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Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review

  • Authors:
    • Tomonori Yamada
    • Junya Nakajima
    • Yuuki Ooba
    • Akira Yabuno
    • Yuri Yano
    • Masaki Yoshida
    • Mitsutake Yano
    • Masanori Yasuda
    • Eiji Kobayashi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu, Oita 8795593, Japan, Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Oita 8795593, Japan, Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama 3501298, Japan, Department of Medical Oncology and Hematology, Faculty of Medicine, Oita University, Yufu, Oita 8795593, Japan, Department of Diagnostic Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama 3501298, Japan
    Copyright: © Yamada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 27
    |
    Published online on: January 21, 2025
       https://doi.org/10.3892/mco.2025.2822
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Abstract

Bone marrow metastasis (BMM) causes pancytopenia and disseminated intravascular coagulation (DIC), resulting in rapid mortality. The incidence of this disease is likely underestimated, with confirmed BMM occurring at approximately twice the rates expected clinically. The present study describes two detailed cases and includes a literature review of BMM caused by ovarian cancer. The existing medical records of patients admitted to Oita University Hospital (Yufu, Japan) and Saitama Medical University International Medical Center (Hidaka, Japan) were retrospectively analyzed and a literature review regarding BMM associated with ovarian cancer was conducted. The literature review of BMM of ovarian cancer, including the present cases, revealed that patient ages ranged between 37 and 71 years, with tumor histology described in 5 out of 8 cases. Notably, 3 previous cases involved rare histological types (small cell carcinoma, carcinosarcoma and mucinous carcinoid), whereas the present identified cases involved common types. The first case involved a patient who developed isolated BMM/carcinomatosis during maintenance therapy with olaparib for recurrent high‑grade ovarian serous carcinoma. The patient initially presented with elevated cancer antigen 125 levels and decreased blood counts. Following the onset of BMM, the patient's lactate dehydrogenase level was elevated to 2,712 U/l. The second patient was diagnosed with BMM/carcinomatosis, concurrent with an initial diagnosis of ovarian clear cell carcinoma. Both patients subsequently developed pancytopenia and DIC, resulting in mortality. To the best of our knowledge, the present study is the first retrospective study of BMM of ovarian cancer. For early diagnosis, BMM should be considered in the differential diagnosis when a reduction in blood counts is accompanied by an elevation in serum tumor markers, regardless of histological type.
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1 

Deng K, Yang C, Tan Q, Song W, Lu M, Zhao W, Lou G, Li Z, Li K and Hou Y: Sites of distant metastases and overall survival in ovarian cancer: A study of 1481 patients. Gynecol Oncol. 150:460–465. 2018.PubMed/NCBI View Article : Google Scholar

2 

Xiao L, Luxi S, Ying T, Yizhi L, Lingyun W and Quan P: Diagnosis of unknown nonhematological tumors by bone marrow biopsy: A retrospective analysis of 10,112 samples. J Cancer Res Clin Oncol. 135:687–693. 2009.PubMed/NCBI View Article : Google Scholar

3 

Saikia UN, Malhotra P, Khandelwal N, Varma S and Joshi K: Small cell carcinoma of the ovary presenting as bone marrow metastasis: A rare presenting feature. Indian J Pathol Microbiol. 48:402–404. 2005.PubMed/NCBI

4 

Sreenan JJ and Hart WR: Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumors: Further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis. Am J Surg Pathol. 19:666–674. 1995.PubMed/NCBI

5 

Alenghat E, Okagaki T and Talerman A: Primary mucinous carcinoid tumor of the ovary. Cancer. 58:777–783. 1986.PubMed/NCBI View Article : Google Scholar

6 

Ozkalemkas F, Ali R, Ozkocaman V, Ozcelik T, Ozan U, Ozturk H, Kurt E, Evrensel T, Yerci O and Tunali A: The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: A clinical study of 19 cases. BMC Cancer. 5(144)2005.PubMed/NCBI View Article : Google Scholar

7 

Kucukzeybek BB, Calli AO, Kucukzeybek Y, Bener S, Dere Y, Dirican A, Payzin KB, Ozdemirkiran F and Tarhan MO: The prognostic significance of bone marrow metastases: Evaluation of 58 cases. Indian J Pathol Microbiol. 57:396–399. 2014.PubMed/NCBI View Article : Google Scholar

