Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
December-2025 Volume 23 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2025 Volume 23 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.xlsx
Article Open Access

Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer

  • Authors:
    • Hideyasu Tsumura
    • Dai Koguchi
    • Ken-Ichi Tabata
    • Soichiro Shimura
    • Shuhei Hirano
    • Takefumi Satoh
    • Keiko Takahashi
    • Naomi Araki
    • Rika Kawata
    • Akinori Watanabe
    • Tsutomu Yoshida
    • Jiichiro Sasaki
    • Fumio Takada
    • Kazumasa Matsumoto
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan, Division of Genetics, Department of Genetics, Kitasato University Hospital, Sagamihara, Kanagawa 252‑0375, Japan, Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan, Division of Molecular Pathology, Department of Comprehensive Medicine, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan, Department of Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan
    Copyright: © Tsumura et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 108
    |
    Published online on: October 9, 2025
       https://doi.org/10.3892/mco.2025.2903
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the current status and issues regarding publicly reimbursed comprehensive genomic profiling (CGP) tests in Japan, as well as the implementation status of genetic counseling for cancer susceptibility genes identified by tumor‑only sequencing in patients with prostate cancer. The data of 86 patients with metastatic prostate cancer who underwent CGP tests at a single institution between August 2019 and November 2024 were reviewed using either FoundationOne® CDx (F1CDx; n=63) or FoundationOne® Liquid CDx (F1LCDx; n=23) CGP tests. Of the 86 patients, 19 (22.1%) received genotype‑matched therapy (GMT) under public health insurance (PHI) and 33 (38.4%) received subsequent systemic therapy (SST) because no GMT was identified or available under PHI or in clinical trials. Progression‑free survival was significantly longer in the GMT/PHI group compared with the SST group (median, 6.5 vs. 3.5 months; P=0.006). Declines in serum prostate‑specific antigen levels of ≥50% were more frequent in the GMT/PHI group [9/19 (47.3%)] than in the SST group [7/33 (21.2%)] (P=0.049). Of the 14 suspected carriers of deleterious germline alterations, 7 (50%) received genetic counseling; of which, 6/7 patients underwent confirmatory germline tests and 2 were diagnosed with hereditary breast and ovarian cancer. Cancer genetic medicine offers clinical benefits for patients with metastatic prostate cancer; however, most patients do not receive GMT after CGP testing. The implementation of genetic counseling for cancer susceptibility genes is thus insufficient and requires improvement.
View Figures

Figure 1

Patient profile after genetic testing
in patients with metastatic prostate cancer. BSC, best supportive
care; CIT, company-initiated trial; F1CDx,
FoundationOne® CDx cancer genome profiling; F1LCDx,
FoundationOne® Liquid CDx cancer genome profiling; GMT,
genotype-matched therapy; PHI, public health insurance; PRMCS,
patient-requested medical care system (phase II); IIT,
investigator-initiated trial; SST, subsequent systemic therapy.

Figure 2

PSA response in (A) the GMT/PHI
group, and (B) the SST group. GMT, genotype-matched therapy; PHI,
public health insurance; MSI, microsatellite instability; PSA,
prostate-specific antigen; SST, subsequent systemic therapy.

Figure 3

Progression-free survival in the
GMT/PHI and SST groups. GMT, genotype-matched therapy; PHI, public
health insurance; SST, subsequent systemic therapy.

Figure 4

Comparison of progression-free
survival between the GMT/PHI group and each SST subgroup with (A)
ARSI rechallenge (n=6), (B) ethinylestradiol ± Ra223 (n=7), (C)
cabazitaxel (n=13) and (D) docetaxel (n=4). ARSI, second-generation
androgen receptor signaling inhibitor; GMT, genotype-matched
therapy; PHI, public health insurance; SST, subsequent systemic
therapy.

Figure 5

Overall survival in the GMT/PHI and
non-GMT groups. GMT, genotype-matched therapy; PHI, public health
insurance.
View References

1 

Kikuchi J, Ohhara Y, Takada K, Tanabe H, Hatanaka K, Amano T, Hatanaka KC, Hatanaka Y, Mitamura T, Kato M, et al: Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan. Jpn J Clin Oncol. 51:753–761. 2021.PubMed/NCBI View Article : Google Scholar

2 

de Bono J, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, Chi KN, Sartor O, Agarwal N, Olmos D, et al: Olaparib for metastatic castration-resistant prostate cancer. N Engl J Med. 382:2091–2102. 2020.PubMed/NCBI View Article : Google Scholar

