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Case Report Open Access

Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review

  • Authors:
    • Hitoshi Miyashita
    • Masaki Sugazaki
    • Haruka Saito
    • Chieko Kudo
    • Munenori Nagao
    • Yojiro Ishikawa
    • Satoshi Teramura
    • Fumiaki Shinohara
    • Kazuhiro Murakami
  • View Affiliations / Copyright

    Affiliations: Department of Dentistry and Oral Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983‑8512, Japan, Department of Pathology, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983‑8512, Japan, Department of Medical Oncology, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983‑8512, Japan, Department of Supportive Medicine and Care for Cancer, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983‑8512, Japan, Department of Radiology, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983‑8512, Japan
    Copyright: © Miyashita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 41
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    Published online on: March 11, 2025
       https://doi.org/10.3892/mco.2025.2836
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Abstract

Gastric cancer metastasizing to the gingiva is rare. The present study reports a case of maxillary gingival metastasis arising from gastric cancer treated with chemotherapy, surgical excision and radiotherapy. A 55‑year‑old male, who received chemotherapy with trifluridine/tipiracil for treatment of refractory gastric cancer with multiple metastasis, was admitted to the Department of Dentistry and Oral Surgery, Tohoku Medical and Pharmaceutical University Hospital (Sendai, Japan) in December 2023 because of the right side of the maxillary gingival mass presenting with protruding growth. The size of the tumor was ~20 mm. Tumor excision was performed followed by histopathological diagnosis which revealed a metastatic gingival tumor originating from gastric adenocarcinoma. Consequently, the patient underwent a palliative Radiation Therapy Oncology Group 8502 ‘QUAD shot’ regimen. Although there was no progression of oral lesion, the patient died 3 months after diagnosis of gingival metastasis. The present study reviewed previous case records of gingival metastasis originating from gastric cancer and summarized treatment modalities along with clinicopathological association. In conclusion, the prognosis of patients with metastases to the oral region (MOR) is usually unfavorable. For the management of MOR, a multidisciplinary team approach is necessary to develop appropriate treatment strategies. If there are possibilities to improve prognosis or quality of life, the consideration of combination therapy with radical or palliative intent is warranted.
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Copy and paste a formatted citation
Spandidos Publications style
Miyashita H, Sugazaki M, Saito H, Kudo C, Nagao M, Ishikawa Y, Teramura S, Shinohara F and Murakami K: Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review. Mol Clin Oncol 22: 41, 2025.
APA
Miyashita, H., Sugazaki, M., Saito, H., Kudo, C., Nagao, M., Ishikawa, Y. ... Murakami, K. (2025). Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 22, 41. https://doi.org/10.3892/mco.2025.2836
MLA
Miyashita, H., Sugazaki, M., Saito, H., Kudo, C., Nagao, M., Ishikawa, Y., Teramura, S., Shinohara, F., Murakami, K."Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 22.5 (2025): 41.
Chicago
Miyashita, H., Sugazaki, M., Saito, H., Kudo, C., Nagao, M., Ishikawa, Y., Teramura, S., Shinohara, F., Murakami, K."Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 22, no. 5 (2025): 41. https://doi.org/10.3892/mco.2025.2836
Copy and paste a formatted citation
x
Spandidos Publications style
Miyashita H, Sugazaki M, Saito H, Kudo C, Nagao M, Ishikawa Y, Teramura S, Shinohara F and Murakami K: Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review. Mol Clin Oncol 22: 41, 2025.
APA
Miyashita, H., Sugazaki, M., Saito, H., Kudo, C., Nagao, M., Ishikawa, Y. ... Murakami, K. (2025). Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 22, 41. https://doi.org/10.3892/mco.2025.2836
MLA
Miyashita, H., Sugazaki, M., Saito, H., Kudo, C., Nagao, M., Ishikawa, Y., Teramura, S., Shinohara, F., Murakami, K."Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 22.5 (2025): 41.
Chicago
Miyashita, H., Sugazaki, M., Saito, H., Kudo, C., Nagao, M., Ishikawa, Y., Teramura, S., Shinohara, F., Murakami, K."Treatment strategy for maxillary gingival metastasis arising from gastric adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 22, no. 5 (2025): 41. https://doi.org/10.3892/mco.2025.2836
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