Open Access

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)

  • Authors:
    • Stelios Kokkoris
    • Angeliki Kanavou
    • Panagiotis Kremmydas
    • Dimitrios Katsaros
    • Stavros Karageorgiou
    • Aikaterini Gkoufa
    • Vasiliki Epameinondas Georgakopoulou
    • Demetrios A. Spandidos
    • Charalampos Giannopoulos
    • Marina Kardamitsi
    • Christina Routsi
  • View Affiliations

  • Published online on: September 14, 2023     https://doi.org/10.3892/mi.2023.112
  • Article Number: 52
  • Copyright : © Kokkoris et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

In the context of coronavirus disease 2019 (COVID‑19), laboratory medicine has played a crucial role in both diagnosis and severity assessment. Although the importance of baseline laboratory findings has been extensively reported, data regarding their evolution over the clinical course are limited. The aim of the present narrative review was to provide the dynamic changes of the routine laboratory variables reported in patients with severe COVID‑19 over the course of their critical illness. A search was made of the literature for articles providing data on the time‑course of routine laboratory tests in patients with severe COVID‑19 during their stay in the intensive care unit (ICU). White blood cell, neutrophil and lymphocyte counts, neutrophil to lymphocyte ratio, platelet counts, as well as D‑dimer, fibrinogen, C‑reactive protein, lactate dehydrogenase and serum albumin levels were selected as disease characteristics and routine laboratory parameters. A total of 25 research articles reporting dynamic trends in the aforementioned laboratory parameters over the clinical course of severe COVID‑19 were identified. During the follow‑up period provided by each study, the majority of the laboratory values remained persistently abnormal in both survivors and non‑survivors. Furthermore, in the majority of studies, the temporal trends of laboratory values distinctly differentiated patients between survivors and non‑survivors. In conclusion, there are distinct temporal trends in selected routine laboratory parameters between survivors and non‑survivors with severe COVID‑19 admitted to the ICU, indicating their importance in the prognosis of clinical outcome.
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September-October 2023
Volume 3 Issue 5

Print ISSN: 2754-3242
Online ISSN:2754-1304

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Spandidos Publications style
Kokkoris S, Kanavou A, Kremmydas P, Katsaros D, Karageorgiou S, Gkoufa A, Georgakopoulou VE, Spandidos DA, Giannopoulos C, Kardamitsi M, Kardamitsi M, et al: Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review). Med Int 3: 52, 2023.
APA
Kokkoris, S., Kanavou, A., Kremmydas, P., Katsaros, D., Karageorgiou, S., Gkoufa, A. ... Routsi, C. (2023). Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review). Medicine International, 3, 52. https://doi.org/10.3892/mi.2023.112
MLA
Kokkoris, S., Kanavou, A., Kremmydas, P., Katsaros, D., Karageorgiou, S., Gkoufa, A., Georgakopoulou, V. E., Spandidos, D. A., Giannopoulos, C., Kardamitsi, M., Routsi, C."Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)". Medicine International 3.5 (2023): 52.
Chicago
Kokkoris, S., Kanavou, A., Kremmydas, P., Katsaros, D., Karageorgiou, S., Gkoufa, A., Georgakopoulou, V. E., Spandidos, D. A., Giannopoulos, C., Kardamitsi, M., Routsi, C."Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)". Medicine International 3, no. 5 (2023): 52. https://doi.org/10.3892/mi.2023.112