3 

Saad F, Clarke NW, Oya M, Shore N, Procopio G, Guedes JD, Arslan C, Mehra N, Parnis F, Brown E, et al: Olaparib plus abiraterone versus placebo plus abiraterone in metastatic castration-resistant prostate cancer (PROpel): Final prespecified overall survival results of a randomised, double-blind, phase 3 trial. Lancet Oncol. 24:1094–1108. 2023.PubMed/NCBI View Article : Google Scholar

4 

Agarwal N, Azad AA, Carles J, Fay AP, Matsubara N, Heinrich D, Szczylik C, Giorgi UD, Joung JY, Fong PCC, et al: Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): A randomised, placebo-controlled, phase 3 trial. Lancet. 402:291–303. 2023.PubMed/NCBI View Article : Google Scholar

5 

Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, Wong YN, Hahn N, Kohli M, Cooney MM, et al: Chemohormonal therapy in metastatic Hormone-Sensitive prostate cancer. N Engl J Med. 373:737–746. 2015.PubMed/NCBI View Article : Google Scholar

6 

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1). Available from: http://www.jca.gr.jp/researcher/topics/2020/files/20200518.pdf Accessed June 27, 2023.

7 

Koguchi D, Tsumura H, Tabata K, Shimura S, Satoh T, Ikeda M, Watanabe A, Yoshida T, Sasaki J, Matsumoto K and Iwamura M: Real-world data on the comprehensive genetic profiling test for Japanese patients with metastatic Castration-resistant prostate cancer. Jpn J Clin Oncol. 53:569–576. 2024.PubMed/NCBI View Article : Google Scholar

8 

Clinical Practice Guidance for Prostate Cancer. Available from: https://jua.members-web.com/topics1/uploads/attach/topic. Accessed December 1, 2023.

9 

Scher HI, Morris MJ, Stadler WM, Higano C, Basch E, Fizazi K, Antonarakis ES, Beer TM, Carducci MA, Chi KN, et al: Trial design and objectives for Castration-resistant prostate cancer: Updated recommendations from the prostate cancer clinical trials working group 3. J Clin Oncol. 34:1402–1418. 2016.PubMed/NCBI View Article : Google Scholar

10 

Le Tourneau C, Delord JP, Goncalves A, Gavoille C, Dubot C, Isambert N, Campone M, Trédan O, Massiani MA, Mauborgne C, et al: Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): A multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial. Lancet Oncol. 16:1324–1334. 2015.PubMed/NCBI View Article : Google Scholar

11 

Belin L, Kamal M, Mauborgne C, Plancher C, Mulot F, Delord JP, Gonçalves A, Gavoille C, Dubot C, Isambert N, et al: Randomized phase II trial comparing molecularly targeted therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: Cross-over analysis from the SHIVA trial. Ann Oncol. 28:590–596. 2017.PubMed/NCBI View Article : Google Scholar

12 

Krämer A, Bochtler T, Pauli C, Shiu KK, Cook N, Janoski de Menezes J, Pazo-Cid RA, Losa F, Robbrecht DGJ, Tomášek J, et al: Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): An open-label, randomised, phase 2 study. Lancet. 404:527–539. 2024.PubMed/NCBI View Article : Google Scholar

13 

Sandhu S, Moore CM, Chiong E, Beltran H, Bristow RG and Williams SG: Prostate cancer. Lancet. 398:1075–1090. 2021.PubMed/NCBI View Article : Google Scholar

14 

Mateo J, Seed G, Bertan C, Rescigno P, Dolling D, Figueiredo I, Miranda S, Nava Rodrigues D, Gurel B, Clarke M, et al: Genomics of lethal prostate cancer at diagnosis and castration resistance. J Clin Invest. 30:1743–1751. 2020.PubMed/NCBI View Article : Google Scholar

15 

Swisher EM, Kristeleit RS, Oza AM, Tinker AV, Ray-Coquard I, Oaknin A, Coleman RL, Burris HA, Aghajanian C, O'Malley DM, et al: Characterization of patients with long-term responses to rucaparib treatment in recurrent ovarian cancer. Gynecol Oncol. 163:490–497. 2021.PubMed/NCBI View Article : Google Scholar

16 

Buonaiuto R, Neola G, Caltavituro A, Longobardi A, Mangiacotti FP, Cefaliello A, Lamia MR, Pepe F, Ventriglia J, Malapelle U, et al: Efficacy of PARP inhibitors in advanced high-grade serous ovarian cancer according to BRCA domain mutations and mutation type. Front Oncol. 14(1412807)2024.PubMed/NCBI View Article : Google Scholar

