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Article Open Access

Colorectal cancer demographics in Barbados

  • Authors:
    • Sahle Griffith
    • Greg Padmore
    • Emil Phillips
    • Solange S.K. Ramkissoon
    • Sierra  Moore
    • Keisha Walkes
    • Abdelaziz A. Gohar
    • Shamir O. Cawich
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Queen Elizabeth Hospital, Bridgetown, Barbados, Department of Clinical Surgical Sciences, University of The West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago, South Valley University, Qena 83523, Egypt
    Copyright: © Griffith et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
    |
    Published online on: April 28, 2021
       https://doi.org/10.3892/mi.2021.2
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Abstract

Barbados is an island in the Eastern Caribbean that is reported to have the 8th highest incidence of colorectal cancer (CRC) worldwide. However, these figures are based only on estimates, and there is little available epidemiological data collected from Barbadians with CRC. The present study sought to collect epidemiologic data from patients in Barbados diagnosed with CRC. This information is considered important to shape national public health policies. For this purpose, hospital admission registers at all tertiary care facilities in Barbados were retrospectively audited over a four‑year period from January 1, 2014 to December 31, 2018 to identify patients who underwent operative treatment for CRC. The following data were extracted: Age, sex, ethnicity, the location of the primary tumour and tumour stage. Descriptive statistical analyses were generated using SPSS version 21.0. The results revealed that there were 97 patients with CRC at a mean age of 64.9 years (SD ±12.2) and a male preponderance (1.3:1). The majority (93.8%) were from the African diaspora. Only 18.5% of diagnoses were made at (opportunistic) screening. Consequently, two thirds of the patients had advanced‑stage disease at diagnosis. The disease staging of the patients was as follows: Stage 0 (1%), stage I (10.3%), stage II (23.7%), stage III (38.1%) and stage IV (26.8%). Right‑sided primary tumours were most common (44.3%), followed by left‑sided (41.2%) and rectal lesions (14.4%). Women were significantly more likely to have right‑sided lesions (55 vs. 45%) and males were more likely to have rectal lesions (77 vs. 23%). On the whole, the present study highlights the need to implement a national screening programme in this high‑risk population of African origin with a predominantly right‑sided distribution of CRC primary tumours. This is reinforced by the fact that 10% of patients will be diagnosed before the age of 50 years with more aggressive disease.
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1 

Government of Barbados: Demographics of the Nation. https://www.gov.bb/Visit-Barbados/demographics. Accessed January 15, 2021.

2 

World Health Organization (WHO): Globocan Statistics 2020. WHO, Geneva, 2020. https://gco.iarc.fr/today/data/factsheets/populations/52-barbados-fact-sheets.pdf. Accessed January 30, 2021.

3 

Mukund K, Syulyukina N, Ramamoorthy S and Subramaniam S: Right and left-sided colon cancers-specificity of molecular mechanisms in tumorigenesis and progression. BMC Cancer. 20(317)2020.PubMed/NCBI View Article : Google Scholar

4 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

5 

Rose AMC, Campbell JM, Forde SA, Hambleton I, Greaves N and Prussia P: Cancer in Barbados 2013: Annual report of the BNR-Cancer. The George Alleyne Chronic Disease Research Centre, the University of the West Indies, St Michael, Barbados. http://www.bnr.org.bb/cms/index.php?option=com_remository&Itemid=61&func=startdown&id=45. Accessed March 1, 2021.

6 

World Cancer Research Fund (WCRF), American Institute for Cancer Research: Colorectal cancer statistics. WCRF International, London, 2019. https://www.wcrf.org/dietandcancer/cancer-trends/colorectal-cancer-statistics. Accessed January 4, 2021.

7 

Zbar AP, Inniss M, Prussia PR and Shenoy R: The changing distribution of colorectal cancer in Barbados: 1985-2004. Dis Colon Rectum. 50:1215–1222. 2001.PubMed/NCBI View Article : Google Scholar

8 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 383:1490–1502. 2014.PubMed/NCBI View Article : Google Scholar

9 

Yang Y, Wang G, He J, Ren S, Wu F, Zhang J and Wang F: Gender differences in colorectal cancer survival: A meta-analysis. Int J Cancer. 141:1942–1949. 2017.PubMed/NCBI View Article : Google Scholar

10 

Paulson EC, Wirtalla C, Armstrong K and Mahmoud NJ: Gender influences treatment and survival in colorectal cancer surgery. Dis Colon Rectum. 52:1982–1991. 2009.PubMed/NCBI View Article : Google Scholar

