22, no. 2 (2025): 21. https://doi.org/10.3892/mco.2024.2816
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