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Article Open Access

Castleman disease: Experience from a single institution

  • Authors:
    • Sherry S. Abraham
    • Geetha Narayanan
    • Sugeeth Mangalapilly Thambi
    • Jayasudha Arundhathi Vasudevan
    • Deepa Susan Joy Philip
    • Prakash N. Purushothaman
    • Sreejith G. Nair
    • Rekha Nair
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala 695011, India, Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala 695011, India
    Copyright: © Abraham et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 56
    |
    Published online on: October 6, 2023
       https://doi.org/10.3892/mi.2023.116
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Abstract

Castleman disease (CD) describes a group of rare heterogeneous lymphoproliferative disorders characterized by enlarged hyperplastic lymph nodes. It is classified into unicentric CD (UCD) and multicentric CD (MCD). The present retrospective study examined the data of 11 patients with CD diagnosed and treated at a tertiary cancer center from 2017 to 2022. The median age of the study group was 41 years (range, 24 to 68 years). There were 8 males and 3 females. In total, 7 patients were diagnosed with UCD and 4 patients with MCD. The hyaline‑vascular variant was the most common histology in both UCD and MCD. Among the 7 patients with UCD, 5 patients underwent excision, 1 patient underwent debulking followed by radiotherapy and 1 patient received single agent rituximab. Of the patients with UCD, 6 had a complete response (CR) and 1 patient had a partial response (PR). All 4 patients with MCD received systemic treatment, which included single agent rituximab (2 patients), rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (RCHOP) (1 patient) and CHOP (1 patient). Among the patients with MCD, 1 patient attained a CR, 2 patients had a PR and 1 patient succumbed. The 3‑year survival rate for the study population was 91%. In summary, CD is a rare disease occurring in immunodeficient patients. UCD is more common and is associated with better outcomes. Surgery is the mainstay of management in UCD whereas MCD requires combination chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Abraham SS, Narayanan G, Thambi SM, Vasudevan JA, Joy Philip DS, Purushothaman PN, Nair SG and Nair R: Castleman disease: Experience from a single institution. Med Int 3: 56, 2023.
APA
Abraham, S.S., Narayanan, G., Thambi, S.M., Vasudevan, J.A., Joy Philip, D.S., Purushothaman, P.N. ... Nair, R. (2023). Castleman disease: Experience from a single institution. Medicine International, 3, 56. https://doi.org/10.3892/mi.2023.116
MLA
Abraham, S. S., Narayanan, G., Thambi, S. M., Vasudevan, J. A., Joy Philip, D. S., Purushothaman, P. N., Nair, S. G., Nair, R."Castleman disease: Experience from a single institution". Medicine International 3.6 (2023): 56.
Chicago
Abraham, S. S., Narayanan, G., Thambi, S. M., Vasudevan, J. A., Joy Philip, D. S., Purushothaman, P. N., Nair, S. G., Nair, R."Castleman disease: Experience from a single institution". Medicine International 3, no. 6 (2023): 56. https://doi.org/10.3892/mi.2023.116
Copy and paste a formatted citation
x
Spandidos Publications style
Abraham SS, Narayanan G, Thambi SM, Vasudevan JA, Joy Philip DS, Purushothaman PN, Nair SG and Nair R: Castleman disease: Experience from a single institution. Med Int 3: 56, 2023.
APA
Abraham, S.S., Narayanan, G., Thambi, S.M., Vasudevan, J.A., Joy Philip, D.S., Purushothaman, P.N. ... Nair, R. (2023). Castleman disease: Experience from a single institution. Medicine International, 3, 56. https://doi.org/10.3892/mi.2023.116
MLA
Abraham, S. S., Narayanan, G., Thambi, S. M., Vasudevan, J. A., Joy Philip, D. S., Purushothaman, P. N., Nair, S. G., Nair, R."Castleman disease: Experience from a single institution". Medicine International 3.6 (2023): 56.
Chicago
Abraham, S. S., Narayanan, G., Thambi, S. M., Vasudevan, J. A., Joy Philip, D. S., Purushothaman, P. N., Nair, S. G., Nair, R."Castleman disease: Experience from a single institution". Medicine International 3, no. 6 (2023): 56. https://doi.org/10.3892/mi.2023.116
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