11 

Berger MD, Yang D, Sunakawa Y, Zhang W, Ning Y, Matsusaka S, Okazaki S, Miyamoto Y, Suenaga M, Schirripa M, et al: Impact of sex, age, and ethnicity/race on the survival of patients with rectal cancer in the United States from 1988 to 2012. Oncotarget. 7:53668–53678. 2016.PubMed/NCBI View Article : Google Scholar

12 

Press OA, Zhang W, Gordon MA, Yang D, Lurje G, Iqbal S, El-Khoueiry A and Lenz HJ: Gender-related survival differences associated with EGFR polymorphisms in metastatic colon cancer. Cancer Res. 68:3037–3042. 2008.PubMed/NCBI View Article : Google Scholar

13 

McFarlane MEC, Rhoden A, Fletcher PR and Carpenter R: Cancer of the colon and rectum in a Jamaican population: Diagnostic implications of the changing frequency and subsite distribution. West Ind Med J. 53:170–173. 2004.PubMed/NCBI

14 

Plummer JM, Leake PA, Ferron-Boothe D, Roberts PO, Mitchell DI and McFarlane MEC: Colorectal cancer survival in Jamaica. Ann Med Surg (Lond). 6:26–29. 2016.PubMed/NCBI View Article : Google Scholar

15 

Rampersad MK, Mohammed SR and Jurawan R: A Single centre retrospective review of colorectal cancer in Trinidad over a 3-year period. Gastroent Hepatol Open Access. 8:264–268. 2017.

16 

Joachim C, Veronique-Baudin J, Razanakaivo M, Macni J, Pomier A, Dorival MJ, Smith-Ravin J, Piere-Lois O and Escarmant P: Trends in colorectal cancer in the Caribbean: A population-based study in Martinique, 1982-2011. Rev Epidemiol Sante Publique. 65:181–188. 2017.PubMed/NCBI View Article : Google Scholar

17 

Gabriel E, Attwood K, Al-Sukhni E, Erwin D, Boland P and Nurkin S: Age-related rates of colorectal cancer and the factors associated with overall survival. J Gastrointest Oncol. 9:96–110. 2018.PubMed/NCBI View Article : Google Scholar

18 

Augustus GJ and Ellis NA: Colorectal cancer disparity in African Americans: Risk factors and carcinogenic mechanisms. Am J Pathol. 188:291–303. 2018.PubMed/NCBI View Article : Google Scholar

19 

American Cancer Society: Cancer Facts & Figure 2019. American Cancer Society, Atlanta, 2019. https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2019/cancer-facts-and-figures-2019.pdf.

20 

Simon MS, Thomson CA, Pettijohn E, Kato I, Rodabough RJ, Lane D, Hubbel FA, O'Sullivan MJ, Adams-Campbell L, Mouton CP, et al: Racial differences in colorectal cancer incidence and mortality in the Women's Health Initiative. Cancer Epidemiol Biomarkers Prev. 20:1368–1378. 2019.PubMed/NCBI View Article : Google Scholar

21 

Staudacher JJ, Yazici C, Bul V, Zeidan J, Khalid A, Xia Y, Krett N and Jung B: Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in sporadic colorectal cancer. Clin Transl Gastroenterol. 8(e124)2017.PubMed/NCBI View Article : Google Scholar

22 

Ollberding NJ, Nomura AMY, Wilkens LR, Henderson BE and Kolonel LN: Racial/ethnic differences in colorectal cancer risk: The multiethnic cohort study. Int J cancer. 129:1899–1906. 2011.PubMed/NCBI View Article : Google Scholar

23 

Askari A, Nachiappan S, Currie A, Latchford A, Stebbing J, Bottle A, Athanasiou T and Faiz O: The relationship between ethnicity, social deprivation and late presentation of colorectal cancer. Cancer Epidemiol. 47:88–93. 2017.PubMed/NCBI View Article : Google Scholar

24 

Baran B, Mert Ozupek N, Yerli Tetik N, Acar E, Bekcioglu O and Baskin Y: Difference between left-sided and right-sided colorectal cancer: A focused review of literature. Gastroenterol Res. 11:264–273. 2018.PubMed/NCBI View Article : Google Scholar

25 

Hansen IO and Jess PM: Possible better long-term survival in left versus right-sided colon cancer-a systematic review. Dan Med J. 59(A4444)2012.PubMed/NCBI

