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Coexistence of gynecological pathology with endometriosis and adenomyosis

  • Authors:
    • Michail Matalliotakis
    • Ioannis Tsakiridis
    • Charoula Matalliotaki
    • Konstantinos Krithinakis
    • Demetrios A. Spandidos
    • Themistoklis Dagklis
    • Apostolos Mamopoulos
    • Ioannis Kalogiannidis
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Venizeleio General Hospital, 71409 Heraklion, Greece, Third Department of Obstetrics and Gynecology, Ippokrateio General Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Third Department of Obstetrics and Gynecology, Ippokrateio General Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    Copyright: © Matalliotakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 12
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    Published online on: December 12, 2025
       https://doi.org/10.3892/mco.2025.2921
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Abstract

Both endometriosis and adenomyosis can impact quality of life. Endometriosis is a chronic, benign, condition characterized by the growth of endometrium outside the uterus, which affects ~10% of women from menarche to menopause, globally. Adenomyosis is a benign gynecological condition, which is defined as the infiltration of ectopic endometrial tissue within the underlying myometrium. It is often diagnosed in perimenopausal women aged 40‑50 years, with a prevalence that varies widely (ranging from 1‑70%). The aim of the present study was to determine the histological coexistence of gynecological pathology in women with endometriosis, adenomyosis and those with both. In the present retrospective study, data retrieved from the medical records of women that underwent abdominal hysterectomy with bilateral or unilateral salpingo‑oophorectomy at the Department of Obstetrics and Gynecology of Venizeleio General Hospital and the Third Department of Obstetrics and Gynecology of Aristotle University of Thessaloniki (Greece) between 2000‑2022 were included. Patients were divided into three groups; group 1 included those with endometriosis, group 2 included those with adenomyosis and group 3 included those with both endometriosis and adenomyosis. Cases with inadequate medical records and those lacking histological diagnoses were excluded. The total number of patients included in the present study was 1,692 women; group 1 included 495 (29.2%) patients, group 2 included 1,096 (64.8%) patients and group 3 included 101 (6.0%) patients. The results of the present study revealed that the most common pathology was leiomyomas (43.3%), followed by endometrial and cervical polyps (17.6 and 9.8%, respectively). Benign ovarian (12.2%) and paraovarian cysts (13.7%) were also observed. Compared with groups 1 and 2, leiomyomas were significantly more common in group 3 (67.3%). Endometrial cancer was significantly more common in group 2 (9.3%), compared with group 1 (1.6%) and group 3 (4%). The present study suggested that endometriosis, adenomyosis or the concomitant presence of both may coexist with various benign and malignant gynecological diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Matalliotakis M, Tsakiridis I, Matalliotaki C, Krithinakis K, Spandidos DA, Dagklis T, Mamopoulos A and Kalogiannidis I: Coexistence of gynecological pathology with endometriosis and adenomyosis. Mol Clin Oncol 24: 12, 2026.
APA
Matalliotakis, M., Tsakiridis, I., Matalliotaki, C., Krithinakis, K., Spandidos, D.A., Dagklis, T. ... Kalogiannidis, I. (2026). Coexistence of gynecological pathology with endometriosis and adenomyosis. Molecular and Clinical Oncology, 24, 12. https://doi.org/10.3892/mco.2025.2921
MLA
Matalliotakis, M., Tsakiridis, I., Matalliotaki, C., Krithinakis, K., Spandidos, D. A., Dagklis, T., Mamopoulos, A., Kalogiannidis, I."Coexistence of gynecological pathology with endometriosis and adenomyosis". Molecular and Clinical Oncology 24.2 (2026): 12.
Chicago
Matalliotakis, M., Tsakiridis, I., Matalliotaki, C., Krithinakis, K., Spandidos, D. A., Dagklis, T., Mamopoulos, A., Kalogiannidis, I."Coexistence of gynecological pathology with endometriosis and adenomyosis". Molecular and Clinical Oncology 24, no. 2 (2026): 12. https://doi.org/10.3892/mco.2025.2921
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Spandidos Publications style
Matalliotakis M, Tsakiridis I, Matalliotaki C, Krithinakis K, Spandidos DA, Dagklis T, Mamopoulos A and Kalogiannidis I: Coexistence of gynecological pathology with endometriosis and adenomyosis. Mol Clin Oncol 24: 12, 2026.
APA
Matalliotakis, M., Tsakiridis, I., Matalliotaki, C., Krithinakis, K., Spandidos, D.A., Dagklis, T. ... Kalogiannidis, I. (2026). Coexistence of gynecological pathology with endometriosis and adenomyosis. Molecular and Clinical Oncology, 24, 12. https://doi.org/10.3892/mco.2025.2921
MLA
Matalliotakis, M., Tsakiridis, I., Matalliotaki, C., Krithinakis, K., Spandidos, D. A., Dagklis, T., Mamopoulos, A., Kalogiannidis, I."Coexistence of gynecological pathology with endometriosis and adenomyosis". Molecular and Clinical Oncology 24.2 (2026): 12.
Chicago
Matalliotakis, M., Tsakiridis, I., Matalliotaki, C., Krithinakis, K., Spandidos, D. A., Dagklis, T., Mamopoulos, A., Kalogiannidis, I."Coexistence of gynecological pathology with endometriosis and adenomyosis". Molecular and Clinical Oncology 24, no. 2 (2026): 12. https://doi.org/10.3892/mco.2025.2921
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