Relapse of Graves' disease following SARS‑CoV‑2 infection: A case report and brief literature review
- Saeed Rashaad Mohammed
- Mallika Tripathi
- Narine Mack
- Surujpal Teelucksingh
Affiliations: Department of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago, San Fernando General Hospital, South West Regional Health Authority, San Fernando, Trinidad and Tobago
- Published online on: December 21, 2021 https://doi.org/10.3892/mi.2021.25
Copyright: © Mohammed
et al. This is an open access article distributed under the
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Commons Attribution License.
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The interaction between severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and autoimmune thyroid disease is an emerging phenomenon. The present study describes the case of a 28‑year‑old female who experienced a relapse of Graves' disease following SARS‑CoV‑2 infection. She was biochemically euthyroid for 2 years prior to COVID‑19 infection. However, she began experiencing palpitations, increased sweating and tremors of the hands 9 days after being diagnosed with COVID‑19‑related pneumonia. In addition to presenting this case, a comparison is made of this case to similar reports and the possible mechanisms underlying the association between SARS‑CoV‑2 and Graves' disease are discussed. One is a direct result of viral uptake by thyroid cells, while another is a result of the hyperinflammatory ʻcytokine storm’ and its effects on the hypothalamic‑pituitary‑thyroid axis and T‑cell immunity.