26 

Kim SE, Paik HY, Yoon H, Lee JE, Kim N and Sung MK: Sex and gender-specific disparities in colorectal cancer risk. World J Gastroenterol. 21:5167–5175. 2015.PubMed/NCBI View Article : Google Scholar

27 

Elsaleh H, Joseph D, Grieu F, Zeps N, Spry N and Lacopetta B: Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet. 355:1745–1750. 2000.PubMed/NCBI View Article : Google Scholar

28 

Pan American Health Organization (PAHO): Colorectal Cancer Screening in the Americas. Situation and Challenges. PAHO, Washington, DC, 2016. https://www.paho.org/hq/dmdocuments/2016/Colorectal-Cancer-Screening-Landscape-English.pdf.

29 

Guindalini RS, Win AK, Gulden C, Lindor NM, Newcomb PA, Haile RW, Raymond V, Stoffel E, Hall M, Llor X, et al: Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome. Gastroenterol. 149:1446–1453. 2015.PubMed/NCBI View Article : Google Scholar

30 

Weber TK, Chin HM, Rodriguez-Bigas M, Keitz B, Gilligan R, O'Malley L, Urf E, Diba N, Pazik J and Petrelli NJ: Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer. JAMA. 281:2316–2320. 1991.PubMed/NCBI View Article : Google Scholar

31 

Inra JA, Steyerberg EW, Grover S, McFarland A, Syngal S and Kastrinos F: Racial variation in frequency and phenotypes of APC and MUTYH mutations in 6,169 individuals undergoing genetic testing. Genet Med. 17:815–821. 2017.PubMed/NCBI View Article : Google Scholar

32 

Ashktorab H, Smoot DT, Carethers JM, Rahmanian M, Kittles R, Vosganian G, Doura M, Nidhiry E, Naab T, Momen B, et al: High incidence of microsatellite instability in colorectal cancer from African Americans. Clin Cancer Res. 9:1112–1117. 2003.PubMed/NCBI

33 

Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, Hylind L, Iacosozio-Dononue C, Carethers JM, Goel A, Boland CR and Giardiello FM: Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer. 116:914–919. 2005.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Griffith S, Padmore G, Phillips E, Ramkissoon SS, Moore S, Walkes K, Gohar AA and Cawich SO: Colorectal cancer demographics in Barbados. Med Int 1: 2, 2021.
APA
Griffith, S., Padmore, G., Phillips, E., Ramkissoon, S.S., Moore, S., Walkes, K. ... Cawich, S.O. (2021). Colorectal cancer demographics in Barbados. Medicine International, 1, 2. https://doi.org/10.3892/mi.2021.2
MLA
Griffith, S., Padmore, G., Phillips, E., Ramkissoon, S. S., Moore, S., Walkes, K., Gohar, A. A., Cawich, S. O."Colorectal cancer demographics in Barbados". Medicine International 1.1 (2021): 2.
Chicago
Griffith, S., Padmore, G., Phillips, E., Ramkissoon, S. S., Moore, S., Walkes, K., Gohar, A. A., Cawich, S. O."Colorectal cancer demographics in Barbados". Medicine International 1, no. 1 (2021): 2. https://doi.org/10.3892/mi.2021.2
Copy and paste a formatted citation
x
Spandidos Publications style
Griffith S, Padmore G, Phillips E, Ramkissoon SS, Moore S, Walkes K, Gohar AA and Cawich SO: Colorectal cancer demographics in Barbados. Med Int 1: 2, 2021.
APA
Griffith, S., Padmore, G., Phillips, E., Ramkissoon, S.S., Moore, S., Walkes, K. ... Cawich, S.O. (2021). Colorectal cancer demographics in Barbados. Medicine International, 1, 2. https://doi.org/10.3892/mi.2021.2
MLA
Griffith, S., Padmore, G., Phillips, E., Ramkissoon, S. S., Moore, S., Walkes, K., Gohar, A. A., Cawich, S. O."Colorectal cancer demographics in Barbados". Medicine International 1.1 (2021): 2.
Chicago
Griffith, S., Padmore, G., Phillips, E., Ramkissoon, S. S., Moore, S., Walkes, K., Gohar, A. A., Cawich, S. O."Colorectal cancer demographics in Barbados". Medicine International 1, no. 1 (2021): 2. https://doi.org/10.3892/mi.2021.2
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