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Review Open Access

Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review)

  • Authors:
    • Zeming Wang
    • Guoying Cai
    • Junquan Zhu
    • Juchao Wang
    • Yufeng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Integrative Medicine and Medical Oncology, Shengzhou People's Hospital (Shengzhou Branch of The First Affiliated Hospital of Zhejiang University School of Medicine, Shengzhou Hospital of Shaoxing University), Shengzhou, Zhejiang 312400, P.R. China, Department of Oncology Radiotherapy, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Shaoxing, Zhejiang 311800, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: March 12, 2025
       https://doi.org/10.3892/mco.2025.2837
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Abstract

Before the twentieth century, patients with advanced lung cancer had limited treatment options and chemotherapy was the primary form of treatment, with an overall survival often <0.5 years. However, with advances in society and medical technology, the treatment approaches for advanced non‑small cell lung cancer (NSCLC) have markedly changed. Traditional chemotherapy has been gradually replaced by targeted therapy and immunotherapy, leading to the emergence of various new therapeutic options that offer patients more personalized and precise care. This raises the question of what the future holds for the treatment of NSCLC. This review provides a comprehensive analysis of the latest breakthroughs in targeted therapies, immunotherapies, and drugs for antibody‑drug conjugates (ADCs), highlights advances in multimodal combination therapy strategies, and explores the causes of resistance and the challenges that exist in overcoming it. In particular, this review provides unique insights into key directions for future research in NSCLC, such as personalised treatment strategies and biomarker exploration based on multi‑omics data, aiming to provide new inspiration for clinical decision‑making and research.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Cai G, Zhu J, Wang J and Zhang Y: Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review). Mol Clin Oncol 22: 42, 2025.
APA
Wang, Z., Cai, G., Zhu, J., Wang, J., & Zhang, Y. (2025). Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review). Molecular and Clinical Oncology, 22, 42. https://doi.org/10.3892/mco.2025.2837
MLA
Wang, Z., Cai, G., Zhu, J., Wang, J., Zhang, Y."Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review)". Molecular and Clinical Oncology 22.5 (2025): 42.
Chicago
Wang, Z., Cai, G., Zhu, J., Wang, J., Zhang, Y."Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review)". Molecular and Clinical Oncology 22, no. 5 (2025): 42. https://doi.org/10.3892/mco.2025.2837
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Cai G, Zhu J, Wang J and Zhang Y: Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review). Mol Clin Oncol 22: 42, 2025.
APA
Wang, Z., Cai, G., Zhu, J., Wang, J., & Zhang, Y. (2025). Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review). Molecular and Clinical Oncology, 22, 42. https://doi.org/10.3892/mco.2025.2837
MLA
Wang, Z., Cai, G., Zhu, J., Wang, J., Zhang, Y."Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review)". Molecular and Clinical Oncology 22.5 (2025): 42.
Chicago
Wang, Z., Cai, G., Zhu, J., Wang, J., Zhang, Y."Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review)". Molecular and Clinical Oncology 22, no. 5 (2025): 42. https://doi.org/10.3892/mco.2025.2837
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