8 

Zhang L, Chen F, Xu L, Li N, Zhuo Q, Guo Y, Wang X, Wen M, Zhao Z and Li M: Comprehensive review of solid tumor bone marrow metastasis. Crit Rev Oncol Hematol. 194(104248)2024.PubMed/NCBI View Article : Google Scholar

9 

Shinden Y, Sugimachi K, Tanaka F, Fujiyoshi K, Kijima Y, Natsugoe S and Mimori K: Clinicopathological characteristics of disseminated carcinomatosis of the bone marrow in breast cancer patients. Mol Clin Oncol. 8:93–98. 2018.PubMed/NCBI View Article : Google Scholar

10 

Kopp HG, Krauss K, Fehm T, Staebler A, Zahm J, Vogel W, Kanz L and Mayer F: Symptomatic bone marrow involvement in breast cancer-clinical presentation, treatment, and prognosis: A single institution review of 22 cases. Anticancer Res. 31:4025–4030. 2011.PubMed/NCBI

11 

Witkowski L, Goudie C, Ramos P, Boshari T, Brunet JS, Karnezis AN, Longy M, Knost JA, Saloustros E, McCluggage WG, et al: The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. Gynecol Oncol. 141:454–460. 2016.PubMed/NCBI View Article : Google Scholar

12 

Kunkel J, Peng Y, Tao Y, Krigman H and Cao D: Presence of a sarcomatous component outside the ovary is an adverse prognostic factor for primary ovarian malignant mixed mesodermal/mullerian tumors: A clinicopathologic study of 47 cases. Am J Surg Pathol. 36:831–837. 2012.PubMed/NCBI View Article : Google Scholar

13 

Baker PM, Oliva E, Young RH, Talerman A and Scully RE: Ovarian mucinous carcinoids including some with a carcinomatous component: A report of 17 cases. Am J Surg Pathol. 25:557–568. 2001.PubMed/NCBI View Article : Google Scholar

14 

Peres LC, Cushing-Haugen KL, Anglesio M, Wicklund K, Bentley R, Berchuck A, Kelemen LE, Nazeran TM, Gilks CB, Harris HR, et al: Histotype classification of ovarian carcinoma: A comparison of approaches. Gynecol Oncol. 151:53–60. 2018.PubMed/NCBI View Article : Google Scholar

15 

Machida H, Matsuo K, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kanauchi M, Nagase S, Enomoto T and Mikami M: Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015: A JSGO-JSOG joint study. Gynecol Oncol. 153:589–596. 2019.PubMed/NCBI View Article : Google Scholar

16 

Al-Ibraheem A, Al-Adhami DA, Abdlkadir AS, Mohamad I, Ghatasheh H and Qandeel M: FDG PET/CT reveals bone marrow oligometastasis in laryngeal squamous carcinoma: A case report with favorable outcome. BJR Case Rep. 9(20230065)2023.PubMed/NCBI View Article : Google Scholar

17 

Chan WK, Lin NS, Tay KV and Teo LT: Systematic review of isolated disseminated carcinomatosis of bone marrow from colorectal cancer. ANZ J Surg. 93:1169–1175. 2023.PubMed/NCBI View Article : Google Scholar

18 

Wang D, Luo Y, Shen D, Yang L, Liu HY and Che YQ: Clinical features and treatment of patients with lung adenocarcinoma with bone marrow metastasis. Tumori. 105:388–393. 2019.PubMed/NCBI View Article : Google Scholar

19 

Bretton PR, Melamed MR, Fair WR and Cote RJ: Detection of occult micrometastases in the bone marrow of patients with prostate carcinoma. Prostate. 25:108–114. 1994.PubMed/NCBI View Article : Google Scholar

20 

Kwon JY, Yun J, Kim HJ, Kim KH, Kim SH, Lee SC, Kim HJ, Bae SB, Kim CK, Lee NS, et al: Clinical outcome of gastric cancer patients with bone marrow metastases. Cancer Res Treat. 43:244–249. 2011.PubMed/NCBI View Article : Google Scholar

21 

Suto H, Inui Y and Okamura A: Long-term survival of a patient with gastric cancer with bone marrow metastasis receiving S-1 plus oxaliplatin beyond three years: A case report and literature review. Front Oncol. 14(1449212)2024.PubMed/NCBI View Article : Google Scholar

