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Review Open Access

Histone crotonylation in tumors (Review)

  • Authors:
    • Xiaoqing Wang
    • Yu Qu
    • Zhaopei Li
    • Qinghua Xia
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    Affiliations: Department of Pediatric Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China, Department of Pediatric Surgery, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, P.R. China, Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China, 6Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 39
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    Published online on: March 11, 2025
       https://doi.org/10.3892/mco.2025.2834
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Abstract

Lysine crotonylation (Kcr) refers to a type of modification in which crotonyl groups are transferred to lysine residues by histone crotonyltransferase (HCT) using crotonyl‑coenzyme A (CoA) as a substrate. Kcr is distributed in core histones and in some nonhistone proteins. Histone crotonylation is a newly discovered epigenetic modification with a significant ability to regulate gene expression. Crotonylation occurs on the ε‑amino group of lysine residues and results in a modification of the histone charge. Similar to acetylation, the substrate for crotonylation is a donor molecule, crotonyl‑CoA, which is linked to the sulfhydryl group of CoA by a thioester bond. Crotonylation is involved in regulating a wide range of biological processes and diseases. With advances in detection technologies, the impact of histone crotonylation on tumors has been revealed. The present review examines the recent discoveries of histone crotonylation, its function in tumors and its regulatory mechanism, which will aid in elucidating the mechanisms of malignant tumor development and provide a theoretical foundation for the development of new targeted cancer therapies.
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1 

Zaib S, Rana N and Khan I: Histone modifications and their role in epigenetics of cancer. Curr Med Chem. 29:2399–2411. 2022.PubMed/NCBI View Article : Google Scholar

2 

Wang M and Lin H: Understanding the function of mammalian sirtuins and protein lysine acylation. Annu Rev Biochem. 90:245–285. 2021.PubMed/NCBI View Article : Google Scholar

3 

Fu Y, Yu J, Li F and Ge S: Oncometabolites drive tumorigenesis by enhancing protein acylation: From chromosomal remodelling to nonhistone modification. J Exp Clin Cancer Res. 41(144)2022.PubMed/NCBI View Article : Google Scholar

4 

Sabari BR, Zhang D, Allis CD and Zhao Y: Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol. 18:90–101. 2017.PubMed/NCBI View Article : Google Scholar

5 

Shvedunova M and Akhtar A: Modulation of cellular processes by histone and non-histone protein acetylation. Nat Rev Mol Cell Biol. 23:329–349. 2022.PubMed/NCBI View Article : Google Scholar

6 

Zhang Y, Sun Z, Jia J, Du T, Zhang N, Tang Y, Fang Y and Fang D: Overview of histone modification. Adv Exp Med Biol. 1283:1–16. 2021.PubMed/NCBI View Article : Google Scholar

7 

Tan M, Luo H, Lee S, Jin F, Yang JS, Montellier E, Buchou T, Cheng Z, Rousseaux S, Rajagopal N, et al: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell. 146:1016–1028. 2011.PubMed/NCBI View Article : Google Scholar

8 

Goudarzi A, Shiota H, Rousseaux S and Khochbin S: Genome-scale acetylation-dependent histone eviction during spermatogenesis. J Mol Biol. 426:3342–3349. 2014.PubMed/NCBI View Article : Google Scholar

9 

Berger K and Moeller MJ: Mechanisms of epithelial repair and regeneration after acute kidney injury. Semin Nephrol. 34:394–403. 2014.PubMed/NCBI View Article : Google Scholar

10 

Liu Y, Li M, Fan M, Song Y, Yu H, Zhi X, Xiao K, Lai S, Zhang J, Jin X, et al: Chromodomain Y-like protein-mediated histone crotonylation regulates stress-induced depressive behaviors. Biol Psychiatry. 85:635–649. 2019.PubMed/NCBI View Article : Google Scholar

11 

Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR III, Hartigan-O'Connor DJ, Margolis DM, et al: HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest. 128:1190–1198. 2018.PubMed/NCBI View Article : Google Scholar

12 

Wan J, Liu H and Ming L: Lysine crotonylation is involved in hepatocellular carcinoma progression. Biomed Pharmacother. 111:976–982. 2019.PubMed/NCBI View Article : Google Scholar

