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May-June 2024 Volume 4 Issue 3

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Case Report Open Access

Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report

  • Authors:
    • Shuhei Arima
    • Tatsuo Kanda
    • Mai Totsuka
    • Masayuki Honda
    • Shini Kanezawa
    • Reina Sasaki‑Tanaka
    • Naoki Matsumoto
    • Ryota Masuzaki
    • Hiroaki Yamagami
    • Masahiro Ogawa
    • Hirofumi Kogure
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo 137‑8610, Japan
    Copyright: © Arima et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 23
    |
    Published online on: March 20, 2024
       https://doi.org/10.3892/mi.2024.147
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Abstract

Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis, particularly in patients with advanced‑stage disease, elderly individuals and/or in those with poor liver function. Immune checkpoint inhibitor‑containing therapies, such as atezolizumab, an anti‑programmed death ligand‑1 monoclonal antibody, plus bevacizumab, an anti‑vascular endothelial growth factor monoclonal antibody, may be effective and safe therapeutic options for elderly patients with advanced‑stage HCC. The present study reports the case of a male patient his 80s who consumed alcohol with unresectable advanced‑stage HCC who received combination therapy comprising atezolizumab plus bevacizumab for 6 months. The patient achieved a complete response despite the discontinuation of treatment due to nephrotoxicity. It is critical for patients with HCC and a Child‑Pugh A grade to continue therapy for HCC, even if they are older. The development of more effective therapies is required for patients with advanced‑stage HCC with a worse liver function than those with a Child‑Pugh A grade. The case described in the present study demonstrates the need for obtaining further evidence regarding the efficacy and safety of the combination therapy including atezolizumab plus bevacizumab for elderly patients with advanced‑stage HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Arima S, Kanda T, Totsuka M, Honda M, Kanezawa S, Sasaki‑Tanaka R, Matsumoto N, Masuzaki R, Yamagami H, Ogawa M, Ogawa M, et al: Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report. Med Int 4: 23, 2024.
APA
Arima, S., Kanda, T., Totsuka, M., Honda, M., Kanezawa, S., Sasaki‑Tanaka, R. ... Kogure, H. (2024). Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report. Medicine International, 4, 23. https://doi.org/10.3892/mi.2024.147
MLA
Arima, S., Kanda, T., Totsuka, M., Honda, M., Kanezawa, S., Sasaki‑Tanaka, R., Matsumoto, N., Masuzaki, R., Yamagami, H., Ogawa, M., Kogure, H."Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report". Medicine International 4.3 (2024): 23.
Chicago
Arima, S., Kanda, T., Totsuka, M., Honda, M., Kanezawa, S., Sasaki‑Tanaka, R., Matsumoto, N., Masuzaki, R., Yamagami, H., Ogawa, M., Kogure, H."Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report". Medicine International 4, no. 3 (2024): 23. https://doi.org/10.3892/mi.2024.147
Copy and paste a formatted citation
x
Spandidos Publications style
Arima S, Kanda T, Totsuka M, Honda M, Kanezawa S, Sasaki‑Tanaka R, Matsumoto N, Masuzaki R, Yamagami H, Ogawa M, Ogawa M, et al: Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report. Med Int 4: 23, 2024.
APA
Arima, S., Kanda, T., Totsuka, M., Honda, M., Kanezawa, S., Sasaki‑Tanaka, R. ... Kogure, H. (2024). Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report. Medicine International, 4, 23. https://doi.org/10.3892/mi.2024.147
MLA
Arima, S., Kanda, T., Totsuka, M., Honda, M., Kanezawa, S., Sasaki‑Tanaka, R., Matsumoto, N., Masuzaki, R., Yamagami, H., Ogawa, M., Kogure, H."Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report". Medicine International 4.3 (2024): 23.
Chicago
Arima, S., Kanda, T., Totsuka, M., Honda, M., Kanezawa, S., Sasaki‑Tanaka, R., Matsumoto, N., Masuzaki, R., Yamagami, H., Ogawa, M., Kogure, H."Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report". Medicine International 4, no. 3 (2024): 23. https://doi.org/10.3892/mi.2024.147
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