17 

Lenis AT, Ravichandran V, Brown S, Alam SM, Katims A, Truong H, Reisz PA, Vasselman S, Nweji B, Autio KA, et al: Microsatellite instability, tumor mutational burden, and response to immune checkpoint blockade in patients with prostate cancer. Clin Cancer Res. 30:3894–3903. 2024.PubMed/NCBI View Article : Google Scholar

18 

Abida W, Armenia J, Gopalan A, Brennan R, Walsh M, Barron D, Danila D, Rathkopf D, Morris M, Slovin S, et al: Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making. JCO Precis Oncol. 2017(PO.17.00029)2017.PubMed/NCBI View Article : Google Scholar

19 

Barata P, Agarwal N, Nussenzveig R, Gerendash B, Jaeger E, Hatton W, Ledet E, Lewis B, Layton J, Babiker H, et al: Clinical activity of pembrolizumab in metastatic prostate cancer with microsatellite instability high (MSI-H) detected by circulating tumor DNA. J Immunother Cancer. 8(e001065)2020.PubMed/NCBI View Article : Google Scholar

20 

Landi L, D'Inca F, Gelibter A, Chiari R, Grossi F, Delmonte A, Passaro A, Signorelli D, Gelsomino F, Galetta D, et al: Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer. J Immunother Cancer. 7(316)2019.PubMed/NCBI View Article : Google Scholar

21 

Yang K, Li J, Bai C, Sun Z and Zhao L: Efficacy of immune checkpoint inhibitors in Non-small-cell lung cancer patients with different metastatic sites: A systematic review and meta-analysis. Front Oncol. 10(1098)2020.PubMed/NCBI View Article : Google Scholar

22 

Zhu YJ, Chang XS, Zhou R, Chen YD, Ma HC, Xiao ZZ, Qu X, Liu YH, Liu LR, Li Y, et al: Bone metastasis attenuates efficacy of immune checkpoint inhibitors and displays ‘cold’ immune characteristics in Non-small cell lung cancer. Lung Cancer. 166:189–196. 2022.PubMed/NCBI View Article : Google Scholar

23 

Hong DS, DuBois SG, Kummar S, Farago AF, Albert CM, Rohrberg KS, van Tilburg CM, Nagasubramanian R, Berlin JD, Federman N, et al: Larotrectinib in patients with TRK fusion-positive solid tumours: A pooled analysis of three phase 1/2 clinical trials. Lancet Oncol. 21:531–540. 2020.PubMed/NCBI View Article : Google Scholar

24 

Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, et al: Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: Integrated analysis of three phase 1-2 trials. Lancet Oncol. 21:271–282. 2020.PubMed/NCBI View Article : Google Scholar

25 

Shimoi T, Sunami K, Tahara M, Nishiwaki S, Tanaka S, Baba E, Kanai M, Kinoshita I, Shirota H, Hayashi H, et al: Dabrafenib and trametinib administration in patients with BRAF V600E/R or non-V600 BRAF mutated advanced solid tumours (BELIEVE, NCCH1901): A multicentre, open-label, and single-arm phase II trial. EClinicalMedicine. 69(102447)2024.PubMed/NCBI View Article : Google Scholar

26 

Subbiah V, Wolf J, Konda B, Kang H, Spira A, Weiss J, Takeda M, Ohe Y, Khan S, Ohashi K, et al: Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): A phase 1/2, open-label, basket trial. Lancet Oncol. 23:1261–1273. 2022.PubMed/NCBI View Article : Google Scholar

27 

Owsley J, Stein MK, Porter J, In GK, Salem M, O'Day S, Elliott A, Poorman K, Gibney G and VanderWalde A: Prevalence of class I-III BRAF mutations among 114,662 cancer patients in a large genomic database. Exp Biol Med (Maywood). 246:31–39. 2021.PubMed/NCBI View Article : Google Scholar

28 

Ueki A, Yoshida R, Kosaka T and Matsubayashi H: Clinical risk management of breast, ovarian, pancreatic, and prostatic cancers for BRCA1/2 variant carriers in Japan. J Hum Genet. 68:517–526. 2023.PubMed/NCBI View Article : Google Scholar