13 

Fellows R, Denizot J, Stellato C, Cuomo A, Jain P, Stoyanova E, Balázsi S, Hajnády Z, Liebert A, Kazakevych J, et al: Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases. Nat Commun. 9(105)2018.PubMed/NCBI View Article : Google Scholar

14 

Hou JY, Cao J, Gao LJ, Zhang FP, Shen J, Zhou L, Shi JY, Feng YL, Yan Z, Wang DP and Cao JM: Upregulation of α enolase (ENO1) crotonylation in colorectal cancer and its promoting effect on cancer cell metastasis. Biochem Biophys Res Commun. 578:77–83. 2021.PubMed/NCBI View Article : Google Scholar

15 

Xu X, Zhu X, Liu F, Lu W, Wang Y and Yu J: The effects of histone crotonylation and bromodomain protein 4 on prostate cancer cell lines. Transl Androl Urol. 10:900–914. 2021.PubMed/NCBI View Article : Google Scholar

16 

Johnson H and Eyers CE: Analysis of post-translational modifications by LC-MS/MS. Methods Mol Biol. 658:93–108. 2010.PubMed/NCBI View Article : Google Scholar

17 

Allfrey VG, Faulkner R and Mirsky AE: Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci USA. 51:786–794. 1964.PubMed/NCBI View Article : Google Scholar

18 

Chen Y, Sprung R, Tang Y, Ball H, Sangras B, Kim SC, Falck JR, Peng J, Gu W and Zhao Y: Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics. 6:812–819. 2007.PubMed/NCBI View Article : Google Scholar

19 

Xie Z, Dai J, Dai L, Tan M, Cheng Z, Wu Y, Boeke JD and Zhao Y: Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics. 11:100–107. 2012.PubMed/NCBI View Article : Google Scholar

20 

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, et al: Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 19:605–617. 2014.PubMed/NCBI View Article : Google Scholar

21 

Dai L, Peng C, Montellier E, Lu Z, Chen Y, Ishii H, Debernardi A, Buchou T, Rousseaux S, Jin F, et al: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. Nat Chem Biol. 10:365–370. 2014.PubMed/NCBI View Article : Google Scholar

22 

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, et al: Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Mol Cell. 62:194–206. 2016.PubMed/NCBI View Article : Google Scholar

23 

Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q and Zhao Y: Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 9(3374)2018.PubMed/NCBI View Article : Google Scholar

24 

Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al: Metabolic regulation of gene expression by histone lactylation. Nature. 574:575–580. 2019.PubMed/NCBI View Article : Google Scholar

25 

Jiang Y, Li Y, Liu C, Zhang L, Lv D, Weng Y, Cheng Z, Chen X, Zhan J and Zhang H: Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid. Nat Commun. 12(5548)2021.PubMed/NCBI View Article : Google Scholar

26 

Xu W, Wan J, Zhan J, Li X, He H, Shi Z and Zhang H: Global profiling of crotonylation on non-histone proteins. Cell Res. 27:946–949. 2017.PubMed/NCBI View Article : Google Scholar

27 

Huang H, Wang DL and Zhao Y: Quantitative crotonylome analysis expands the roles of p300 in the regulation of lysine crotonylation pathway. Proteomics. 18(e1700230)2018.PubMed/NCBI View Article : Google Scholar

28 

Wan J, Liu H, Chu J and Zhang H: Functions and mechanisms of lysine crotonylation. J Cell Mol Med. 23:7163–7169. 2019.PubMed/NCBI View Article : Google Scholar

29 

Ntorla A and Burgoyne JR: The regulation and function of histone crotonylation. Front Cell Dev Biol. 9(624914)2021.PubMed/NCBI View Article : Google Scholar

30 

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, et al: Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. Mol Cell. 58:203–215. 2015.PubMed/NCBI View Article : Google Scholar

31 

Liu X, Wei W, Liu Y, Yang X, Wu J, Zhang Y, Zhang Q, Shi T, Du JX, Zhao Y, et al: MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300. Cell Discov. 3(17016)2017.PubMed/NCBI View Article : Google Scholar