22 

Braun S, Vogl FD, Naume B, Janni W, Osborne MP, Coombes RC, Schlimok G, Diel IJ, Gerber B, Gebauer G, et al: A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med. 353:793–802. 2005.PubMed/NCBI View Article : Google Scholar

23 

Hartkopf AD, Brucker SY, Taran FA, Harbeck N, von Au A, Naume B, Pierga JY, Hoffmann O, Beckmann MW, Rydén L, et al: Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis. Eur J Cancer. 154:128–137. 2021.PubMed/NCBI View Article : Google Scholar

24 

Colucci M, Zumerle S, Bressan S, Gianfanti F, Troiani M, Valdata A, D'Ambrosio M, Pasquini E, Varesi A, Cogo F, et al: Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells. Cancer Cell. 42:646–661.e9. 2024.PubMed/NCBI View Article : Google Scholar

25 

Nacarelli T, Fukumoto T, Zundell JA, Fatkhutdinov N, Jean S, Cadungog MG, Borowsky ME and Zhang R: NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer. Cancer Res. 80:890–900. 2020.PubMed/NCBI View Article : Google Scholar

26 

Niu L, Lv H, Zhang M, Zeng H, Fu S, Cui S, Liu Z and Yan M: Clinicopathological features and prognosis of breast cancer combined with symptomatic bone marrow metastases: A 10-year, single-center, real-world study of 67 cases. Cancer Med. 12:10672–10683. 2023.PubMed/NCBI View Article : Google Scholar

27 

Hung YS, Chou WC, Chen TD, Chen TC, Wang PN, Chang H, Hsu HC, Shen WC, Cheng WH and Chen JS: Prognostic factors in adult patients with solid cancers and bone marrow metastases. Asian Pac J Cancer Prev. 15:61–67. 2014.PubMed/NCBI View Article : Google Scholar

28 

Gando S, Levi M and Toh CH: Disseminated intravascular coagulation. Nat Rev Dis Primers. 2(16037)2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yamada T, Nakajima J, Ooba Y, Yabuno A, Yano Y, Yoshida M, Yano M, Yasuda M and Kobayashi E: Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review. Mol Clin Oncol 22: 27, 2025.
APA
Yamada, T., Nakajima, J., Ooba, Y., Yabuno, A., Yano, Y., Yoshida, M. ... Kobayashi, E. (2025). Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review. Molecular and Clinical Oncology, 22, 27. https://doi.org/10.3892/mco.2025.2822
MLA
Yamada, T., Nakajima, J., Ooba, Y., Yabuno, A., Yano, Y., Yoshida, M., Yano, M., Yasuda, M., Kobayashi, E."Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review". Molecular and Clinical Oncology 22.3 (2025): 27.
Chicago
Yamada, T., Nakajima, J., Ooba, Y., Yabuno, A., Yano, Y., Yoshida, M., Yano, M., Yasuda, M., Kobayashi, E."Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review". Molecular and Clinical Oncology 22, no. 3 (2025): 27. https://doi.org/10.3892/mco.2025.2822
Copy and paste a formatted citation
x
Spandidos Publications style
Yamada T, Nakajima J, Ooba Y, Yabuno A, Yano Y, Yoshida M, Yano M, Yasuda M and Kobayashi E: Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review. Mol Clin Oncol 22: 27, 2025.
APA
Yamada, T., Nakajima, J., Ooba, Y., Yabuno, A., Yano, Y., Yoshida, M. ... Kobayashi, E. (2025). Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review. Molecular and Clinical Oncology, 22, 27. https://doi.org/10.3892/mco.2025.2822
MLA
Yamada, T., Nakajima, J., Ooba, Y., Yabuno, A., Yano, Y., Yoshida, M., Yano, M., Yasuda, M., Kobayashi, E."Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review". Molecular and Clinical Oncology 22.3 (2025): 27.
Chicago
Yamada, T., Nakajima, J., Ooba, Y., Yabuno, A., Yano, Y., Yoshida, M., Yano, M., Yasuda, M., Kobayashi, E."Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review". Molecular and Clinical Oncology 22, no. 3 (2025): 27. https://doi.org/10.3892/mco.2025.2822
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