Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2025 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma

  • Authors:
    • Xing Liu
    • Kaiyuan Chang
    • Jian Liu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The Second People's Hospital of Futian District Shenzhen, Shenzhen, Guangdong 518049, P.R. China, Department of Laboratory Medicine, Longhua District Central Hospital, Shenzhen, Guangdong 518100, P.R. China, Department of Emergency, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 65
    |
    Published online on: May 22, 2025
       https://doi.org/10.3892/mco.2025.2860
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the expression of cyclin‑dependent kinase inhibitor 3 (CDKN3) as well as its clinical value in hepatocellular carcinoma (HCC) using bioinformatic analysis. The expression of CDKN3 in HCC and its correlation with HCC prognosis were analyzed using the UALCAN and SangerBox databases. The findings obtained from the UALCAN database were validated using immunohistochemistry. The Assistant for Clinical Bioinformatics database was employed for the unifactorial and multifactorial analyses regarding the correlation between CDKN3 and pathways, and the STRING database served for the correlation analysis between CDKN3 and proteins. The results revealed that CDKN3 expression increases in tumor tissues and corresponds with an increase in the tumor stage. CDKN3 crucially affects prognosis of patients with HCC and is an essential factor for the diagnosis and prognosis of this condition. CDKN3 expression in HCC is mainly related to pathways for DNA repair, fatty acid degradation, G2M checkpoints, MYC targets, selenium compound metabolism and tumor proliferation. The role of CDKN3 in HCC was found to be related to genes including PTTG2, BIRC5, CKS2, CCNB2 and CCNA2. In conclusion, CDKN3 exhibits a high expression in HCC tumor tissues, and such expression substantially affects tumor patients' prognosis. The role of CDKN3 role in HCC is closely related to cell cycle‑related pathways, showing its potential as a therapeutic target for HCC and as an indicator for the determination of prognosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

View References

1 

Shi JF, Cao M, Wang Y, Bai FZ, Lei L, Peng J, Feletto E, Canfell K, Qu C and Chen W: Is it possible to halve the incidence of liver cancer in China by 2050? Int J Cancer. 148:1051–1065. 2021.PubMed/NCBI View Article : Google Scholar

2 

Xia Y, Li J, Liu G, Wang K, Qian G, Lu Z, Yang T, Yan Z, Lei Z, Si A, et al: Long-term effects of repeat hepatectomy vs percutaneous radiofrequency ablation among patients with recurrent hepatocellular carcinoma: A randomized clinical trial. JAMA Oncol. 6:255–263. 2020.PubMed/NCBI View Article : Google Scholar

3 

Ding J and Wen Z: Survival improvement and prognosis for hepatocellular carcinoma: Analysis of the SEER database. BMC Cancer. 21(1157)2021.PubMed/NCBI View Article : Google Scholar

4 

Zhang C, Shen Q, Gao M, Li J and Pang B: The role of cyclin dependent kinase inhibitor 3 (CDKN3) in promoting human tumors: Literature review and pan-cancer analysis. Heliyon. 10(e26061)2024.PubMed/NCBI View Article : Google Scholar

5 

Barrón EV, Roman-Bassaure E, Sánchez-Sandoval AL, Espinosa AM, Guardado-Estrada M, Medina I, Juárez E, Alfaro A, Bermúdez M, Zamora R, et al: CDKN3 mRNA as a biomarker for survival and therapeutic target in cervical cancer. PLoS One. 10(e0137397)2015.PubMed/NCBI View Article : Google Scholar

6 

Li WH, Zhang L and Wu YH: CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1. Eur Rev Med Pharmacol Sci. 24:3614–3623. 2020.PubMed/NCBI View Article : Google Scholar

7 

Dai W, Miao H, Fang S, Fang T, Chen N and Li M: CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma. Mol Med Rep. 14:1509–1514. 2016.PubMed/NCBI View Article : Google Scholar

8 

Huang R, Guo L, Chen C, Xiang Y, Li G, Zheng J, Wu Y, Yuan X, Zhou J, Gao W and Xiang S: System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma. PLoS One. 18(e0289418)2023.PubMed/NCBI View Article : Google Scholar

9 

Shi T, Hu Z, Tian L and Yang Y: Pan-cancer landscape of CENPO and its underlying mechanism in LUAD. Respir Res. 24(113)2023.PubMed/NCBI View Article : Google Scholar

10 

Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, et al: The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51:D638–D646. 2023.PubMed/NCBI View Article : Google Scholar

11 

Gao J, Yang S, Xie G, Pan J and Zhu F: Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of Aloin against gastric cancer. Drug Des Devel The. 16:1947–1961. 2022.PubMed/NCBI View Article : Google Scholar

