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A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis

  • Authors:
    • Kamil Mursit Yildiz
    • Hayal Guler
    • Halil Ogut
    • Mustafa Turgut Yildizgoren
    • Ayse Dicle Turhanoglu
  • View Affiliations / Copyright

    Affiliations: Department of Physical Medicine and Rehabilitation, Medical School, Hatay Mustafa Kemal University, Antakya, Hatay, 31001, Turkey, Department of Physical Medicine and Rehabilitation, Konya City Hospital, Karatay, Konya 42020, Turkey, Department of Physical Medicine and Rehabilitation, Medical School, Hatay Mustafa Kemal University, Antakya, Hatay, 31001, Turkey
    Copyright: © Yildiz et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 45
    |
    Published online on: August 29, 2023
       https://doi.org/10.3892/mi.2023.105
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Abstract

The aim of the present study was to compare the efficacy of hypertonic dextrose prolotherapy (HDP) with conventional physiotherapy (CPT) in improving symptoms in females with knee osteoarthritis (OA). The present study included 60 patients with a diagnosis of knee OA. The patients were randomly assigned to the HDP (n=30) and CPT (n=30) groups. The patients in the HDP group were treated with a dextrose injection into the knee joint (25% dextrose) and around the knee (15% dextrose) in two sessions for 1 month, while those in the CPT group received a hot pack, transcutaneous electrical nerve stimulation and therapeutic ultrasound in five sessions a week for 4 weeks. Prior to commencing the treatment, and at 1 and 3 months post‑treatment, all the patients were evaluated using the visual analog scale (VAS), Western Ontario and McMaster Osteoarthritis Index (WOMAC), the goniometric measurement of active knee range of motion (ROM), a 50‑m walking test and isokinetic knee muscle strength measurements. There were no statistically significant differences between the two groups as regards the demographic characteristics at pre‑treatment (P>0.05). However, at 1 and 3 months post‑treatment, the scores of all the outcome parameters were significantly improved in the HDP group compared with the CPT group (P<0.05 for all). In both groups, a significant improvement was observed in the VAS scores, WOMAC total values and ROM following the treatments, with the greatest improvement observed in the HDP group (P<0.001). The isokinetic quadriceps peak torque measurements were increased in both groups following treatment. All the scores exhibited a statistically significant improvement in the HDP group at both 1 and 3 months post‑treatment. On the whole, the results of the present study demonstrate that both HDP and CPT are effective treatment modalities to relieve pain, and increase functionality and strength in patients with knee OA. However, greater improvements in pain and functionality can be achieved with prolotherapy.
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1 

Uysal A, Yildizgoren MT, Guler H and Turhanoglu AD: Effects of radial extracorporeal shock wave therapy on clinical variables and isokinetic performance in patients with knee osteoarthritis: A prospective, randomized, single-blind, and controlled trial. Int Orthop. 44:1311–1319. 2020.PubMed/NCBI View Article : Google Scholar

2 

Wee TC, Neo EJR and Tan YL: Dextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis. J Clin Orthop Trauma. 19:108–117. 2021.PubMed/NCBI View Article : Google Scholar

3 

Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, et al: 2019 American College of rheumatology/arthritis foundation guideline for the management of osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 72:149–162. 2020.PubMed/NCBI View Article : Google Scholar

4 

Öğüt H, Güler H, Yıldızgören MT, Velioğlu O and Turhanoğlu AD: Does kinesiology taping improve muscle strength and function in knee osteoarthritis? A single-blind, Randomized and controlled study. Arch Rheumatol. 33:335–343. 2018.PubMed/NCBI View Article : Google Scholar

5 

Basedow M, Runciman WB, March L and Esterman A: Australians with osteoarthritis; the use of and beliefs about complementary and alternative medicines. Complement Ther Clin Pract. 20:237–242. 2014.PubMed/NCBI View Article : Google Scholar

