Alveolar adenoma with a single cyst: A case report

Matsui,Hiroshi; Utsumi,Takahiro; Maru,Natsumi; Taniguchi,Yohei; Saito,Tomohito; Hino,Haruaki; Ishida,Kaori; Tsuta,Koji; Murakawa,Tomohiro

doi:10.3892/mi.2024.140

March-April 2024 Volume 4 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March-April 2024 Volume 4 Issue 2

Full Size Image

Case Report Open Access

Alveolar adenoma with a single cyst: A case report

Authors:
- Hiroshi Matsui
- Takahiro Utsumi
- Natsumi Maru
- Yohei Taniguchi
- Tomohito Saito
- Haruaki Hino
- Kaori Ishida
- Koji Tsuta
- Tomohiro Murakawa
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Kansai Medical University Hospital, Hirakata, Osaka 573‑1010, Japan, Department of Pathology and Laboratory Medicine, Kansai Medical University Hospital, Hirakata, Osaka 573‑1010, Japan

Copyright: © Matsui et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 16
|
Published online on: February 16, 2024

https://doi.org/10.3892/mi.2024.140
Expand metrics +

Abstract

Alveolar adenoma is a rare and benign pulmonary tumor, which originates from type II pneumocytes and is often incidentally identified on radiographic images. Alveolar adenoma presents as a peripleural, solitary and cystic nodule in the lung and may mimic other types of lung tumors, thus rendering its differential diagnosis difficult. Alveolar adenoma is diagnosed based on histopathological and immunohistochemical analyses. The present study describes the case of a 50‑year‑old male patient with alveolar adenoma. He visited a local doctor ~3 years prior due to left chest pain. A chest computed tomography scan revealed a cystic lesion in segment 8 of the left lung. A nodular shadow appeared in the cyst and gradually increased in size; the patient was thus referred to the authors' hospital. The nodule was well‑defined, solitary and solid; thus, lung cancer or aspergilloma were suspected. Thoracoscopic wedge resection was performed as diagnostic therapy. The frozen sections were non‑diagnostic, and a pathological examination revealed an alveolar adenoma with no evidence of malignancy and a negative culture. The patient had a good post‑operative course, with no sign of recurrence at the follow‑up evaluation 46 months later. On the whole, alveolar adenoma is a rare, benign pulmonary tumor that is difficult to diagnose pre‑operatively.

View Figures

View References

1	Yousem SA and Hochholzer L: Alveolar adenoma. Hum Pathol. 17:1066–1071. 1986.PubMed/NCBI View Article : Google Scholar
2	Klaveren RJ, Oudkerk M, Prokop M, Scholten ET, Nackaerts K, Vernhout R, Iersel CA, Bergh KAM, Westeinde SV, Aalst C, et al: Management of lung nodules detected by volume CT scanning. N Engl J Med. 361:2221–2229. 2009.PubMed/NCBI View Article : Google Scholar
3	MacMahon H, Naidich DP, Goo JM, Lee KS, Leung ANC, Mayo JR, Mehta AC, Ohno Y, Powell CA, Prokop M, et al: Guidelines for management of incidental pulmonary nodules detected on CT Images: From the fleischner society 2017. Radiology. 284:228–243. 2017.PubMed/NCBI View Article : Google Scholar
4	Travis WD, Brambilla E, Burke AP, Marx A and Nicholson AG: Introduction to the 2015 World Health Organization classification of tumors of the lung, pleura, thymus, and heart. J Thorac Oncol. 10:1240–1242. 2015.PubMed/NCBI View Article : Google Scholar
5	Bhavsar T, Uppal G, Travaline JM, Gaughan C, Huang Y and Khurana JS: An unusual case of a microscopic alveolar adenoma coexisting with lung carcinoma: A case report and review of the literature. J Med Case Rep. 5(187)2011.PubMed/NCBI View Article : Google Scholar
6	Sak SD, Koseoglu RD, Demirag F, Akbulut H and Gungor A: Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature. APMIS. 115:1443–1449. 2007.PubMed/NCBI View Article : Google Scholar
7	Hsieh MS, Tseng YH, Hua SF and Chou YH: Cystic alveolar adenoma: An unusual clinical presentation of a rare lung neoplasm. Pathology. 47:78–80. 2015.PubMed/NCBI View Article : Google Scholar
8	Burke LM, Rush WI, Khoor A, Mackay B, Oliveira P, Whitsett JA, Singh G, Turnicky R, Fleming MV, Koss MN and Travis WD: Alveolar adenoma: A histochemical, immunohistochemical, and ultrastructural analysis of 17 cases. Hum Pathol. 30:158–1567. 1999.PubMed/NCBI View Article : Google Scholar
9	Wang L, Wang X, Rustam A and Hu J: Alveolar adenoma resected by thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 19:489–491. 2013.PubMed/NCBI View Article : Google Scholar
10	Kondo N, Torii I, Hashimoto M, Takuwa T, Tanaka F, Tsujimura T and Hasegawa S: Alveolar adenoma of the lung: A case report. Ann Thorac Cardiovasc Surg. 17:71–73. 2011.PubMed/NCBI View Article : Google Scholar
11	Saji H, Okada M, Tsuboi M, Nakajima R, Suzuki K, Aokage K, Aoki T, Okami J, Yoshino I, Ito H, et al: Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): A multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial. Lancet. 399:1607–1617. 2022.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Alveolar adenoma with a single cyst: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles