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Print ISSN: 2754-3242 Online ISSN: 2754-1304
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July-August 2024 Volume 4 Issue 4

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Case Report Open Access

Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report

  • Authors:
    • Masahiro Manabe
    • Yuki Nagano
    • Takahiro Okuno
    • Takeshi Inoue
    • Ki-Ryang Koh
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Osaka General Hospital of West Japan Railway Company, Osaka 545‑0053, Japan, Department of Urology, Minamiosaka Hospital, Osaka 559‑0012, Japan, Department of Pathology, Minamiosaka Hospital, Osaka 559‑0012, Japan, Department of Pathology, Osaka City General Hospital, Osaka 534‑0021, Japan
    Copyright: © Manabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 44
    |
    Published online on: June 12, 2024
       https://doi.org/10.3892/mi.2024.168
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Abstract

Methotrexate (MTX)‑related lymphoproliferative disease (LPD) is one of the most prominent late complications associated with MTX treatment. Although MTX‑related LPD exhibits a relatively high incidence of extranodal disease, the incidence of disease in a urinary bladder is very low. The present study reports the case of a patient with MTX‑related LPD involving a urinary bladder mass. A 75‑year‑old female patient, who had been receiving MTX for ~15 years, was referred to the hospital due to fever and hematuria. A computed tomography scan revealed the thickening of the urinary bladder wall, hydronephrosis and lymph node swelling. The histopathological findings of the urinary bladder mass resulted in a diagnosis of MTX‑related LPD. Although MTX withdrawal did not have any effect, the subsequent chemotherapy resulted in complete remission. Although MTX‑related LPD in the bladder is rare, it is pertinent to consider MTX‑related LPD when hematuria is observed during MTX therapy.
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1 

Kameda H, Fujii T, Nakajima A, Koike R, Sagawa A, Kanbe K, Tomita T, Harigai M and Suzuki Y: Japan College of Rheumatology subcommittee on the guideline for the use of methotrexate in patients with rheumatoid arthritis. Japan College of Rheumatology guideline for the use of methotrexate in patients with rheumatoid arthritis. Mod Rheumatol. 29:31–40. 2019.PubMed/NCBI View Article : Google Scholar

2 

Gaulard P, Swerdlow SH, Harris NL, Sundström C and Jaffe ES: Other iatrogenic immunodeficiency-associated lymphoproliferative disorders. In: WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th edition. Swerdlow SH, Campo E, Harris NL, et al (eds.): IARC press, Lyon, pp462-464, 2017.

3 

Ichikawa A, Arakawa F, Kiyasu J, Sato K, Miyoshi H, Niino D, Kimura Y, Takeuchi M, Yoshida M, Ishibashi Y, et al: Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: Histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression. Eur J Haematol. 91:20–28. 2013.PubMed/NCBI View Article : Google Scholar

4 

Antunes AA, Nesrallah LJ and Srougi M: Non-Hodgkin lymphoma of the bladder. Int Braz J Urol. 30:499–501. 2004.PubMed/NCBI View Article : Google Scholar

5 

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, et al: The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 36:1720–1748. 2022.PubMed/NCBI View Article : Google Scholar

6 

Peyrade F, Jardin F, Thieblemont C, Thyss A, Emile JF, Castaigne S, Coiffier B, Haioun C, Bologna S, Fitoussi O, et al: Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: A multicentre, single-arm, phase 2 trial. Lancet Oncol. 12:460–468. 2011.PubMed/NCBI View Article : Google Scholar

7 

Tokuhira M, Saito S, Suzuki K, Higashi M, Momose S, Shimizu T, Mori T, Kimura Y, Amano K, Okamoto S, et al: Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders. Leuk Lymphoma. 60:2508–2515. 2019.PubMed/NCBI View Article : Google Scholar

8 

Kurita D, Miyoshi H, Ichikawa A, Kato K, Imaizumi Y, Seki R, Sato K, Sasaki Y, Kawamoto K, Shimono J, et al: Methotrexate-associated Lymphoproliferative disorders in patients with rheumatoid arthritis: Clinicopathologic features and prognostic factors. Am J Surg Pathol. 43:869–884. 2019.PubMed/NCBI View Article : Google Scholar

9 

Yamakawa N, Fujimoto M, Kawabata D, Terao C, Nishikori M, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, et al: A clinical, pathological, and genetic characterization of methotrexate-associated lymphoproliferative disorders. J Rheumatol. 41:293–299. 2014.PubMed/NCBI View Article : Google Scholar

