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Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series

  • Authors:
    • Xiaojing Zhao
    • Chaoyi Yuan
    • Xinrun Wang
    • Yang Liu
    • Xiaojing Li
    • Zhongna Yu
    • Liang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 98
    |
    Published online on: September 10, 2025
       https://doi.org/10.3892/mco.2025.2893
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Abstract

Serous papillary adenofibroma (SPAF) is a rare benign tumor in gynecological practice. Most patients have no symptoms and occasionally present with pelvic masses during physical examinations. SPAF consists of both fibrous and epithelial parts, which makes it easy to misdiagnose malignancies on pre‑surgery examinations. Therefore, clinical and pathological features of SPAF at the Second Affiliated Hospital Zhejiang University School of Medicine (Hangzhou, China) were summarized in the present study to assist clinical practice. A total of 13 cases encountered at our hospital were collected and immunohistochemistry (IHC) staining was performed on their specimens. SPAF appears as a unilocular cystic mass on imaging. Serum estradiol and prolactin levels were elevated in certain patients. The IHC staining of SPAF was estrogen receptor‑, progesterone receptor‑ and human epidermal growth factor receptor 2‑positive but Ki‑67‑ and p53‑negative. The present study proved the sex hormone sensitivity of SPAF and the benign prognosis of patients. Magnetic resonance imaging is a promising method for differential diagnosis before surgery.
View Figures

Figure 1

Gross appearance of SPAF during
surgery. The images (A and B) are from a 26-year-old female
patient. (A) Gross appearance before resection; a string of cysts
can be seen on the surface of the ovary. (B) Gross appearance after
resection; typical SPAF had multiple cysts with a solid part. LFT,
left fallopian tube; LO, left ovary; S, solid part; C, cysts; SPAF,
serous papillary adenofibroma.

Figure 2

Typical ultrasound image of papillae.
The white arrow indicates papillae of serous papillary
adenofibroma.

Figure 3

Magnetic resonance imaging appearance
of serous papillary adenofibroma in various phases. (A) Transverse
section in apparent diffusion coefficient phase. (B) Transverse
section in diffusion-weighted imaging phase. (C) Transverse section
in T2 phase. (D) Sagittal plane in T2 phase. (E) Transverse section
in T2 phase with enhancement from one slice level (red rectangle
shows spotted protrusion that is likely to be papillae). (F)
Transverse section in T2 phase with enhancement from another slice
level (red rectangle shows another spotted protrusion that is
likely to be papillae).

Figure 4

Representative immunohistochemistry
images. Strong positivity was encountered for (A) estrogen
receptor, (B) progesterone receptor and (C) human epidermal growth
factor receptor 2. The right-hand panel shows magnified windows
from the left-hand panel (scale bars, 50 µm).
View References

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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Yuan C, Wang X, Liu Y, Li X, Yu Z and Wang L: Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series. Mol Clin Oncol 23: 98, 2025.
APA
Zhao, X., Yuan, C., Wang, X., Liu, Y., Li, X., Yu, Z., & Wang, L. (2025). Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series. Molecular and Clinical Oncology, 23, 98. https://doi.org/10.3892/mco.2025.2893
MLA
Zhao, X., Yuan, C., Wang, X., Liu, Y., Li, X., Yu, Z., Wang, L."Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series". Molecular and Clinical Oncology 23.5 (2025): 98.
Chicago
Zhao, X., Yuan, C., Wang, X., Liu, Y., Li, X., Yu, Z., Wang, L."Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series". Molecular and Clinical Oncology 23, no. 5 (2025): 98. https://doi.org/10.3892/mco.2025.2893
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Yuan C, Wang X, Liu Y, Li X, Yu Z and Wang L: Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series. Mol Clin Oncol 23: 98, 2025.
APA
Zhao, X., Yuan, C., Wang, X., Liu, Y., Li, X., Yu, Z., & Wang, L. (2025). Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series. Molecular and Clinical Oncology, 23, 98. https://doi.org/10.3892/mco.2025.2893
MLA
Zhao, X., Yuan, C., Wang, X., Liu, Y., Li, X., Yu, Z., Wang, L."Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series". Molecular and Clinical Oncology 23.5 (2025): 98.
Chicago
Zhao, X., Yuan, C., Wang, X., Liu, Y., Li, X., Yu, Z., Wang, L."Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series". Molecular and Clinical Oncology 23, no. 5 (2025): 98. https://doi.org/10.3892/mco.2025.2893
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