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Article

Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia

  • Authors:
    • Chihiro Suzuki
    • Michio Kimura
    • Makiko Go
    • Yoshiaki Ikeda
    • Eiseki Usami
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmaceutical Sciences, Kinjo Gakuin University, Nagoya, Aichi 463‑8521, Japan, Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu 503‑8502, Japan
  • Article Number: 6
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    Published online on: November 7, 2025
       https://doi.org/10.3892/mco.2025.2915
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Abstract

The present study aimed to evaluate the impact of initial dose reduction of trifluridine/tipiracil (TAS‑102) monotherapy on the incidence of severe neutropenia and overall survival (OS) in individuals with metastatic colorectal cancer, considering prior chemotherapy‑induced severe neutropenia. Participants were classified into the following three groups: A group, individuals who did not experience severe neutropenia during previous chemotherapy and did not undergo dose reduction (n=61); B1 group, those who experienced severe neutropenia during previous chemotherapy and received an initial dose reduction of TAS‑102 (n=28); and B2 group, those who experienced severe neutropenia but did not receive a dose reduction (n=88). Neutropenia severity, progression‑free survival (PFS) and OS were compared among the groups. Notably, there was no significant difference in the incidence of grade 3 or higher neutropenia among the three groups during TAS‑102 administration (P=0.958). The median OS times in the A group (n=61), B1 group (n=28) and B2 group (n=88) were 273 days (95% CI, 199‑299), 285 days (95% CI, 202‑NA) and 233 days (95% CI, 182‑272), respectively (log‑rank test, P=0.165). The median PFS times among the three groups were 133.0 days (95% CI, 98‑153), 94.5 days (95% CI, 77‑133) and 93.5 days (95% CI, 83‑100), respectively (log‑rank test, P=0.053). In conclusion, a proactive dose reduction at TAS‑102 treatment initiation based on pre‑existing severe neutropenia should be carefully considered, as it may not be necessary.
View Figures

Figure 1

Flow diagram. TAS-102,
trifluridine/tipiracil combination tablet; Bmab, bevacizumab.

Figure 2

Kaplan-Meier survival curves for
overall survival based on neutropenia severity. The Kaplan-Meier
survival curves illustrate overall survival following therapy with
TAS-102 in 3 patient groups, including absent, mild (grade 1 or 2
neutropenia), and severe (grade 3 or 4 neutropenia). A significant
difference was observed among the 3 groups (P<0.001). TAS-102,
trifluridine/tipiracil combination tablet.

Figure 3

Kaplan-Meier survival curves for
overall and progression-free survival among three groups. The
Kaplan-Meier survival curves depict (A) overall survival and (B)
progression-free survival following therapy with TAS-102 in the 3
patient groups: (A group) individuals who did not experience severe
neutropenia during previous chemotherapy and did not undergo dose
reduction (n=61); (B1 group) those who experienced severe
neutropenia during previous chemotherapy and received an initial
dose reduction of TAS-102 (n=28); (B2 group) those who had severe
neutropenia but did not receive a dose reduction (n=88). No
significant difference in survival was observed among the groups.
TAS-102, trifluridine/tipiracil combination tablet.

Figure 4

Kaplan-Meier survival curves for
overall and progression-free survival between the high and low Ccr
groups. The Kaplan-Meier survival curves illustrate (A) overall
survival and (B) progression-free survival following TAS-102
therapy in the high and low Ccr groups. No significant difference
in survival was observed between the groups. Ccr, creatinine
clearance; TAS-102, trifluridine/tipiracil combination tablet.
View References

1 

Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Tabernero J, Komatsu Y, et al: Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 372:1909–1919. 2015.PubMed/NCBI View Article : Google Scholar

2 

Xu J, Kim TW, Shen L, Sriuranpong V, Pan H, Xu R, Guo W, Han SW, Liu T, Park YS, et al: Results of a randomized, double-blind, placebo-controlled, phase III trial of trifluridine/tipiracil (TAS-102) monotherapy in Asian patients with previously treated metastatic colorectal cancer: The TERRA study. J Clin Oncol. 36:350–358. 2018.PubMed/NCBI View Article : Google Scholar

3 

Pfeiffer P, Yilmaz M, Möller S, Zitnjak D, Krogh M, Petersen LN, Poulsen LØ, Winther SB, Thomsen KG and Qvortrup C: TAS-102 with or without bevacizumab in patients with chemorefractory metastatic colorectal cancer: An investigator-initiated, open-label, randomised, phase 2 trial. Lancet Oncol. 21:412–420. 2020.PubMed/NCBI View Article : Google Scholar

4 

Kimura M, Usami E, Iwai M, Teramachi H and Yoshimura T: Severe neutropenia: A prognosticator in patients with advanced/recurrent colorectal cancer under oral trifluridine-tipiracil (TAS-102) chemotherapy. Pharmazie. 72:49–52. 2017.PubMed/NCBI View Article : Google Scholar