6 

Reeves KD, Sit RW and Rabago DP: Dextrose prolotherapy: A narrative review of basic science, clinical research, and best treatment recommendations. Phys Med Rehabil Clin N Am. 27:783–823. 2016.PubMed/NCBI View Article : Google Scholar

7 

Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA and Zgierska A: Dextrose prolotherapy for knee osteoarthritis: A randomized controlled trial. Ann Fam Med. 11:229–237. 2013.PubMed/NCBI View Article : Google Scholar

8 

Reeves KD and Hassanein K: Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med. 6:68–74, 77-80. 2000.PubMed/NCBI

9 

Rezasoltani Z, Taheri M, Mofrad MK and Mohajerani SA: Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res. 10:1179–1187. 2017.PubMed/NCBI View Article : Google Scholar

10 

Kohn MD, Sassoon AA and Fernando ND: Classifications in Brief: Kellgren-Lawrence classification of osteoarthritis. Clin Orthop Relat Res. 474:1886–1893. 2016.PubMed/NCBI View Article : Google Scholar

11 

Roos EM, Klässbo M and Lohmander LS: WOMAC osteoarthritis index. Reliability, validity, and responsiveness in patients with arthroscopically assessed osteoarthritis. Western Ontario and MacMaster Universities. Scand J Rheumatol. 28:210–215. 1999.PubMed/NCBI View Article : Google Scholar

12 

Nguyen C, Lefèvre-Colau MM, Poiraudeau S and Rannou F: Rehabilitation (exercise and strength training) and osteoarthritis: A critical narrative review. Ann Phys Rehabil Med. 59:190–195. 2016.PubMed/NCBI View Article : Google Scholar

13 

Brosseau L, Yonge KA, Robinson V, Marchand S, Judd M, Wells G and Tugwell P: Thermotherapy for treatment of osteoarthritis. Cochrane Database Syst Rev. 2003(CD004522)2003.PubMed/NCBI View Article : Google Scholar

14 

Goh SL, Persson MSM, Stocks J, Hou Y, Lin J, Hall MC, Doherty M and Zhang W: Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis. Ann Phys Rehabil Med. 62:356–365. 2019.PubMed/NCBI View Article : Google Scholar

15 

Soliman DMI, Sherif NM, Omar OH and El Zohiery AK: Healing effects of prolotherapy in treatment of knee osteoarthritis healing effects of prolotherapy in treatment of knee osteoarthritis. Egyptian Rheumatol Rehab. 43:47–52. 2016.

16 

Dumais R, Benoit C, Dumais A, Babin L, Bordage R, de Arcos C, Allard J and Bélanger M: Effect of regenerative injection therapy on function and pain in patients with knee osteoarthritis: A randomized crossover study. Pain Med. 13:990–999. 2012.PubMed/NCBI View Article : Google Scholar

17 

Rahimzadeh P, Imani F, Faiz SHR, Entezary SR, Zamanabadi MN and Alebouyeh MR: The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clin Interv Aging. 13:73–79. 2018.PubMed/NCBI View Article : Google Scholar

18 

Hassan F, Trebinjac S, Murrell WD and Maffulli N: The effectiveness of prolotherapy in treating knee osteoarthritis in adults: A systematic review. Br Med Bull. 122:91–108. 2017.PubMed/NCBI View Article : Google Scholar

19 

Rabago D, Zgierska A, Fortney L, Kijowski R, Mundt M, Ryan M, Grettie J and Patterson JJ: Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: Results of a single-arm uncontrolled study with 1-year follow-up. J Altern Complement Med. 18:408–414. 2012.PubMed/NCBI View Article : Google Scholar

20 

Wang J, Liang J, Yao J, Song HX, Yang XT, Wu FC, Ye Y, Li JH and Wu T: Meta-analysis of clinical trials focusing on hypertonic dextrose prolotherapy (HDP) for knee osteoarthritis. Aging Clin Exp Res. 34:715–724. 2022.PubMed/NCBI View Article : Google Scholar

