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Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage

  • Authors:
    • Konstantinos Faropoulos
    • Vasiliki Tsolaki
    • Vasiliki Epameinondas Georgakopoulou
    • Ilias Trakas
    • Kyriakos Tarantinos
    • Petros Papalexis
    • Demetrios A. Spandidos
    • Aikaterini Aravantinou‑Fatorou
    • Nikolaos Mathioudakis
    • Nikolaos Trakas
    • Eleftherios Lavdas
    • George Fotakopoulos
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Nicosia General Hospital, 2029 Nicosia, Cyprus, Department of Pulmonary and Critical Care Medicine, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Infectious Diseases‑COVID19 Unit, Laiko General Hospital, 11527 Athens, Greece, First Department of Pulmonology, Sismanogleio Hospital, 15126 Athens, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Department of Medical Radiological Technologists, Technological Education Institute of Athens, 12243 Athens, Greece, Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece
    Copyright: © Faropoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 19
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    Published online on: March 20, 2023
       https://doi.org/10.3892/mi.2023.79
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Abstract

Cerebral vasospasm (CV) or delayed cerebral ischemia (DCI) constitutes the main reason for the unfavorable outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH). The present retrospective cohort study, through an evaluation with computed tomography (CT) perfusion (CTP), aimed to examine the utility of an intravenous or oral administration of sildenafil in preventing DCI that develops due to vasospasm in these patients. A retrospective cohort study was conducted, which included 34 patients in a tertiary care hospital. Of these patients, 18 were males (52.9%), and the median age was 54.4 years. Of these patients, 18 (52.9%) had undergone surgery, and 16 (47.1%) had an endovascular procedure. CTP was performed on the 3rd to the 6th day. The clinical outcome was documented at 30 days using a CT scan and a complete neurological evaluation, including the Glasgow Coma Scale assessment. There was a statistically significant difference in the number of patients who developed an ischemic event at 1 month between those who did not receive sildenafil compared to those who received sildenafil (P<0.05). In addition, the multivariate analysis revealed that cerebral blood flow was an independent factor for detecting an ischemic event in 1 month (P=0.001). On the whole, the findings of the present study indicate that the intravenous or oral administration of sildenafil may be beneficial for the prevention of DCI.
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Copy and paste a formatted citation
Spandidos Publications style
Faropoulos K, Tsolaki V, Georgakopoulou VE, Trakas I, Tarantinos K, Papalexis P, Spandidos DA, Aravantinou‑Fatorou A, Mathioudakis N, Trakas N, Trakas N, et al: Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage. Med Int 3: 19, 2023.
APA
Faropoulos, K., Tsolaki, V., Georgakopoulou, V.E., Trakas, I., Tarantinos, K., Papalexis, P. ... Fotakopoulos, G. (2023). Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage. Medicine International, 3, 19. https://doi.org/10.3892/mi.2023.79
MLA
Faropoulos, K., Tsolaki, V., Georgakopoulou, V. E., Trakas, I., Tarantinos, K., Papalexis, P., Spandidos, D. A., Aravantinou‑Fatorou, A., Mathioudakis, N., Trakas, N., Lavdas, E., Fotakopoulos, G."Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage". Medicine International 3.2 (2023): 19.
Chicago
Faropoulos, K., Tsolaki, V., Georgakopoulou, V. E., Trakas, I., Tarantinos, K., Papalexis, P., Spandidos, D. A., Aravantinou‑Fatorou, A., Mathioudakis, N., Trakas, N., Lavdas, E., Fotakopoulos, G."Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage". Medicine International 3, no. 2 (2023): 19. https://doi.org/10.3892/mi.2023.79
Copy and paste a formatted citation
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Spandidos Publications style
Faropoulos K, Tsolaki V, Georgakopoulou VE, Trakas I, Tarantinos K, Papalexis P, Spandidos DA, Aravantinou‑Fatorou A, Mathioudakis N, Trakas N, Trakas N, et al: Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage. Med Int 3: 19, 2023.
APA
Faropoulos, K., Tsolaki, V., Georgakopoulou, V.E., Trakas, I., Tarantinos, K., Papalexis, P. ... Fotakopoulos, G. (2023). Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage. Medicine International, 3, 19. https://doi.org/10.3892/mi.2023.79
MLA
Faropoulos, K., Tsolaki, V., Georgakopoulou, V. E., Trakas, I., Tarantinos, K., Papalexis, P., Spandidos, D. A., Aravantinou‑Fatorou, A., Mathioudakis, N., Trakas, N., Lavdas, E., Fotakopoulos, G."Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage". Medicine International 3.2 (2023): 19.
Chicago
Faropoulos, K., Tsolaki, V., Georgakopoulou, V. E., Trakas, I., Tarantinos, K., Papalexis, P., Spandidos, D. A., Aravantinou‑Fatorou, A., Mathioudakis, N., Trakas, N., Lavdas, E., Fotakopoulos, G."Value of sildenafil treatment for the prevention of vasospasm‑related delayed ischemic neurological deficits and delayed brain infarction following aneurysmal subarachnoid hemorrhage". Medicine International 3, no. 2 (2023): 19. https://doi.org/10.3892/mi.2023.79
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