32 

Kollenstart L, de Groot AJL, Janssen GMC, Cheng X, Vreeken K, Martino F, Côté J, van Veelen PA and van Attikum H: Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription. J Biol Chem. 294:20122–20134. 2019.PubMed/NCBI View Article : Google Scholar

33 

Madsen AS and Olsen CA: Profiling of substrates for zinc-dependent lysine deacylase enzymes: HDAC3 exhibits decrotonylase activity in vitro. Angew Chem Int Ed Engl. 51:9083–9087. 2012.PubMed/NCBI View Article : Google Scholar

34 

Bao X, Wang Y, Li X, Li XM, Liu Z, Yang T, Wong CF, Zhang J, Hao Q and Li XD: Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach. Elife. 3(e02999)2014.PubMed/NCBI View Article : Google Scholar

35 

Wei W, Liu X, Chen J, Gao S, Lu L, Zhang H, Ding G, Wang Z, Chen Z, Shi T, et al: Class I histone deacetylases are major histone decrotonylases: Evidence for critical and broad function of histone crotonylation in transcription. Cell Res. 27:898–915. 2017.PubMed/NCBI View Article : Google Scholar

36 

Kelly RDW, Chandru A, Watson PJ, Song Y, Blades M, Robertson NS, Jamieson AG, Schwabe JWR and Cowley SM: Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Sci Rep. 8(14690)2018.PubMed/NCBI View Article : Google Scholar

37 

Zhao S, Zhang X and Li H: Beyond histone acetylation-writing and erasing histone acylations. Curr Opin Struct Biol. 53:169–177. 2018.PubMed/NCBI View Article : Google Scholar

38 

Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD and Kutateladze TG: The Taf14 YEATS domain is a reader of histone crotonylation. Nat Chem Biol. 12:396–398. 2016.PubMed/NCBI View Article : Google Scholar

39 

Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, et al: Molecular Coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol Cell. 62:181–193. 2016.PubMed/NCBI View Article : Google Scholar

40 

Zhao D, Guan H, Zhao S, Mi W, Wen H, Li Y, Zhao Y, Allis CD, Shi X and Li H: YEATS2 is a selective histone crotonylation reader. Cell Res. 26:629–632. 2016.PubMed/NCBI View Article : Google Scholar

41 

Flynn EM, Huang OW, Poy F, Oppikofer M, Bellon SF, Tang Y and Cochran AG: A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications. Structure. 23:1801–1814. 2015.PubMed/NCBI View Article : Google Scholar

42 

Xiong X, Panchenko T, Yang S, Zhao S, Yan P, Zhang W, Xie W, Li Y, Zhao Y, Allis CD and Li H: Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nat Chem Biol. 12:1111–1118. 2016.PubMed/NCBI View Article : Google Scholar

43 

Li Y, Zhang R and Hei H: Advances in post-translational modifications of proteins and cancer immunotherapy. Front Immunol. 14(1229397)2023.PubMed/NCBI View Article : Google Scholar

44 

Li Y and Seto E: HDACs and HDAC inhibitors in cancer development and therapy. Cold Spring Harb Perspect Med. 6(a026831)2016.PubMed/NCBI View Article : Google Scholar

45 

Chen YZ, Wang ZZ, Wang Y, Ying G, Chen Z and Song J: nhKcr: A new bioinformatics tool for predicting crotonylation sites on human nonhistone proteins based on deep learning. Brief Bioinform. 22(bbab146)2021.PubMed/NCBI View Article : Google Scholar

46 

European Association for the Study of the Liver. EASL clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol. 69:182–236. 2018.PubMed/NCBI View Article : Google Scholar

47 

Alawyia B and Constantinou C: Hepatocellular carcinoma: A narrative review on current knowledge and future prospects. Curr Treat Options Oncol. 24:711–724. 2023.PubMed/NCBI View Article : Google Scholar

48 

Zhang D, Tang J, Xu Y, Huang X, Wang Y, Jin X, Wu G and Liu P: Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer. Cell Death Dis. 13(717)2022.PubMed/NCBI View Article : Google Scholar

49 

Zhang XY, Liu ZX, Zhang YF, Xu LX, Chen MK, Zhou YF, Yu J, Li XX and Zhang N: SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival. Cell Biosci. 13(63)2023.PubMed/NCBI View Article : Google Scholar

