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Review Special Issue Open Access

Role of TERT gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review)

This article is part of the special Issue: Thyroid Cancer
  • Authors:
    • Abdul-Mohsen G. Alhejaily
    • Omar Alhuzaim
    • Naji Aljohani
    • Doaa Alghamdi
    • Raneem O. Salem
  • View Affiliations / Copyright

    Affiliations: Academic Operations Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh 11525, Kingdom of Saudi Arabia, Obesity, Endocrine and Metabolism Center, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh 11525, Kingdom of Saudi Arabia, Anatomical Pathology Department, Pathology Department, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh 11525, Kingdom of Saudi Arabia
    Copyright: © Alhejaily et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
    |
    Published online on: June 26, 2025
       https://doi.org/10.3892/mco.2025.2869
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Abstract

The present review provides a comprehensive analysis of the significance of telomerase reverse transcriptase (TERT) promoter mutations in the progression of anaplastic thyroid cancer (ATC). The significance of these mutations lies in their role in reactivating telomerase, and when combined with BRAF and RAS mutations, they contribute to heightened aggressiveness in ATC. The clinical implications of TERT promoter mutations were discussed, evaluating their potential role as prognostic biomarkers and targets for therapeutic intervention. The present review also emphasizes recent developments in our comprehension of TERT's role in the progression of ATC, offering insights that may guide future investigations focused on improving patient management for this condition.
View Figures

Figure 1

Mutant TERT promoter, which is found
in the majority of anaplastic thyroid cancer cells. (A) Normal
cells that do not express TERT shorten their telomeres
progressively with each cellular division. (B) By contrast, in
tumor cells with TERT promoter mutations, TERT is activated, and
telomeres are maintained, facilitating cellular immortality. The
figure generated by Microsoft® PowerPoint (version
16.9.3; Microsoft Corporation). TERT, telomerase reverse
transcriptase; WT, wild-type.
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Copy and paste a formatted citation
Spandidos Publications style
Alhejaily AG, Alhuzaim O, Aljohani N, Alghamdi D and Salem RO: Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review). Mol Clin Oncol 23: 74, 2025.
APA
Alhejaily, A.G., Alhuzaim, O., Aljohani, N., Alghamdi, D., & Salem, R.O. (2025). Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review). Molecular and Clinical Oncology, 23, 74. https://doi.org/10.3892/mco.2025.2869
MLA
Alhejaily, A. G., Alhuzaim, O., Aljohani, N., Alghamdi, D., Salem, R. O."Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review)". Molecular and Clinical Oncology 23.2 (2025): 74.
Chicago
Alhejaily, A. G., Alhuzaim, O., Aljohani, N., Alghamdi, D., Salem, R. O."Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review)". Molecular and Clinical Oncology 23, no. 2 (2025): 74. https://doi.org/10.3892/mco.2025.2869
Copy and paste a formatted citation
x
Spandidos Publications style
Alhejaily AG, Alhuzaim O, Aljohani N, Alghamdi D and Salem RO: Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review). Mol Clin Oncol 23: 74, 2025.
APA
Alhejaily, A.G., Alhuzaim, O., Aljohani, N., Alghamdi, D., & Salem, R.O. (2025). Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review). Molecular and Clinical Oncology, 23, 74. https://doi.org/10.3892/mco.2025.2869
MLA
Alhejaily, A. G., Alhuzaim, O., Aljohani, N., Alghamdi, D., Salem, R. O."Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review)". Molecular and Clinical Oncology 23.2 (2025): 74.
Chicago
Alhejaily, A. G., Alhuzaim, O., Aljohani, N., Alghamdi, D., Salem, R. O."Role of <em>TERT</em> gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review)". Molecular and Clinical Oncology 23, no. 2 (2025): 74. https://doi.org/10.3892/mco.2025.2869
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