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Review Open Access

Impact of gut microbiota on colorectal anastomotic healing (Review)

  • Authors:
    • Yangyang Chen
    • Nian Wu
    • Xin Yan
    • Liping Kang
    • Guoyong Ou
    • Zhenlin Zhou
    • Changbo Xu
    • Jiayi Feng
    • Tou Shi
  • View Affiliations / Copyright

    Affiliations: General Surgery Department, Guiyang Public Health Clinical Center, Guiyang, Guizhou 550004, P.R. China, Clinical Medical College, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Anesthesia Operating Room, Guiyang Public Health Clinical Center, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: April 14, 2025
       https://doi.org/10.3892/mco.2025.2847
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Abstract

Intestinal anastomosis is a critical procedure in both emergency and elective surgeries to maintain intestinal continuity. However, the incidence of anastomotic leakage (AL) has recently increased, reaching up to 20%, imposing major clinical and economic burdens. Substantial perioperative alterations in the intestinal microbiota composition may contribute to AL, particularly due to disruptions in key microbial populations essential for intestinal health and healing. The intricate interplay between the intestinal microbiota and the host immune system, along with microbial changes before and during surgery, significantly influences anastomotic integrity. Notably, specific pathogens such as Enterococcus and Pseudomonas aeruginosa have been implicated in AL pathogenesis. Preventive strategies including dietary regulation, personalized intestinal preparation, microbiota restoration and enhanced recovery after surgery protocols, may mitigate AL risks. Future research should focus on elucidating the precise mechanisms linking intestinal microbiota alterations to anastomotic healing and developing targeted interventions to improve surgical outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Wu N, Yan X, Kang L, Ou G, Zhou Z, Xu C, Feng J and Shi T: Impact of gut microbiota on colorectal anastomotic healing (Review). Mol Clin Oncol 22: 52, 2025.
APA
Chen, Y., Wu, N., Yan, X., Kang, L., Ou, G., Zhou, Z. ... Shi, T. (2025). Impact of gut microbiota on colorectal anastomotic healing (Review). Molecular and Clinical Oncology, 22, 52. https://doi.org/10.3892/mco.2025.2847
MLA
Chen, Y., Wu, N., Yan, X., Kang, L., Ou, G., Zhou, Z., Xu, C., Feng, J., Shi, T."Impact of gut microbiota on colorectal anastomotic healing (Review)". Molecular and Clinical Oncology 22.6 (2025): 52.
Chicago
Chen, Y., Wu, N., Yan, X., Kang, L., Ou, G., Zhou, Z., Xu, C., Feng, J., Shi, T."Impact of gut microbiota on colorectal anastomotic healing (Review)". Molecular and Clinical Oncology 22, no. 6 (2025): 52. https://doi.org/10.3892/mco.2025.2847
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Wu N, Yan X, Kang L, Ou G, Zhou Z, Xu C, Feng J and Shi T: Impact of gut microbiota on colorectal anastomotic healing (Review). Mol Clin Oncol 22: 52, 2025.
APA
Chen, Y., Wu, N., Yan, X., Kang, L., Ou, G., Zhou, Z. ... Shi, T. (2025). Impact of gut microbiota on colorectal anastomotic healing (Review). Molecular and Clinical Oncology, 22, 52. https://doi.org/10.3892/mco.2025.2847
MLA
Chen, Y., Wu, N., Yan, X., Kang, L., Ou, G., Zhou, Z., Xu, C., Feng, J., Shi, T."Impact of gut microbiota on colorectal anastomotic healing (Review)". Molecular and Clinical Oncology 22.6 (2025): 52.
Chicago
Chen, Y., Wu, N., Yan, X., Kang, L., Ou, G., Zhou, Z., Xu, C., Feng, J., Shi, T."Impact of gut microbiota on colorectal anastomotic healing (Review)". Molecular and Clinical Oncology 22, no. 6 (2025): 52. https://doi.org/10.3892/mco.2025.2847
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