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Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease

  • Authors:
    • Masaaki Kubota
    • Bo-Shi Zhang
    • Shu-Yang Li
    • Yoichi Yoshida
    • Hao Wang
    • Akihiko Adachi
    • Tomoo Matsutani
    • Seiichiro Mine
    • Toshio Machida
    • Ikuo Kamitsukasa
    • Takeshi Wada
    • Akiyo Aotsuka
    • Kenichiro Kitamura
    • Hirotaka Takizawa
    • Hideyuki Kuroda
    • Yasuo Iwadate
    • Takaki Hiwasa
  • View Affiliations / Copyright

    Affiliations: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan, Department of Neurology, Chiba Rosai Hospital, Chiba 290‑0003, Japan, Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba 260‑0852, Japan, Kitakurihama Takuchi Clinic, Yokosuka, Kanagawa 239‑0807, Japan, Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba 260‑0025, Japan, Medical Project Division, Research Development Center, Fujikura Kasei Co., Saitama 340‑0203, Japan
    Copyright: © Kubota et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 4
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    Published online on: December 21, 2022
       https://doi.org/10.3892/mi.2022.64
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Abstract

Autoantibodies can be used in the early diagnosis and treatment of atherosclerosis‑related diseases. Using ProtoArray® screening of samples from patients with atherosclerosis, the present study identified thiosulfate sulfurtransferase‑like domain‑containing 2 (TSTD2) as a novel atherosclerosis antigen. The serum TSTD2 antibody levels were then quantified using an amplified luminescent proximity homogeneous assay‑linked immunosorbent assay. This demonstrated the levels of TSTD2 antibodies (TSTD2‑Abs) to be significantly higher in patients with acute cerebral infarction or chronic kidney disease than in healthy donors. The TSTD2‑Ab levels were also found to be higher in males, older adults, smokers, in those who consumed alcohol regularly, and in those with hypertension. Furthermore, Spearman's rank correlation analysis revealed TSTD2‑Ab levels to be strongly associated with measures of atherosclerosis severity, including plaque scores, intima‑media thickness of the carotid artery and the cardio‑ankle vascular index. Thus, TSTD2‑Abs may thus be a promising novel biomarker for atherosclerosis‑related cerebral infarction and kidney disease.
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Copy and paste a formatted citation
Spandidos Publications style
Kubota M, Zhang B, Li S, Yoshida Y, Wang H, Adachi A, Matsutani T, Mine S, Machida T, Kamitsukasa I, Kamitsukasa I, et al: Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease. Med Int 3: 4, 2023.
APA
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A. ... Hiwasa, T. (2023). Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease. Medicine International, 3, 4. https://doi.org/10.3892/mi.2022.64
MLA
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A., Matsutani, T., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kitamura, K., Takizawa, H., Kuroda, H., Iwadate, Y., Hiwasa, T."Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease". Medicine International 3.1 (2023): 4.
Chicago
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A., Matsutani, T., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kitamura, K., Takizawa, H., Kuroda, H., Iwadate, Y., Hiwasa, T."Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease". Medicine International 3, no. 1 (2023): 4. https://doi.org/10.3892/mi.2022.64
Copy and paste a formatted citation
x
Spandidos Publications style
Kubota M, Zhang B, Li S, Yoshida Y, Wang H, Adachi A, Matsutani T, Mine S, Machida T, Kamitsukasa I, Kamitsukasa I, et al: Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease. Med Int 3: 4, 2023.
APA
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A. ... Hiwasa, T. (2023). Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease. Medicine International, 3, 4. https://doi.org/10.3892/mi.2022.64
MLA
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A., Matsutani, T., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kitamura, K., Takizawa, H., Kuroda, H., Iwadate, Y., Hiwasa, T."Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease". Medicine International 3.1 (2023): 4.
Chicago
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A., Matsutani, T., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kitamura, K., Takizawa, H., Kuroda, H., Iwadate, Y., Hiwasa, T."Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease". Medicine International 3, no. 1 (2023): 4. https://doi.org/10.3892/mi.2022.64
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