21 

Arias-Vázquez PI, Tovilla-Zárate CA, Legorreta-Ramírez BG, Burad Fonz W, Magaña-Ricardez D, González-Castro TB, Juárez-Rojop IE and López-Narváez ML: Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: Systematic review of clinical trials. Adv Rheumatol. 59(39)2019.PubMed/NCBI View Article : Google Scholar

22 

Hsu C, Vu K and Borg-Stein J: Prolotherapy: A narrative review of mechanisms, techniques, and protocols, and evidence for common musculoskeletal conditions. Phys Med Rehabil Clin N Am. 34:165–180. 2023.PubMed/NCBI View Article : Google Scholar

23 

Han DS, Lee CH, Shieh YD, Chang CT, Li MH, Chu YC, Wang JL, Chang KV, Lin SH and Chen CC: A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain. Pain. 163:e622–e633. 2022.PubMed/NCBI View Article : Google Scholar

24 

van Tittelboom V, Alemdaroglu-Gürbüz I, Hanssen B, Heyrman L, Feys H, Desloovere K, Calders P and Van den Broeck C: Reliability of isokinetic strength assessments of knee and hip using the biodex system 4 dynamometer and associations with functional strength in healthy children. Front Sports Act Living. 4(817216)2022.PubMed/NCBI View Article : Google Scholar

25 

Şahin N, Baskent A, Ugurlu H and Berker E: Isokinetic evaluation of both knee extensor/flexor muscle strength in patients with hypermobility syndrome. Rheumatol Int. 28:643–648. 2008.PubMed/NCBI View Article : Google Scholar

26 

Myers BJ: Isokinetic Testing of Muscle Strength in Older Adults with Knee Osteoarthritis: An Integrative Review. Isokin Exer Sci. 8:269–290. 2020.

27 

Baert IAC, Meeus M, Mahmoudian A, Luyten FP, Nijs J and Verschueren SMP: Do psychosocial factors predict muscle strength, pain, or physical performance in patients with knee osteoarthritis? J Clin Rheumatol. 23:308–316. 2017.PubMed/NCBI View Article : Google Scholar

28 

Gür H, Cakin N, Akova B, Okay E and Küçükoğlu S: Concentric versus combined concentric-eccentric isokinetic training: Effects on functional capacity and symptoms in patients with osteoarthrosis of the knee. Arch Phys Med Rehabil. 83:308–316. 2002.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Yildiz KM, Guler H, Ogut H, Yildizgoren MT and Turhanoglu AD: A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis. Med Int 3: 45, 2023.
APA
Yildiz, K.M., Guler, H., Ogut, H., Yildizgoren, M.T., & Turhanoglu, A.D. (2023). A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis. Medicine International, 3, 45. https://doi.org/10.3892/mi.2023.105
MLA
Yildiz, K. M., Guler, H., Ogut, H., Yildizgoren, M. T., Turhanoglu, A. D."A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis". Medicine International 3.5 (2023): 45.
Chicago
Yildiz, K. M., Guler, H., Ogut, H., Yildizgoren, M. T., Turhanoglu, A. D."A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis". Medicine International 3, no. 5 (2023): 45. https://doi.org/10.3892/mi.2023.105
Copy and paste a formatted citation
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Spandidos Publications style
Yildiz KM, Guler H, Ogut H, Yildizgoren MT and Turhanoglu AD: A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis. Med Int 3: 45, 2023.
APA
Yildiz, K.M., Guler, H., Ogut, H., Yildizgoren, M.T., & Turhanoglu, A.D. (2023). A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis. Medicine International, 3, 45. https://doi.org/10.3892/mi.2023.105
MLA
Yildiz, K. M., Guler, H., Ogut, H., Yildizgoren, M. T., Turhanoglu, A. D."A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis". Medicine International 3.5 (2023): 45.
Chicago
Yildiz, K. M., Guler, H., Ogut, H., Yildizgoren, M. T., Turhanoglu, A. D."A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis". Medicine International 3, no. 5 (2023): 45. https://doi.org/10.3892/mi.2023.105
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