Pleomorphic giant cell carcinoma of the prostate: A case report and mini‑review of the literature

Fakhralddin,Saman Salih; Ali,Rawa M.; Abdullah,Ari M.; Faraj,Farman Mohammed; Hussein,Dlsoz M.; Mohammed,Shvan H.; Abdalla,Berun A.; Kakamad,Fahmi H.; Rahim,Hawbash M.

doi:10.3892/mi.2023.120

November-December 2023 Volume 3 Issue 6

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November-December 2023 Volume 3 Issue 6

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Case Report Open Access

Pleomorphic giant cell carcinoma of the prostate: A case report and mini‑review of the literature

Authors:
- Saman Salih Fakhralddin
- Rawa M. Ali
- Ari M. Abdullah
- Farman Mohammed Faraj
- Dlsoz M. Hussein
- Shvan H. Mohammed
- Berun A. Abdalla
- Fahmi H. Kakamad
- Hawbash M. Rahim
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Affiliations: College of Medicine, University of Sulaimani, Sulaimani, Kurdistan 46001, Iraq, Department of Scientific Affairs, Smart Health Tower, University of Human Development, Sulaimani, Kurdistan 46001, Iraq, Sulaimaniyah Surgical Teaching Hospital, University of Human Development, Sulaimani, Kurdistan 46001, Iraq, Kscien Organization, University of Human Development, Sulaimani, Kurdistan 46001, Iraq

Copyright: © Fakhralddin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 60
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Published online on: November 10, 2023

https://doi.org/10.3892/mi.2023.120
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Abstract

Pleomorphic giant cell carcinoma (PGCC) is an exceptionally uncommon form of prostate adenocarcinoma. It consists of unusually large and irregular cells with varied nuclei. The present study describes a rare case of prostatic PGCC. A 65‑year‑old male patient presented to the urology clinic with severe dysuria, nocturia, and frequent, urgent, and difficult urination for a period of 3 months. Pelvic magnetic resonance imaging revealed a large pelvic mass. A prostate biopsy was performed, and immunohistochemical analysis revealed positivity for the pan‑epithelial markers, AE1/AE3, alpha‑methyl acyl‑CoA racemase, and focally for sphingolipid activator protein‑2. While waiting for his pathology report, the patient's condition deteriorated, and he was diagnosed with intestinal obstruction. The patient underwent laparotomy and end colostomy. Later, he developed severe sepsis and wound dehiscence. After 2 weeks, the patient succumbed due to multiorgan failure. Prostatic PGCC cases are frequently associated with previous chemo‑, hormone, or radiation therapy. Prior to the diagnosis of PGCC, it is critical to rule out urothelial carcinoma. Early recognition of this rare condition can lead to more effective therapy. Prostatic PGCC is extremely rare. Immunohistochemistry for prostatic markers, such as prostate‑specific membrane antigen, prostate‑specific antigen, NK3 homeobox 1 and androgen receptor, can be used to confirm its origin.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pleomorphic giant cell carcinoma of the prostate: A case report and mini‑review of the literature

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Abstract

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