12 

Hu J, Qiu D, Yu A, Hu J, Deng H, Li H, Yi Z, Chen J and Zu X: YTHDF1 Is a potential pan-cancer biomarker for prognosis and immunotherapy. Front Oncol. 11(607224)2021.PubMed/NCBI View Article : Google Scholar

13 

Hou W, Kong L, Hou Z and Ji H: CD44 is a prognostic biomarker and correlated with immune infiltrates in gastric cancer. BMC Med Genomics. 15(225)2022.PubMed/NCBI View Article : Google Scholar

14 

Xie D, Shi J, Zhou J, Fan J and Gao Q: Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Chinese perspective. Clin Mol Hepatol. 29:206–216. 2023.PubMed/NCBI View Article : Google Scholar

15 

An L, Zeng HM, Zheng RS, Zhang SW, Sun KX, Zou XN, Chen R, Wang SM, Gu XY, Wei WW and He J: Liver cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi. 41:721–727. 2019.PubMed/NCBI View Article : Google Scholar

16 

Mori J, Sawada T, Baba T, Hayakawa A, Kanemoto Y, Nishimura K, Amano R, Siril YJ, Okada M, Kurokawa T and Kato S: Identification of cell cycle-associated and -unassociated regulators for expression of a hepatocellular carcinoma oncogene cyclin-dependent kinase inhibitor 3. Biochem Biophys Res Commun. 625:46–52. 2022.PubMed/NCBI View Article : Google Scholar

17 

Deng X, Ma J, Zhou W, Yuan Y, Wang B and Meng X: GID2 interacts with CDKN3 and regulates pancreatic cancer growth and apoptosis. Lab Invest. 103(100122)2023.PubMed/NCBI View Article : Google Scholar

18 

Gao C, Fan X, Liu Y, Han Y, Liu S, Li H, Zhang Q, Wang Y and Xue F: Comprehensive analysis reveals the potential roles of CDKN3 in pancancer and verification in endometrial cancer. Int J Gen Med. 16:5817–5839. 2023.PubMed/NCBI View Article : Google Scholar

19 

Ghafouri-Fard S, Khoshbakht T, Hussen BM, Dong P, Gassler N, Taheri M, Baniahmad A and Dilmaghani NA: A review on the role of cyclin dependent kinases in cancers. Cancer Cell Int. 22(325)2022.PubMed/NCBI View Article : Google Scholar

20 

Yu C, Cao H, He X, Sun P, Feng Y, Chen L and Gong H: Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Biomed Pharmacother. 96:1109–1118. 2017.PubMed/NCBI View Article : Google Scholar

21 

Zhang J, Zhang Y and Zhang J: N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelial-mesenchymal transition via CDKN3 in endometrial cancer. Cell Mol Biol (Noisy-le-grand). 70:161–169. 2024.PubMed/NCBI View Article : Google Scholar

22 

Al Sharie AH, Abu Zahra AM, El-Elimat T, Darweesh RF, Al-Khaldi AK, Abu Mousa BM, Amer MSB, Al Zu'bi YO, Al-Kammash K, Abu Lil A, et al: Cyclin dependent kinase inhibitor 3 (CDKN3) upregulation is associated with unfavorable prognosis in clear cell renal cell carcinoma and shapes tumor immune microenvironment: A bioinformatics analysis. Medicine (Baltimore). 102(e35004)2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu X, Chang K and Liu J: Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma. Mol Clin Oncol 23: 65, 2025.
APA
Liu, X., Chang, K., & Liu, J. (2025). Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma. Molecular and Clinical Oncology, 23, 65. https://doi.org/10.3892/mco.2025.2860
MLA
Liu, X., Chang, K., Liu, J."Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma". Molecular and Clinical Oncology 23.1 (2025): 65.
Chicago
Liu, X., Chang, K., Liu, J."Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma". Molecular and Clinical Oncology 23, no. 1 (2025): 65. https://doi.org/10.3892/mco.2025.2860
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Chang K and Liu J: Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma. Mol Clin Oncol 23: 65, 2025.
APA
Liu, X., Chang, K., & Liu, J. (2025). Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma. Molecular and Clinical Oncology, 23, 65. https://doi.org/10.3892/mco.2025.2860
MLA
Liu, X., Chang, K., Liu, J."Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma". Molecular and Clinical Oncology 23.1 (2025): 65.
Chicago
Liu, X., Chang, K., Liu, J."Clinical significance of cyclin‑dependent kinase inhibitor 3 in hepatocellular carcinoma". Molecular and Clinical Oncology 23, no. 1 (2025): 65. https://doi.org/10.3892/mco.2025.2860
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team