5 

Nose Y, Kagawa Y, Hata T, Mori R, Kawai K, Naito A, Sakamoto T, Murakami K, Katsura Y, Ohmura Y, et al: Neutropenia is an indicator of outcomes in metastatic colorectal cancer patients treated with FTD/TPI plus bevacizumab: A retrospective study. Cancer Chemother Pharmacol. 86:427–433. 2020.PubMed/NCBI View Article : Google Scholar

6 

Kasi PM, Kotani D, Cecchini M, Shitara K, Ohtsu A, Ramanathan RK, Hochster HS, Grothey A and Yoshino T: Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: A cohort study. BMC Cancer. 16(467)2016.PubMed/NCBI View Article : Google Scholar

7 

Kamiimabeppu D, Osumi H, Shinozaki E, Ooki A, Wakatsuki T, Yoshino K, Sato T, Nakayama I, Ogura M, Takahari D, et al: Effect of neutropenia on survival outcomes of patients with metastatic colorectal cancer receiving trifluridine/tipiracil plus bevacizumab. Oncol Lett. 22(783)2021.PubMed/NCBI View Article : Google Scholar

8 

US Department Of Health And Human Services: Common terminology criteria for adverse events (CTCAE) version 5.0. United States, National Cancer Institute, 2017. (https://ctep.Cancer.Gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5×11.pdf).

9 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013.PubMed/NCBI View Article : Google Scholar

10 

Ikagawa M, Kimura M, Iwai M, Usami E, Yoshimura T and Yasuda K: Neutropenia as a prognostic factor and safety of second-line therapy with S-1 for advanced or recurrent pancreatic cancer. Mol Clin Oncol. 5:283–288. 2016.PubMed/NCBI View Article : Google Scholar

11 

Kimura K, Usami E and Yoshimura T: Association between severe neutropenia and progression-free survival in patients with advanced or recurrent breast cancer treated with Palbociclib. Pharmazie. 75:662–665. 2020.PubMed/NCBI View Article : Google Scholar

12 

Watanabe D, Fujii H, Ohata K, Iihara H, Makiyama A, Kobayashi R, Hirose C, Hishida S, Matsuoka S, Tajima JY, et al: Prognostic impact of severe neutropenia in colorectal cancer patients treated with TAS-102 and bevacizumab, addressing immortal-time bias. BMC Cancer. 23(1078)2023.PubMed/NCBI View Article : Google Scholar

13 

Domínguez Senín L, Rodriguez Garcés MY, Aviñó Tarazona V, Amor Urbano M, Santos-Rubio MD and Bayo Calero J: Analysis of neutropenia as a predictive factor of the efficacy of trifluridine-tipiracil treatment. Int J Clin Pharmacol Ther. 61:346–353. 2023.PubMed/NCBI View Article : Google Scholar

14 

Giuliani J and Bonetti A: The onset of grade ≥3 neutropenia is associated with longer overall survival in metastatic colorectal cancer patients treated with trifluridine/tipiracil. Anticancer Res. 39:3967–3969. 2019.PubMed/NCBI View Article : Google Scholar

15 

Shitara K, Matsuo K, Takahari D, Yokota T, Inaba Y, Yamaura H, Sato Y, Najima M, Ura T and Muro K: Neutropaenia as a prognostic factor in metastatic colorectal cancer patients undergoing chemotherapy with first-line FOLFOX. Eur J Cancer. 45:1757–1763. 2009.PubMed/NCBI View Article : Google Scholar

16 

Shitara K, Matsuo K, Takahari D, Yokota T, Shibata T, Ura T, Ito S, Sawaki A, Tajika M, Kawai H and Muro K: Neutropenia as a prognostic factor in advanced gastric cancer patients undergoing second-line chemotherapy with weekly paclitaxel. Ann Oncol. 21:2403–2409. 2010.PubMed/NCBI View Article : Google Scholar

17 

Gurney H: Dose calculation of anticancer drugs: A review of the current practice and introduction of an alternative. J Clin Oncol. 14:2590–2611. 1996.PubMed/NCBI View Article : Google Scholar

18 

Gamelin E, Delva R, Jacob J, Merrouche Y, Raoul JL, Pezet D, Dorval E, Piot G, Morel A and Boisdron-Celle M: Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: Results of a multicenter randomized trial of patients with metastatic colorectal cancer. J Clin Oncol. 26:2099–2105. 2008.PubMed/NCBI View Article : Google Scholar

19 

Yoshino T, Cleary JM, Van Cutsem E, Mayer RJ, Ohtsu A, Shinozaki E, Falcone A, Yamazaki K, Nishina T, Garcia-Carbonero R, et al: Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials. Ann Oncol. 31:88–95. 2020.PubMed/NCBI View Article : Google Scholar

20 

Yoshino T and Lenz HJ: Reply to the letter to the editor ‘Neutropenia in metastatic colorectal cancer receiving trifluridine/tipiracil’ by Colloca et al. Ann Oncol. 31:1085–1087. 2020.

