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Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review)

  • Authors:
    • Junqi Huang
    • Jiajia Cheng
    • Bo Shi
    • Xiaobo Du
    • Shitian Tang
    • Binwei Lin
    • Jun Mo
    • Fenglin Yan
    • Shunyu Luo
    • Heng Yang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 23
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    Published online on: January 9, 2025
       https://doi.org/10.3892/mco.2025.2818
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Abstract

Ultra‑high dose rate radiotherapy defined as FLASH radiotherapy is a potential technology to improve local tumor therapeutic gain ratio. It relies on linear accelerator capable of delivering large doses in a single microsecond pulse (>40 Gy/sec). This therapy would lead to sparing of normal tissue which has been termed the FLASH effect. As significant reduction of radiation‑induced toxicity, a greater dose of FLASH radiotherapy could be administered in tumor region. Some evidences prove the relation between FLASH effect and oxygen. Yet, the underlying physicochemical and biological mechanism remain to be fully demonstrated. The current hypotheses that may explain the normal and tumor tissue different response were We summarized and the future direction of study and clinic implementation was proposed.
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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Cheng J, Shi B, Du X, Tang S, Lin B, Mo J, Yan F, Luo S, Yang H, Yang H, et al: Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review). Mol Clin Oncol 22: 23, 2025.
APA
Huang, J., Cheng, J., Shi, B., Du, X., Tang, S., Lin, B. ... Yang, H. (2025). Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review). Molecular and Clinical Oncology, 22, 23. https://doi.org/10.3892/mco.2025.2818
MLA
Huang, J., Cheng, J., Shi, B., Du, X., Tang, S., Lin, B., Mo, J., Yan, F., Luo, S., Yang, H."Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review)". Molecular and Clinical Oncology 22.3 (2025): 23.
Chicago
Huang, J., Cheng, J., Shi, B., Du, X., Tang, S., Lin, B., Mo, J., Yan, F., Luo, S., Yang, H."Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review)". Molecular and Clinical Oncology 22, no. 3 (2025): 23. https://doi.org/10.3892/mco.2025.2818
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Cheng J, Shi B, Du X, Tang S, Lin B, Mo J, Yan F, Luo S, Yang H, Yang H, et al: Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review). Mol Clin Oncol 22: 23, 2025.
APA
Huang, J., Cheng, J., Shi, B., Du, X., Tang, S., Lin, B. ... Yang, H. (2025). Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review). Molecular and Clinical Oncology, 22, 23. https://doi.org/10.3892/mco.2025.2818
MLA
Huang, J., Cheng, J., Shi, B., Du, X., Tang, S., Lin, B., Mo, J., Yan, F., Luo, S., Yang, H."Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review)". Molecular and Clinical Oncology 22.3 (2025): 23.
Chicago
Huang, J., Cheng, J., Shi, B., Du, X., Tang, S., Lin, B., Mo, J., Yan, F., Luo, S., Yang, H."Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review)". Molecular and Clinical Oncology 22, no. 3 (2025): 23. https://doi.org/10.3892/mco.2025.2818
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