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Review Open Access

Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review)

  • Authors:
    • Lijun Wang
    • Zichao Xu
    • Mengqi Sun
    • Hongwen He
    • Zihuang Li
  • View Affiliations / Copyright

    Affiliations: Department of Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong 523000, P.R. China, Department of The Second Clinical Medical College of Jinan University, Department of Radiation Therapy, Shenzhen People's Hospital, Shenzhen, Guangdong 518000, P.R. China, Department of The Second Clinical Medical College of Jinan University, Department of Radiation Therapy, Shenzhen People's Hospital, Shenzhen, Guangdong 518000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
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    Published online on: April 3, 2025
       https://doi.org/10.3892/mco.2025.2845
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Abstract

Treatment options for unresectable locally advanced esophageal squamous cell carcinoma (ESCC) are limited. Currently, radical concurrent chemoradiotherapy is recommended as the standard treatment at home and abroad, but its local control rate and overall survival are not satisfactory. Previously, the expected therapeutic effect was not achieved by optimizing radiotherapy and chemotherapy regimens. Significant progress has been made in the efficacy of immune checkpoint inhibitors (ICIs) in treating patients with advanced and resectable locally advanced ESCC, and clinical trials of ICIs for unresectable locally advanced ESCC are underway. Based on the existing literature, the present review discusses the current status and prospects of treating unresectable locally advanced ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Xu Z, Sun M, He H and Li Z: Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review). Mol Clin Oncol 22: 50, 2025.
APA
Wang, L., Xu, Z., Sun, M., He, H., & Li, Z. (2025). Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review). Molecular and Clinical Oncology, 22, 50. https://doi.org/10.3892/mco.2025.2845
MLA
Wang, L., Xu, Z., Sun, M., He, H., Li, Z."Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review)". Molecular and Clinical Oncology 22.6 (2025): 50.
Chicago
Wang, L., Xu, Z., Sun, M., He, H., Li, Z."Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review)". Molecular and Clinical Oncology 22, no. 6 (2025): 50. https://doi.org/10.3892/mco.2025.2845
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Xu Z, Sun M, He H and Li Z: Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review). Mol Clin Oncol 22: 50, 2025.
APA
Wang, L., Xu, Z., Sun, M., He, H., & Li, Z. (2025). Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review). Molecular and Clinical Oncology, 22, 50. https://doi.org/10.3892/mco.2025.2845
MLA
Wang, L., Xu, Z., Sun, M., He, H., Li, Z."Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review)". Molecular and Clinical Oncology 22.6 (2025): 50.
Chicago
Wang, L., Xu, Z., Sun, M., He, H., Li, Z."Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review)". Molecular and Clinical Oncology 22, no. 6 (2025): 50. https://doi.org/10.3892/mco.2025.2845
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