50 

Liu H, Li D, Zhou L, Kan S, He G, Zhou K, Wang L, Chen M and Shu W: LMNA functions as an oncogene in hepatocellular carcinoma by regulating the proliferation and migration ability. J Cell Mol Med. 24:12008–12019. 2020.PubMed/NCBI View Article : Google Scholar

51 

Zhang Y, Chen Y, Zhang Z, Tao X, Xu S, Zhang X, Zurashvili T, Lu Z, Bayascas JR, Jin L, et al: Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death Dis. 13(279)2022.PubMed/NCBI View Article : Google Scholar

52 

Wirsching HG, Galanis E and Weller M: Glioblastoma. Handb Clin Neurol. 134:381–397. 2016.PubMed/NCBI View Article : Google Scholar

53 

Dai SK, Liu PP, Li X, Jiao LF, Teng ZQ and Liu CM: Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development. Development. 149(dev200049)2022.PubMed/NCBI View Article : Google Scholar

54 

Yuan H, Wu X, Wu Q, Chatoff A, Megill E, Gao J, Huang T, Duan T, Yang K, Jin C, et al: Lysine catabolism reprograms tumour immunity through histone crotonylation. Nature. 617:818–826. 2023.PubMed/NCBI View Article : Google Scholar

55 

Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ and Liu CM: Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Rep. 22(e52023)2021.PubMed/NCBI View Article : Google Scholar

56 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

57 

Molina JR, Yang P, Cassivi SD, Schild SE and Adjei AA: Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 83:584–594. 2008.PubMed/NCBI View Article : Google Scholar

58 

Alexander M, Kim SY and Cheng H: Update 2020: Management of non-small cell lung cancer. Lung. 198:897–907. 2020.PubMed/NCBI View Article : Google Scholar

59 

Wu Q, Li W, Wang C, Fan P, Cao L, Wu Z and Wang F: Ultradeep lysine crotonylome reveals the crotonylation enhancement on both histones and nonhistone proteins by SAHA treatment. J Proteome Res. 16:3664–3671. 2017.PubMed/NCBI View Article : Google Scholar

60 

Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L and Liu X: Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells. Cell Death Dis. 14(645)2023.PubMed/NCBI View Article : Google Scholar

61 

Liao M, Chu W, Sun X, Zheng W, Gao S, Li D and Pei D: Reduction of H3K27cr modification during DNA damage in colon cancer. Front Oncol. 12(924061)2022.PubMed/NCBI View Article : Google Scholar

62 

Liao M, Sun X, Zheng W, Wu M, Wang Y, Yao J, Ma Y, Gao S and Pei D: LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter. Mol Cancer. 22(163)2023.PubMed/NCBI View Article : Google Scholar

63 

Hou JY, Li N, Wang J, Gao LJ, Chang JS and Cao JM: Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer. Epigenetics Chromatin. 16(35)2023.PubMed/NCBI View Article : Google Scholar

64 

Liao P, Bhattarai N, Cao B, Zhou X, Jung JH, Damera K, Fuselier TT, Thareja S, Wimley WC, Wang B, et al: Crotonylation at serine 46 impairs p53 activity. Biochem Biophys Res Commun. 524:730–735. 2020.PubMed/NCBI View Article : Google Scholar

65 

Kusakabe M, Taguchi A, Sone K, Mori M and Osuga Y: Carcinogenesis and management of human papillomavirus-associated cervical cancer. Int J Clin Oncol. 28:965–974. 2023.PubMed/NCBI View Article : Google Scholar

66 

Rahangdale L, Mungo C, O'Connor S, Chibwesha CJ and Brewer NT: Human papillomavirus vaccination and cervical cancer risk. BMJ. 379(e070115)2022.PubMed/NCBI View Article : Google Scholar

67 

Han X, Xiang X, Yang H, Zhang H, Liang S, Wei J and Yu J: p300-catalyzed lysine crotonylation promotes the proliferation, invasion, and migration of HeLa cells via heterogeneous nuclear ribonucleoprotein A1. Anal Cell Pathol (Amst). 2020(5632342)2020.PubMed/NCBI View Article : Google Scholar

