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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2026 Volume 24 Issue 4

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Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer

  • Authors:
    • Diao Wei
    • Tianyu Lei
    • Yuhang Che
    • Qinyong Hu

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Renmin Hospital of Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 24
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    Published online on: February 13, 2026
       https://doi.org/10.3892/mco.2026.2933
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Abstract

UTP4 is a critical component of ribosome biogenesis, and its dysregulation may contribute to cancer development. However, the role of UTP4 in cancer remains unclear. The present study comprehensively investigated the expression and prognostic significance of UTP4 across multiple cancers, with a particular focus on gastric cancer (GC). Integrated bioinformatics analysis of public datasets, including The Cancer Genome Atlas, revealed that UTP4 is frequently overexpressed in various tumors and associated with poor prognosis. Further analysis uncovered its correlations with genetic mutations, immune infiltration and immune checkpoint expression. Based on these findings and CRISPR‑Cas9 screening predictions, the functional role of UTP4 in GC cells was experimentally validated. The results demonstrated that UTP4 knockdown significantly inhibited cell proliferation, migration and invasion. These findings highlight UTP4 as a novel pan‑cancer biomarker and potential therapeutic target, providing a foundation for further clinical investigations.

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Copy and paste a formatted citation
Spandidos Publications style
Wei D, Lei T, Che Y and Hu Q: <p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>. Mol Clin Oncol 24: 24, 2026.
APA
Wei, D., Lei, T., Che, Y., & Hu, Q. (2026). <p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>. Molecular and Clinical Oncology, 24, 24. https://doi.org/10.3892/mco.2026.2933
MLA
Wei, D., Lei, T., Che, Y., Hu, Q."<p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>". Molecular and Clinical Oncology 24.4 (2026): 24.
Chicago
Wei, D., Lei, T., Che, Y., Hu, Q."<p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>". Molecular and Clinical Oncology 24, no. 4 (2026): 24. https://doi.org/10.3892/mco.2026.2933
Copy and paste a formatted citation
x
Spandidos Publications style
Wei D, Lei T, Che Y and Hu Q: <p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>. Mol Clin Oncol 24: 24, 2026.
APA
Wei, D., Lei, T., Che, Y., & Hu, Q. (2026). <p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>. Molecular and Clinical Oncology, 24, 24. https://doi.org/10.3892/mco.2026.2933
MLA
Wei, D., Lei, T., Che, Y., Hu, Q."<p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>". Molecular and Clinical Oncology 24.4 (2026): 24.
Chicago
Wei, D., Lei, T., Che, Y., Hu, Q."<p>Pan‑cancer analysis and experimental validation reveal UTP4 as a novel biomarker for gastric cancer</p>". Molecular and Clinical Oncology 24, no. 4 (2026): 24. https://doi.org/10.3892/mco.2026.2933
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