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Advances in exosomal non‑coding RNAs in cervical cancer (Review)

  • Authors:
    • Xingkui Xie
    • Hongwei Guan
    • Meng Li
    • Wei Gao
    • Kejia Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Health Management Center, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430070, P.R. China, Department of Ultrasound Imaging, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430060, P.R. China, Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 104
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    Published online on: October 3, 2025
       https://doi.org/10.3892/mco.2025.2899
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Abstract

Exosomes, extracellular vesicles (30‑150 nm in diameter) released upon the fusion of multivesicular bodies with the plasma membrane, are pivotal mediators of intercellular communication through their cargo transport. The present review aimed to provide further insight into the molecular mechanisms by which exosomal non‑coding RNAs (ncRNAs), such as microRNAs, long non‑coding RNAs and circular RNAs, contribute to the development of cervical cancer (CC). There are currently no US Food and Drug Administration‑approved exosome products for medical use. The present review highlights the critical role of exosomal ncRNAs in the pathogenesis of CC, including tumor initiation, progression, metastasis, angiogenesis and drug resistance, and discusses their potential as novel biomarkers for diagnosis, therapeutic targets and prognostic tools for CC. However, the long‑term safety and efficacy of these ncRNAs requires further confirmation by clinical trials, which is essential before exosomes can be broadly adopted in CC. Although exosomes hold significant potential in the diagnosis, therapy and prognosis of CC, several challenges remain to be addressed before their translation into therapeutic use, including the standardization of exosome isolation and storage protocols, the optimization of drug‑loading efficiency, precise control over cargo release kinetics and the completion of extensive clinical trials.
View Figures

Figure 1

Summary of exosomal non-coding RNAs
in cervical cancer. miRNA/miR, microRNA; HOTAIR, HOX transcript
antisense intergenic RNA; MALAT1, metastasis-associated lung
adenocarcinoma transcript 1; EMT, epithelial-mesenchymal
transition; TUG1, taurine upregulated 1; HNF1A-AS1, hepatocyte
nuclear factor 1 homeobox A antisense RNA 1; MEG3, maternally
expressed gene 3.
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Copy and paste a formatted citation
Spandidos Publications style
Xie X, Guan H, Li M, Gao W and Wu K: Advances in exosomal non‑coding RNAs in cervical cancer (Review). Mol Clin Oncol 23: 104, 2025.
APA
Xie, X., Guan, H., Li, M., Gao, W., & Wu, K. (2025). Advances in exosomal non‑coding RNAs in cervical cancer (Review). Molecular and Clinical Oncology, 23, 104. https://doi.org/10.3892/mco.2025.2899
MLA
Xie, X., Guan, H., Li, M., Gao, W., Wu, K."Advances in exosomal non‑coding RNAs in cervical cancer (Review)". Molecular and Clinical Oncology 23.6 (2025): 104.
Chicago
Xie, X., Guan, H., Li, M., Gao, W., Wu, K."Advances in exosomal non‑coding RNAs in cervical cancer (Review)". Molecular and Clinical Oncology 23, no. 6 (2025): 104. https://doi.org/10.3892/mco.2025.2899
Copy and paste a formatted citation
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Spandidos Publications style
Xie X, Guan H, Li M, Gao W and Wu K: Advances in exosomal non‑coding RNAs in cervical cancer (Review). Mol Clin Oncol 23: 104, 2025.
APA
Xie, X., Guan, H., Li, M., Gao, W., & Wu, K. (2025). Advances in exosomal non‑coding RNAs in cervical cancer (Review). Molecular and Clinical Oncology, 23, 104. https://doi.org/10.3892/mco.2025.2899
MLA
Xie, X., Guan, H., Li, M., Gao, W., Wu, K."Advances in exosomal non‑coding RNAs in cervical cancer (Review)". Molecular and Clinical Oncology 23.6 (2025): 104.
Chicago
Xie, X., Guan, H., Li, M., Gao, W., Wu, K."Advances in exosomal non‑coding RNAs in cervical cancer (Review)". Molecular and Clinical Oncology 23, no. 6 (2025): 104. https://doi.org/10.3892/mco.2025.2899
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