68 

Yu H, Bu C, Liu Y, Gong T, Liu X, Liu S, Peng X, Zhang W, Peng Y, Yang J, et al: Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination-mediated DNA repair. Sci Adv. 6(eaay4697)2020.PubMed/NCBI View Article : Google Scholar

69 

Kuhlmann N, Chollet C, Baldus L, Neundorf I and Lammers M: Development of substrate-derived sirtuin inhibitors with potential anticancer activity. ChemMedChem. 12:1703–1714. 2017.PubMed/NCBI View Article : Google Scholar

70 

Xu LX, Hao LJ, Ma JQ, Liu JK and Hasim A: SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. Mol Cell Biochem. 464:11–20. 2020.PubMed/NCBI View Article : Google Scholar

71 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE and Grandis JR: Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 6(92)2020.PubMed/NCBI View Article : Google Scholar

72 

Jiang L, Yin X, Zhang H, Zhang X, Cao Z, Zhou M and Xu W: Development and validation of a prognostic signature based on the lysine crotonylation regulators in head and neck squamous cell carcinoma. Biomed Res Int. 2023(4444869)2023.PubMed/NCBI View Article : Google Scholar

73 

Cai LY, Chen SJ, Xiao SH, Sun QJ, Ding CH, Zheng BN, Zhu XY, Liu SQ, Yang F, Yang YX, et al: Targeting p300/CBP attenuates hepatocellular carcinoma progression through epigenetic regulation of metabolism. Cancer Res. 81:860–872. 2021.PubMed/NCBI View Article : Google Scholar

74 

Lao Y, Cui X, Xu Z, Yan H, Zhang Z, Zhang Z, Geng L, Li B, Lu Y, Guan Q, et al: Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma. J Hepatol. 81:847–861. 2024.PubMed/NCBI View Article : Google Scholar

75 

Zeng Z, Lei S, He Z, Chen T and Jiang J: YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration. J Cell Physiol. 236:2087–2098. 2021.PubMed/NCBI View Article : Google Scholar

76 

Listunov D, Linhares BM, Kim E, Winkler A, Simes ML, Weaver S, Cho HJ, Rizo A, Zolov S, Keshamouni VG, et al: Development of potent dimeric inhibitors of GAS41 YEATS domain. Cell Chem Biol. 28:1716–1727.e6. 2021.PubMed/NCBI View Article : Google Scholar

77 

Ma XR, Xu L, Xu S, Klein BJ, Wang H, Das S, Li K, Yang KS, Sohail S, Chapman A, et al: Discovery of selective small-molecule inhibitors for the ENL YEATS domain. J Med Chem. 64:10997–11013. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Qu Y, Li Z and Xia Q: Histone crotonylation in tumors (Review). Mol Clin Oncol 22: 39, 2025.
APA
Wang, X., Qu, Y., Li, Z., & Xia, Q. (2025). Histone crotonylation in tumors (Review). Molecular and Clinical Oncology, 22, 39. https://doi.org/10.3892/mco.2025.2834
MLA
Wang, X., Qu, Y., Li, Z., Xia, Q."Histone crotonylation in tumors (Review)". Molecular and Clinical Oncology 22.5 (2025): 39.
Chicago
Wang, X., Qu, Y., Li, Z., Xia, Q."Histone crotonylation in tumors (Review)". Molecular and Clinical Oncology 22, no. 5 (2025): 39. https://doi.org/10.3892/mco.2025.2834
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Qu Y, Li Z and Xia Q: Histone crotonylation in tumors (Review). Mol Clin Oncol 22: 39, 2025.
APA
Wang, X., Qu, Y., Li, Z., & Xia, Q. (2025). Histone crotonylation in tumors (Review). Molecular and Clinical Oncology, 22, 39. https://doi.org/10.3892/mco.2025.2834
MLA
Wang, X., Qu, Y., Li, Z., Xia, Q."Histone crotonylation in tumors (Review)". Molecular and Clinical Oncology 22.5 (2025): 39.
Chicago
Wang, X., Qu, Y., Li, Z., Xia, Q."Histone crotonylation in tumors (Review)". Molecular and Clinical Oncology 22, no. 5 (2025): 39. https://doi.org/10.3892/mco.2025.2834
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