21 

Grothey A, Yoshino T, Bodoky G, Ciuleanu T, Garcia-Carbonero R, García-Alfonso P, Van Cutsem E, Muro K, Mytelka DS, Li L, et al: Association of baseline absolute neutrophil counts and survival in patients with metastatic colorectal cancer treated with second-line antiangiogenic therapies: Exploratory analyses of the RAISE trial and validation in an electronic medical record data set. ESMO Open. 3(e000347)2018.PubMed/NCBI View Article : Google Scholar

22 

Carus A, Gurney H, Gebski V, Harnett P, Hui R, Kefford R, Wilcken N, Ladekarl M, von der Maase H and Donskov F: Impact of baseline and nadir neutrophil index in non-small cell lung cancer and ovarian cancer patients: Assessment of chemotherapy for resolution of unfavourable neutrophilia. J Transl Med. 11(189)2013.PubMed/NCBI View Article : Google Scholar

23 

Yasue F, Kimura M, Usami E, Iwai M, Kawachi S, Mitsuoka M, Ikeda Y and Yoshimura T: Risk factors contributing to the development of neutropenia in patients receiving oral trifluridine-tipiracil (TAS-102) chemotherapy for advanced/recurrent colorectal cancer. Pharmazie. 73:178–181. 2018.PubMed/NCBI View Article : Google Scholar

24 

Saito Y, Takekuma Y, Komatsu Y and Sugawara M: Impact of renal impairment on early development of severe neutropenia with trifluridine/tipiracil treatment for metastatic colorectal cancer. Sci Rep. 14(26990)2024.PubMed/NCBI View Article : Google Scholar

25 

Gurney H: How to calculate the dose of chemotherapy. Br J Cancer. 86:1297–1302. 2002.PubMed/NCBI View Article : Google Scholar

26 

Newell DR: Getting the right dose in cancer chemotherapy-time to stop using surface area? Br J Cancer. 86:1207–1208. 2002.PubMed/NCBI View Article : Google Scholar

27 

Drami I, Pring ET, Gould L, Malietzis G, Naghibi M, Athanasiou T, Glynne-Jones R and Jenkins JT: Body composition and dose-limiting toxicity in colorectal cancer chemotherapy treatment; a systematic review of the literature. Could muscle mass be the new body surface area in chemotherapy dosing? Clin Oncol (R Coll Radiol). 33:e540–e552. 2021.PubMed/NCBI View Article : Google Scholar

28 

Benson AB, Venook AP, Adam M, Chang G, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming D, Garrido-Laguna I, et al: Colon Cancer, version 3.2024, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 22 (2 D)(e240029)2024.PubMed/NCBI View Article : Google Scholar

29 

Kiss I: New ESMO guidelines for clinical practice in metastatic colorectal cancer-commentary on changes in systemic therapy. Klin Onkol. 36:473–476. 2023.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Suzuki C, Kimura M, Go M, Ikeda Y and Usami E: Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia. Mol Clin Oncol 24: 6, 2026.
APA
Suzuki, C., Kimura, M., Go, M., Ikeda, Y., & Usami, E. (2026). Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia. Molecular and Clinical Oncology, 24, 6. https://doi.org/10.3892/mco.2025.2915
MLA
Suzuki, C., Kimura, M., Go, M., Ikeda, Y., Usami, E."Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia". Molecular and Clinical Oncology 24.1 (2026): 6.
Chicago
Suzuki, C., Kimura, M., Go, M., Ikeda, Y., Usami, E."Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia". Molecular and Clinical Oncology 24, no. 1 (2026): 6. https://doi.org/10.3892/mco.2025.2915
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki C, Kimura M, Go M, Ikeda Y and Usami E: Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia. Mol Clin Oncol 24: 6, 2026.
APA
Suzuki, C., Kimura, M., Go, M., Ikeda, Y., & Usami, E. (2026). Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia. Molecular and Clinical Oncology, 24, 6. https://doi.org/10.3892/mco.2025.2915
MLA
Suzuki, C., Kimura, M., Go, M., Ikeda, Y., Usami, E."Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia". Molecular and Clinical Oncology 24.1 (2026): 6.
Chicago
Suzuki, C., Kimura, M., Go, M., Ikeda, Y., Usami, E."Impact of TAS‑102 dose reduction on severe neutropenia and survival outcomes in patients with metastatic colorectal cancer and prior chemotherapy‑induced neutropenia". Molecular and Clinical Oncology 24, no. 1 (2026): 6. https://doi.org/10.3892/mco.2025.2915
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