10 

Ohsawa M, Aozasa K, Horiuchi K and Kanamaru A: Malignant lymphoma of bladder. Report of three cases and review of the literature. Cancer. 72:1969–1974. 1993.PubMed/NCBI View Article : Google Scholar

11 

Simpson RH, Bridger JE, Anthony PP, James KA and Jury I: Malignant lymphoma of the lower urinary tract. A clinicopathological study with review of the literature. Br J Urol. 65:254–260. 1990.PubMed/NCBI View Article : Google Scholar

12 

Bates AW, Norton AJ and Baithun SI: Malignant lymphoma of the urinary bladder: A clinicopathological study of 11 cases. J Clin Pathol. 53:458–461. 2000.PubMed/NCBI View Article : Google Scholar

13 

Ogihara K, Kosaka T, Kikuchi E, Hongo H, Mikami S and Oya M: Spontaneous regression of Epstein-Barr virus-positive primary diffuse large cell B-cell lymphoma of the urinary bladder after the cessation of enzalutamide. Clin Genitourin Cancer. 14:e215–e218. 2016.PubMed/NCBI View Article : Google Scholar

14 

Simpson WG, Lopez A, Babbar P and Payne LF: Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases. Urol Ann. 7:268–72. 2015.PubMed/NCBI View Article : Google Scholar

15 

Tokuhira M, Saito S, Okuyama A, Suzuki K, Higashi M, Momose S, Shimizu T, Mori T, Anan-Nemoto T, Amano K, et al: Clinicopathologic investigation of methotrexate-induced lymphoproliferative disorders, with a focus on regression. Leuk Lymphoma. 59:1143–1152. 2018.PubMed/NCBI View Article : Google Scholar

16 

Inui Y, Matsuoka H, Yakushijin K, Okamura A, Shimada T, Yano S, Takeuchi M, Ito M, Murayama T, Yamamoto K, et al: Methotrexate-associated lymphoproliferative disorders: Management by watchful waiting and observation of early lymphocyte recovery after methotrexate withdrawal. Leuk Lymphoma. 56:3045–3051. 2015.PubMed/NCBI View Article : Google Scholar

17 

Tokuhira M, Tamaru JI and Kizaki M: Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders. J Clin Exp Hematop. 59:72–92. 2019.PubMed/NCBI View Article : Google Scholar

18 

Al-Sarayfi D, Brink M, Chamuleau MED, Brouwer R, van Rijn RS, Issa D, Deenik W, Huls G, Mous R, Vermaat JSP, et al: R-miniCHOP versus R-CHOP in elderly patients with diffuse large B-cell lymphoma: A propensity matched population-based study. Am J Hematol. 99:216–222. 2024.PubMed/NCBI View Article : Google Scholar

19 

Lontos K, Tsagianni A, Msaouel P, Appleman LJ and Nasioudis D: Primary urinary tract lymphoma: Rare but aggressive. Anticancer Res. 37:6989–6995. 2017.PubMed/NCBI View Article : Google Scholar

20 

Tilly H, Morschhauser F, Sehn LH, Friedberg JW, Trněný M, Sharman JP, Herbaux C, Burke JM, Matasar M, Rai S, et al: Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma. N Engl J Med. 386:351–363. 2022.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Manabe M, Nagano Y, Okuno T, Inoue T and Koh K: Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report. Med Int 4: 44, 2024.
APA
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., & Koh, K. (2024). Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report. Medicine International, 4, 44. https://doi.org/10.3892/mi.2024.168
MLA
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., Koh, K."Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report". Medicine International 4.4 (2024): 44.
Chicago
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., Koh, K."Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report". Medicine International 4, no. 4 (2024): 44. https://doi.org/10.3892/mi.2024.168
Copy and paste a formatted citation
x
Spandidos Publications style
Manabe M, Nagano Y, Okuno T, Inoue T and Koh K: Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report. Med Int 4: 44, 2024.
APA
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., & Koh, K. (2024). Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report. Medicine International, 4, 44. https://doi.org/10.3892/mi.2024.168
MLA
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., Koh, K."Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report". Medicine International 4.4 (2024): 44.
Chicago
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., Koh, K."Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report". Medicine International 4, no. 4 (2024): 44. https://doi.org/10.3892/mi.2024.168
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