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Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia

  • Authors:
    • Vasiliki Epameinondas Georgakopoulou
    • Aikaterini Gkoufa
    • Anastasia Bougea
    • Dimitrios Basoulis
    • Aristeidis Tsakanikas
    • Sotiria Makrodimitri
    • Georgios Karamanakos
    • Demetrios A. Spandidos
    • Efthalia Angelopoulou
    • Nikolaos V. Sipsas
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases and COVID‑19 Unit, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, 1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, 1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
    Copyright: © Georgakopoulou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 34
    |
    Published online on: July 4, 2023
       https://doi.org/10.3892/mi.2023.94
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Abstract

Patients with Parkinson's disease (PD) and coronavirus disease 2019 (COVID‑19)‑associated pneumonia present, according to the literature, high mortality rates due to the nature of the disease, advanced age, and underlying diseases. Most available studies, however, refer to the first waves of the pandemic. The aim of the present study was to investigate the clinical characteristics and outcomes of elderly patients (≥65 years old) with PD hospitalized with COVID‑19‑associated pneumonia during the period of prevalence of various severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) variants, as well as to determine possible prognostic factors for poor outcomes. During the period from February 15, 2021, to July 15, 2022, 1,144 elderly patients with COVID‑19 pneumonia were hospitalized. Age, sex, Charlson comorbidity index, vaccination status against SARS‑CoV‑2, and admission laboratory parameters were recorded for all patients. A total of 36 (3.1%) patients with PD were hospitalized due to COVID‑19‑associated pneumonia (18 males, 50%). The mean age of the patients was 82.72±8.18 years. In total, 8 patients (22.2%) were hospitalized during the period of alpha variant predominance, 3 patients (8.3%) during the period of delta variant predominance, and 25 patients (69.4%) during the omicron variant predominance period. Of note, 16 patients (44.4%) were vaccinated with at least two doses. In addition, 17 (47.2%) patients succumbed to the disease. Between the patients who survived and those who succumbed, a statistically significant difference was only found in the mean value of albumin (37.48±6.02 vs. 31.97±5.34 g/l, P=0.019). In particular, as shown by receiver operating characteristic curve analysis, albumin exhibited a satisfactory predictive ability for mortality (area under the curve, 0.780; P=0.013) with an albumin value ≤37.7 g/l being able to predict mortality with 85.7% sensitivity and 54.8% specificity. Overall, the findings of the present study indicate that mortality among elderly patients with PD hospitalized with COVID‑19‑associated pneumonia was high in all phases of the pandemic. A low albumin value, not only as an indicator of the immune status, but also of the nutritional status, is a predictor of adverse outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Georgakopoulou VE, Gkoufa A, Bougea A, Basoulis D, Tsakanikas A, Makrodimitri S, Karamanakos G, Spandidos DA, Angelopoulou E, Sipsas NV, Sipsas NV, et al: Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia. Med Int 3: 34, 2023.
APA
Georgakopoulou, V.E., Gkoufa, A., Bougea, A., Basoulis, D., Tsakanikas, A., Makrodimitri, S. ... Sipsas, N.V. (2023). Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia. Medicine International, 3, 34. https://doi.org/10.3892/mi.2023.94
MLA
Georgakopoulou, V. E., Gkoufa, A., Bougea, A., Basoulis, D., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Spandidos, D. A., Angelopoulou, E., Sipsas, N. V."Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia". Medicine International 3.4 (2023): 34.
Chicago
Georgakopoulou, V. E., Gkoufa, A., Bougea, A., Basoulis, D., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Spandidos, D. A., Angelopoulou, E., Sipsas, N. V."Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia". Medicine International 3, no. 4 (2023): 34. https://doi.org/10.3892/mi.2023.94
Copy and paste a formatted citation
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Spandidos Publications style
Georgakopoulou VE, Gkoufa A, Bougea A, Basoulis D, Tsakanikas A, Makrodimitri S, Karamanakos G, Spandidos DA, Angelopoulou E, Sipsas NV, Sipsas NV, et al: Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia. Med Int 3: 34, 2023.
APA
Georgakopoulou, V.E., Gkoufa, A., Bougea, A., Basoulis, D., Tsakanikas, A., Makrodimitri, S. ... Sipsas, N.V. (2023). Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia. Medicine International, 3, 34. https://doi.org/10.3892/mi.2023.94
MLA
Georgakopoulou, V. E., Gkoufa, A., Bougea, A., Basoulis, D., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Spandidos, D. A., Angelopoulou, E., Sipsas, N. V."Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia". Medicine International 3.4 (2023): 34.
Chicago
Georgakopoulou, V. E., Gkoufa, A., Bougea, A., Basoulis, D., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Spandidos, D. A., Angelopoulou, E., Sipsas, N. V."Characteristics and outcomes of elderly patients with Parkinson's disease hospitalized due to COVID‑19‑associated pneumonia". Medicine International 3, no. 4 (2023): 34. https://doi.org/10.3892/mi.2023.94
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