29 

Page EC, Bancroft EK, Brook MN, Assel M, Al Battat MH, Thomas S, Taylor N, Chamberlain A, Pope J, Ni Raghallaigh H, et al: Interim results from the IMPACT study: Evidence for prostate-specific antigen screening in BRCA2 mutation carriers. Eur Urol. 76:831–842. 2019.PubMed/NCBI View Article : Google Scholar

30 

Marchetti C, De Felice F, Palaia I, Perniola G, Musella A, Musio D, Muzii L, Tombolini V and Panici PB: Risk-reducing salpingo-oophorectomy: A meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers. BMC Womens Health. 14(150)2014.PubMed/NCBI View Article : Google Scholar

31 

Usui Y, Taniyama Y, Endo M, Koyanagi YN, Kasugai Y, Oze I, Ito H, Imoto I, Tanaka T, Tajika M, et al: Helicobacter pylori, Homologous-recombination genes, and gastric cancer. N Engl J Med. 388:1181–1190. 2023.PubMed/NCBI View Article : Google Scholar

32 

Lubinski J, Kotsopoulos J, Moller P, Pal T, Eisen A, Peck L, Karlan BY, Aeilts A, Eng C, Bordeleau L, et al: MRI surveillance and breast cancer mortality in women with BRCA1 and BRCA2 sequence variations. JAMA Oncol. 10:493–499. 2024.PubMed/NCBI View Article : Google Scholar

33 

Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, et al: Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med. 375:443–453. 2016.PubMed/NCBI View Article : Google Scholar

34 

Kawamura M, Shirota H, Niihori T, Komine K, Takahashi M, Takahashi S, Miyauchi E, Niizuma H, Kikuchi A, Tada H, et al: Management of patients with presumed germline pathogenic variant from tumor-only genomic sequencing: A retrospective analysis at a single facility. J Hum Genet. 68:399–408. 2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tsumura H, Koguchi D, Tabata K, Shimura S, Hirano S, Satoh T, Takahashi K, Araki N, Kawata R, Watanabe A, Watanabe A, et al: Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer. Mol Clin Oncol 23: 108, 2025.
APA
Tsumura, H., Koguchi, D., Tabata, K., Shimura, S., Hirano, S., Satoh, T. ... Matsumoto, K. (2025). Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer. Molecular and Clinical Oncology, 23, 108. https://doi.org/10.3892/mco.2025.2903
MLA
Tsumura, H., Koguchi, D., Tabata, K., Shimura, S., Hirano, S., Satoh, T., Takahashi, K., Araki, N., Kawata, R., Watanabe, A., Yoshida, T., Sasaki, J., Takada, F., Matsumoto, K."Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer". Molecular and Clinical Oncology 23.6 (2025): 108.
Chicago
Tsumura, H., Koguchi, D., Tabata, K., Shimura, S., Hirano, S., Satoh, T., Takahashi, K., Araki, N., Kawata, R., Watanabe, A., Yoshida, T., Sasaki, J., Takada, F., Matsumoto, K."Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer". Molecular and Clinical Oncology 23, no. 6 (2025): 108. https://doi.org/10.3892/mco.2025.2903
Copy and paste a formatted citation
x
Spandidos Publications style
Tsumura H, Koguchi D, Tabata K, Shimura S, Hirano S, Satoh T, Takahashi K, Araki N, Kawata R, Watanabe A, Watanabe A, et al: Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer. Mol Clin Oncol 23: 108, 2025.
APA
Tsumura, H., Koguchi, D., Tabata, K., Shimura, S., Hirano, S., Satoh, T. ... Matsumoto, K. (2025). Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer. Molecular and Clinical Oncology, 23, 108. https://doi.org/10.3892/mco.2025.2903
MLA
Tsumura, H., Koguchi, D., Tabata, K., Shimura, S., Hirano, S., Satoh, T., Takahashi, K., Araki, N., Kawata, R., Watanabe, A., Yoshida, T., Sasaki, J., Takada, F., Matsumoto, K."Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer". Molecular and Clinical Oncology 23.6 (2025): 108.
Chicago
Tsumura, H., Koguchi, D., Tabata, K., Shimura, S., Hirano, S., Satoh, T., Takahashi, K., Araki, N., Kawata, R., Watanabe, A., Yoshida, T., Sasaki, J., Takada, F., Matsumoto, K."Current status and issues regarding genetic medicine after cancer gene panel testing in Japanese patients with metastatic prostate cancer". Molecular and Clinical Oncology 23, no. 6 (2025): 108. https://doi.org/10.3892/mco.2025.2903
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team