Short‑term effects of pregabalin plus exercise therapy on pain, emotional status, physical function and nociceptive responses in patients with fibromyalgia
- Onur Velioglu
- Mustafa Turgut Yildizgoren
- Halil Ogut
- Hayal Guler
- Ayse Dicle Turhanoglu
Affiliations: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Mustafa Kemal University, Alahan, Hatay 31001, Turkey
- Published online on: August 9, 2023 https://doi.org/10.3892/mi.2023.101
Copyright : © Velioglu
et al. This is an open access article distributed under the
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Commons Attribution License [CC BY 4.0].
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The aim of the present study was to investigate the effects of pregabalin plus exercise vs. pregabalin treatment alone on the electromyographic nociceptive flexion reflex (NFR) threshold in patients with fibromyalgia (FM). For this purpose, the present study included a total of 40 patients diagnosed with FM according to the American College of Rheumatology 2010 criteria. The patients were divided into two groups as follows: Group 1 received pregabalin treatment only and group 2 received exercise therapy in addition to pregabalin treatment. Assessments were made at baseline and at the 1st month using a visual analog scale (VAS) to measure pain, the Fibromyalgia Impact Questionnaire (FIQ) to measure the severity of FM, Beck's Depression Inventory (BDI) to measure depression and the NFR to measure the compressive forces on peripheral nerves. In both groups, the NFR threshold following treatment was significantly higher than that at the baseline results (P<0.001). There was no significant difference between the groups as regards the difference from pre‑ to post‑treatment NFR threshold values (P=0.610 and P=0.555, respectively). There was a strong, negative correlation between the pre‑treatment NFR threshold and VAS resting, VAS motion and FIQ scores (Rho=‑0.62, Rho=‑0.69 and Rho=‑0.60, respectively). There was a moderate negative correlation between the pre‑treatment NFR threshold and BDI scores (Rho=‑0.35). On the whole, the present study demonstrates that in the treatment of FM, pregabalin improves the clinical scores and leads to an increase in the NFR threshold. Herewith, it should be noted that short‑term exercise therapy does not appear to provide additional benefits.